Ketotifen Pharmacology


About Ketotifen
Second Generation H1 Antagonist, Mast Cell Stabilizer, Antihistamine.
Mechanism of Action of Ketotifen
It is a mast cell stabilizer. This inhibit the development of airway hyper reactivity (associated with activation of platelets by PAF (Platelet Activating Factor) or caused by neural activation following the use of sympathomimetic drugs or the exposure to allergen) by suppressing the priming of eosinophils by human recombinant cytokines and thereby suppression of the influx of eosinophils into inflammatory site. In addition, Ketotifen is a potent antiallergic substance possessing a powerful and sustained noncompetitive histamine (H 1) blocking property. As a result the level of the cell cAMP is enhanced and eosinophilic infiltration is inhibited.
Pharmacokinets of Ketotifen
Absorption-Rapidly absorbed after oral administration.
Distribution-75% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites. Drug also undergo pre systemic metabolism. Ketotifen- N-glucoronide is its inactive metabolite.
Excretion- Excreted through urine (1% as unchanged form).

Onset of Action for Ketotifen
4-6 weeks
Duration of Action for Ketotifen
Half Life of Ketotifen
Its plasma half life is 21 hrs
Side Effects of Ketotifen
1. Drowsiness
2. Dry mouth
3. Dizziness
4. CNS stimulation
5. Weight gain
Contra-indications of Ketotifen
1. Hypersensitivity to the drug
2. Glaucoma
Special Precautions while taking Ketotifen
1. Previous antiasthmatic treatment(minimum of 2 weeks)
2. Any work which require mental alertness such as driving or machine operating
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Ketotifen
1. Rhinitis
2. Conjunctivitis
3. Prophylaxis for bronchial asthma
Interactions for Ketotifen
Sedatives, Hypnotics & Alcohol: May potentiate the effects of these agents, leading to CNS depression.
Oral antidiabetics: Avoid as fall in thrombocyte count reported.

Typical Dosage for Ketotifen
1-2 mg once daily with food.
Children (>2yrs)-
1mg once daily with food
Schedule of Ketotifen
Storage Requirements for Ketotifen
Store in a cool dry place, away from direct heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Ketotifen
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ketotifen
Give symptomatic and supportive treatment.

Home Delivery for Ketotifen in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ketotifen.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ketotifen and other medicines and health products. Home delivery services for ketotifen may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ketotifen only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ketotifen before they complete the sale. You can get this information while placing the order for ketotifen with the pharmacy.

Ketotifen is a generic medicine name and there are several brands available for it. Some of the brands for ketotifen might be better known than ketotifen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ketotifen in stock, you can ask for one of the branded alternatives for ketotifen.