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- Pharmacology For Etophylline + Theophylline
Etophylline + Theophylline Pharmacology
Etophylline + Theophylline
About Etophylline + TheophyllineN/AMechanism of Action of Etophylline + TheophyllineN/APharmacokinets of Etophylline + TheophyllineN/AOnset of Action for Etophylline + TheophyllineN/ADuration of Action for Etophylline + TheophyllineN/AHalf Life of Etophylline + TheophyllineN/ASide Effects of Etophylline + TheophyllineN/AContra-indications of Etophylline + TheophyllineN/ASpecial Precautions while taking Etophylline + TheophyllineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Etophylline + TheophyllineN/AInteractions for Etophylline + TheophyllineN/ATypical Dosage for Etophylline + TheophyllineN/ASchedule of Etophylline + TheophyllineN/AStorage Requirements for Etophylline + TheophyllineN/AEffects of Missed Dosage of Etophylline + TheophyllineN/AEffects of Overdose of Etophylline + TheophyllineN/AEtophylline
About EtophyllinePurine (Xanthine )derivative:Theophylline analogs & derivatives, Bronchodilator Agents ,Antiasthmatic.Mechanism of Action of EtophyllineEtophylline is the ethyl salt of Theophylline.It inhibit phosphodiesterase enzyme which degrades cyclic nucleotides intracellularly and it results the cyclic AMP accumulation in the cell. This cause bronchodialatation, cardiac stimulation and vasodilatation. This drug release calcium from sarcoplasmic reticulam, especially in cardiac muscles and results increased cardiac muscle contraction. This drug also blocks adenosine receptors (adenosine acts as a local mediator in CNS & CVS and other organs- which contracts smooth muscles, especially in bronchi, blood vessels etc). This results bronchodialatation and vasodialatation.Pharmacokinets of EtophyllineAbsorption- Well absorbed after oral administration. Rapidly and well absorbed after intravenous administration
Distribution- Widely distributed in the body. 40% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites by demethylation and oxidation. 1-methyluric acid is its metabolite
Excretion- Excreted through urine
Onset of Action for Etophylline15 to 60 min. after oral administration and 15 minutes after intravenous administrationDuration of Action for EtophyllineN/AHalf Life of EtophyllineIts plasma half life is 8 hrsSide Effects of Etophylline1. Upset stomach
2. Stomach pain
3. Diarrhea
4. Headache
5. Restlessness
6. Insomnia
7. Irritability
8. Vomiting
9. Increased or rapid heart rate
10. Irregular heartbeat
11. Seizures
12. Skin rash
Contra-indications of Etophylline1. Hypersensitivity to the drug
2. Peptic ulcer
3. Underlying seizure disorders
Special Precautions while taking Etophylline1.Heart disease
2.Liver disease
3.Peptic ulcer
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Etophylline1. Asthma
2. Chronic obstructive pulmonary disease
3. Chronic bronchitis
4. Emphysema
5. It can be used in premature infants who stop breathing
Interactions for EtophyllineN/ATypical Dosage for EtophyllineUp to 1.5 g / daySchedule of EtophyllineN/AStorage Requirements for EtophyllineN/AEffects of Missed Dosage of EtophyllineN/AEffects of Overdose of EtophyllineN/ATheophylline
About TheophyllineBronchodilator, a methylxanthine derivative, Anti asthma, in COPD.Mechanism of Action of TheophyllineIt inhibit phosphodiesterase enzyme which degrades cyclic nucleotides intracellularly and it results the cyclic AMP accumulation in the cell. This cause bronchodialatation, cardiac stimulation and vasodilatation. This drug release calcium from sarcoplasmic reticulam, especially in cardiac muscles and results increased cardiac muscle contraction. This drug also blocks adenosine receptors (adenosine acts as a local mediator in CNS & CVS and other organs- which contracts smooth muscles, especially in bronchi, blood vessels etc). This results bronchodialatation and vasodialatation.Pharmacokinets of TheophyllineAbsorption- Well absorbed after oral administration. Rapidly and well absorbed after intravenous administration.
Distribution- Widely distributed in the body. 40% bound to the plasma proteins.
Metabolism- Metabolized in the liver by demethylation and oxidation. 1-methyluric acid is its metabolite.
Excretion- Excreted through urine.
Onset of Action for Theophylline15 to 60 min. after oral administration and 15 minutes after intravenous administration.Duration of Action for TheophyllineN/AHalf Life of TheophyllineIts plasma half life is 8 hrsSide Effects of Theophylline1. Upset stomach
2. Stomach pain
3. Diarrhea
4. Headache
5. Restlessness
6. Insomnia
7. Irritability
8. Vomiting
9. Increased or rapid heart rate
10. Irregular heartbeat
11. Seizures
12. Skin rash
Contra-indications of Theophylline1. Hypersensitivity to the drug
2. Peptic ulcer
3. Underlying seizure disorders
Special Precautions while taking Theophylline1. Cardiac disease
2. Hypertension
3. Hyperthyroidism
4. Hepatic impairment
5. Fever
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Theophylline1. Asthma
2. Chronic obstructive pulmonary disease
3. Chronic bronchitis
4. Emphysema
5. It can be used in premature infants who stop breathing
Interactions for TheophyllineBenzodiazepines: Sedative effects may be antagonized.
Beta agonists: Additive effect.
Halothane: Catecholamine induced arrhythmias may occur.
Tetracyclines: Theophylline adverse reaction may be enhanced.
Food: Theophylline elimination is increased by a low carbohydrate, high protein diet.
Typical Dosage for TheophyllineAdults:
Long term management of chronic bronchospasm: 300 to 1000 mg daily in divided doses in every 6 to 8 hrs or 175 to 500 mg every 12 hrs for modified release preparations.
Bronchospasm-
Adults-
5mg/kg body weight every 6 to 8 hrs.
Children- 5 mg/kg every 4 to 6 hrs.
Neonatal apnoea of prematurity-
Child-
More than 24days - 5mg/kg as maintenance dose and 1.5mg/kg every 12 hrs as loading dose.
Less than 24 days- 1mg/kg every 12 hrs.
Intravenous- Management of severe bronchospasm-
Adult- 4 to 5 mg/kg as loading dose over 20 to 30 minutes.
0.4 mg/kg/hr as maintenance dose.
Children- 4 to 5 mg/kg as loading dose over 20 to 30 minutes.
0.8mg/kg/hr as maintenance dose.
Schedule of TheophyllineN/AStorage Requirements for TheophyllineStore it at room temperature and away from excess heat and moisture.Effects of Missed Dosage of TheophyllineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TheophyllineGive symptomatic and supportive treatment. Induce emesis except in convulsive patient. Administer activated charcoal or cathartics to prevent further absorption of the drug.Home Delivery for Etophylline + Theophylline in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including etophylline + theophylline.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for etophylline + theophylline and other medicines and health products. Home delivery services for etophylline + theophylline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take etophylline + theophylline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for etophylline + theophylline before they complete the sale. You can get this information while placing the order for etophylline + theophylline with the pharmacy.
Etophylline + Theophylline is a generic medicine name and there are several brands available for it. Some of the brands for etophylline + theophylline might be better known than etophylline + theophylline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have etophylline + theophylline in stock, you can ask for one of the branded alternatives for etophylline + theophylline.
