Etophylline Pharmacology

Etophylline

About Etophylline
Purine (Xanthine )derivative:Theophylline analogs & derivatives, Bronchodilator Agents ,Antiasthmatic.
Mechanism of Action of Etophylline
Etophylline is the ethyl salt of Theophylline.It inhibit phosphodiesterase enzyme which degrades cyclic nucleotides intracellularly and it results the cyclic AMP accumulation in the cell. This cause bronchodialatation, cardiac stimulation and vasodilatation. This drug release calcium from sarcoplasmic reticulam, especially in cardiac muscles and results increased cardiac muscle contraction. This drug also blocks adenosine receptors (adenosine acts as a local mediator in CNS & CVS and other organs- which contracts smooth muscles, especially in bronchi, blood vessels etc). This results bronchodialatation and vasodialatation.
Pharmacokinets of Etophylline
Absorption- Well absorbed after oral administration. Rapidly and well absorbed after intravenous administration
Distribution- Widely distributed in the body. 40% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites by demethylation and oxidation. 1-methyluric acid is its metabolite
Excretion- Excreted through urine
Onset of Action for Etophylline
15 to 60 min. after oral administration and 15 minutes after intravenous administration
Duration of Action for Etophylline
N/A
Half Life of Etophylline
Its plasma half life is 8 hrs
Side Effects of Etophylline
1. Upset stomach
2. Stomach pain
3. Diarrhea
4. Headache
5. Restlessness
6. Insomnia
7. Irritability
8. Vomiting
9. Increased or rapid heart rate
10. Irregular heartbeat
11. Seizures
12. Skin rash
Contra-indications of Etophylline
1. Hypersensitivity to the drug
2. Peptic ulcer
3. Underlying seizure disorders
Special Precautions while taking Etophylline
1.Heart disease
2.Liver disease
3.Peptic ulcer
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Etophylline
1. Asthma
2. Chronic obstructive pulmonary disease
3. Chronic bronchitis
4. Emphysema
5. It can be used in premature infants who stop breathing
Interactions for Etophylline
N/A
Typical Dosage for Etophylline
Up to 1.5 g / day
Schedule of Etophylline
N/A
Storage Requirements for Etophylline
N/A
Effects of Missed Dosage of Etophylline
N/A
Effects of Overdose of Etophylline
N/A

Home Delivery for Etophylline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including etophylline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for etophylline and other medicines and health products. Home delivery services for etophylline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take etophylline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for etophylline before they complete the sale. You can get this information while placing the order for etophylline with the pharmacy.

Etophylline is a generic medicine name and there are several brands available for it. Some of the brands for etophylline might be better known than etophylline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have etophylline in stock, you can ask for one of the branded alternatives for etophylline.