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- Pharmacology For Ibuprofen + Pseudoephedrine
Ibuprofen + Pseudoephedrine Pharmacology
Ibuprofen + Pseudoephedrine
About Ibuprofen + PseudoephedrineN/AMechanism of Action of Ibuprofen + PseudoephedrineN/APharmacokinets of Ibuprofen + PseudoephedrineN/AOnset of Action for Ibuprofen + PseudoephedrineN/ADuration of Action for Ibuprofen + PseudoephedrineN/AHalf Life of Ibuprofen + PseudoephedrineN/ASide Effects of Ibuprofen + PseudoephedrineN/AContra-indications of Ibuprofen + PseudoephedrineN/ASpecial Precautions while taking Ibuprofen + PseudoephedrineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ibuprofen + PseudoephedrineN/AInteractions for Ibuprofen + PseudoephedrineN/ATypical Dosage for Ibuprofen + PseudoephedrineN/ASchedule of Ibuprofen + PseudoephedrineN/AStorage Requirements for Ibuprofen + PseudoephedrineN/AEffects of Missed Dosage of Ibuprofen + PseudoephedrineN/AEffects of Overdose of Ibuprofen + PseudoephedrineN/AIbuprofen
About IbuprofenNSAID, a propionic acid derivative, Analgesic and anti-inflammatory.Mechanism of Action of IbuprofenIbuprofen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Ibuprofen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits platelet aggregation and prolongs bleeding time.Pharmacokinets of IbuprofenAbsorption: Ibuprofen is rapidly absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Ibuprofen and its metabolites are excreted mainly in the urine and some amount in bile.Onset of Action for Ibuprofen? hoursDuration of Action for Ibuprofen4-6 hours.Half Life of Ibuprofen2 hoursSide Effects of Ibuprofen1.Nausea
2.Vomiting
3.Diarrhoea
4.Gastrointestinal bleeding
5.Abdominal distress
6.Constipation
7.Peptic ulcer
8.Dyspepsia
9.Headache
10.Drowsiness
11.Blurring of vision
12.Tinnitus
13.Depression
14.Thrombocytopenia
15.Rash
16.Pruritis
Contra-indications of Ibuprofen1.Hypersensitivity to Ibuprofen and other NSAIDs
2.Peptic ulcer
Special Precautions while taking Ibuprofen1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Bleeding disorders
7.Phenylketonuria
8.Oedema
9.Heart failure
10.Myocardial infarction
11.Stroke
Pregnancy Related InformationUse with caution
PREGNANCY in third trimester: contraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
CHILDREN below 6 months: contraindicatedIndications for Ibuprofen1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of fever, pain and inflammation in dental, minor surgery and orthopedic
7.Dysmenorrhoea
8.Juvenile arthritis
9.Migraine
10.Patent ductus arteriosus(IV)
Interactions for IbuprofenN/ATypical Dosage for IbuprofenAdult: 1.2 g / day in3 divided doses
Arthritis, gout and dental pain: 300 - 800 mg 3 times daily dose can be increased if needed.
Maximum dose: 3200 mg / day
Pain, Dysmenorrhoea: 1600 - 2400 mg / day in 4 - 6 divided doses
Fever: 600 mg / day in 3 divided doses.
Maximum dose: 1200 mg / day
For migraine: 400 -800 mg 3 times daily
Children: 15- 20 mg / kg body weight / day in 3 - 4 divided doses
Maximum dose: 40 mg / kg body weight / day
Schedule of IbuprofenHStorage Requirements for IbuprofenStore Ibuprofen at 15-30 degree C in a tightly closed light resistant container.Effects of Missed Dosage of IbuprofenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of IbuprofenGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Excretion of the drug can be enhanced by administration of alkaline diuretics.Pseudoephedrine
About PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
Home Delivery for Ibuprofen + Pseudoephedrine in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ibuprofen + pseudoephedrine and other medicines and health products. Home delivery services for ibuprofen + pseudoephedrine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take ibuprofen + pseudoephedrine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ibuprofen + pseudoephedrine before they complete the sale. You can get this information while placing the order for ibuprofen + pseudoephedrine with the pharmacy.
Ibuprofen + Pseudoephedrine is a generic medicine name and there are several brands available for it. Some of the brands for ibuprofen + pseudoephedrine might be better known than ibuprofen + pseudoephedrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ibuprofen + pseudoephedrine in stock, you can ask for one of the branded alternatives for ibuprofen + pseudoephedrine.
