Salbutamol (Inhalers) Pharmacology

Salbutamol (Inhalers)

About Salbutamol (Inhalers)
A short acting Beta2-Adrenergic Agonist, Phenethylamine derivative, Bronchodilator(Antiasthma).
Mechanism of Action of Salbutamol (Inhalers)
Salbutamol is a short acting ?2 receptor agonist. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+-sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles.
?2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibits Phospholipase A2 which produces inhibition of prostaglandins production. Thus Salbutamol can inhibit the broncho-constriction produced by inflammatory mediators.

Pharmacokinets of Salbutamol (Inhalers)
Absorption: It is gradually absorbed after oral inhalation.
Metabolism: It is metabolised to inactive metabolites in the liver.
Excretion: Salbutamol is excreted primarily in the urine (75%) and small amount in the faeces.
Onset of Action for Salbutamol (Inhalers)
5 - 15 minutes
Duration of Action for Salbutamol (Inhalers)
2 - 6 hours
Half Life of Salbutamol (Inhalers)
N/A
Side Effects of Salbutamol (Inhalers)
1. Headache
2. Paradoxical Bronchospasm
3. Hypokalaemia
4. Tremor
5. Anxiety
6. Restlessness
7. Tachycardia
8. Palpitations

Contra-indications of Salbutamol (Inhalers)
1. Hypersensitivity to Salbutamol and other sympathomimetic amines
Special Precautions while taking Salbutamol (Inhalers)
1. Myocardial insufficiency
2. Arrhythmia
3. Hypertension
4. Hyperthyroidism
5. Epilepsy
6. Diabetes
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 6 years: Contraindicated

NEONATES: contraindicated
Indications for Salbutamol (Inhalers)
1. Obstructive airway diseases
2. Acute Bronchospasm
3. Status asthmaticus
Interactions for Salbutamol (Inhalers)
N/A
Typical Dosage for Salbutamol (Inhalers)
Adult: Salbutamol 90mcg/metered spray
Relief of Bronchospasm in patients with reversible obstructive airway disease: 1 - 2 inhalations every 6 - 8 hours
Prevention of exercise-induced Bronchospasm: 200mcg 15 - 30 minutes before exertion
Chronic therapy:Up to 200mcg four times daily
Solutions for Nebulisation: 2 .5 mg 3 - 4 times daily by using nebulisers
Capsules for inhalation: 200mcg inhaled every 6-8 hours using rotahaler device.

Children: 100mcg, the dose may be increased to 200mcg if required.
Prevention of exercise-induced Bronchospasm: 100mcg before exertion, the dose may be increased to 200mcg if required.
Chronic therapy: Up to 200mcg four times daily

Schedule of Salbutamol (Inhalers)
H
Storage Requirements for Salbutamol (Inhalers)
Store at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Salbutamol (Inhalers)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Salbutamol (Inhalers)
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.

Home Delivery for Salbutamol (Inhalers) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including salbutamol (inhalers).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for salbutamol (inhalers) and other medicines and health products. Home delivery services for salbutamol (inhalers) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take salbutamol (inhalers) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for salbutamol (inhalers) before they complete the sale. You can get this information while placing the order for salbutamol (inhalers) with the pharmacy.

Salbutamol (Inhalers) is a generic medicine name and there are several brands available for it. Some of the brands for salbutamol (inhalers) might be better known than salbutamol (inhalers) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have salbutamol (inhalers) in stock, you can ask for one of the branded alternatives for salbutamol (inhalers).