Desloratadine Pharmacology

Desloratadine

About Desloratadine
Second Generation long-acting tricyclic H1 Antagonist, Antihistamine.
Mechanism of Action of Desloratadine
This second generation antihistamine has a selective peripheral H1-antagonist action.Desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This inhibit the action of histamine, which subsequently leads to temporary relief of the negative symptoms brought by histamine
Pharmacokinets of Desloratadine
Absorption- Rapidly absorbed after oral administration
Distribution- Widely distributed in the body. 85% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excrete through urine (40% as conjugated form) and feces

Onset of Action for Desloratadine
N/A
Duration of Action for Desloratadine
N/A
Half Life of Desloratadine
Its plasma half life is 50hrs
Side Effects of Desloratadine
1. Dizziness
2. Dry mouth
3. Dysmenorrhea
4. Dyspepsia
5. Belching
6. Heartburn
7. Indigestion
8. Stomach discomfort
9. Fatigue
10. Myalgia
11. Difficulty in moving
12. Pharyngitis
13. Fever
14. Hoarseness
15. Runny nose
16. Tender swollen glands in neck
17. Trouble in swallowing
18. Voice changes
19. Somnolence
20. Nausea
Contra-indications of Desloratadine
1. Dizziness
2. Dry mouth
3. Dysmenorrhea
4. Dyspepsia
5. Belching
6. Heartburn
7. Iindigestion
8. Stomach discomfort
9. Fatigue
10. Myalgia
11. Difficulty in moving
12. Pharyngitis
13. Fever
14. Hoarseness
15. Runny nose
16. Tender swollen glands in neck
17. Trouble in swallowing
18. Voice changes
19. Somnolence
20. Nausea
Special Precautions while taking Desloratadine
1. Liver disease
2. Kidney disease
3. Phenylketonuria
4. Any work which require mental alertness such as driving and machine operation
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Desloratadine
1. Hay fever
2. Watery eyes
3. Runny nose
4. Itching eyes
5. Sneezing
6. Hives
7. Decongestant
Interactions for Desloratadine
N/A
Typical Dosage for Desloratadine
Oral-
Adult (general dose)-
5mg/day
Children (>12yrs)-Same as adult
Schedule of Desloratadine
N/A
Storage Requirements for Desloratadine
Stored at room temperature. Protect from light and excessive heat. Keep out of reach of children
Effects of Missed Dosage of Desloratadine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Desloratadine
Give symptomatic and supportive treatment

Home Delivery for Desloratadine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including desloratadine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for desloratadine and other medicines and health products. Home delivery services for desloratadine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take desloratadine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for desloratadine before they complete the sale. You can get this information while placing the order for desloratadine with the pharmacy.

Desloratadine is a generic medicine name and there are several brands available for it. Some of the brands for desloratadine might be better known than desloratadine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have desloratadine in stock, you can ask for one of the branded alternatives for desloratadine.