Fexofenadine Pharmacology


About Fexofenadine
Second Generation H1 Antagonist, Antihistamine.
Mechanism of Action of Fexofenadine
Fexofenadine blocks one type of peripheral receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine (Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing.) and the allergic symptoms produced by it.
Pharmacokinets of Fexofenadine
Absorption- Rapidly absorbed after oral administration
Distribution- Widely distributed in the body. 60-70% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excreted through urine (10% as unchanged), bile and feces

Onset of Action for Fexofenadine
Duration of Action for Fexofenadine
14 hrs
Half Life of Fexofenadine
14.4 hrs
Side Effects of Fexofenadine
1. Headache
2. Dizziness
3. Drowsiness
4. Back pain
5. Cough
6. Nausea
Contra-indications of Fexofenadine
Contraindicated in patients with hypersensitivity to the drug or other ingredients
Special Precautions while taking Fexofenadine
1. Renal dysfunction
2. Any work which require mental alertness like driving and machine operations
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Fexofenadine
1. Hay fever
2. Runny nose
3. Sneezing
4. Tearing eyes
5. Hives
Interactions for Fexofenadine
An increase in the level of fexofenadine in plasma of 2-times was observed after co-administration of erythromycin or ketoconazole.
Typical Dosage for Fexofenadine
Adult and children (12yrs)-
Allergic rhinitis:120mg once daily
Allergic skin conditions:180mg once daily

Schedule of Fexofenadine
Storage Requirements for Fexofenadine
Store at room temperature and away from excess heat and moisture
Effects of Missed Dosage of Fexofenadine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Fexofenadine
Give symptomatic and supportive treatment

Home Delivery for Fexofenadine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fexofenadine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fexofenadine and other medicines and health products. Home delivery services for fexofenadine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fexofenadine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fexofenadine before they complete the sale. You can get this information while placing the order for fexofenadine with the pharmacy.

Fexofenadine is a generic medicine name and there are several brands available for it. Some of the brands for fexofenadine might be better known than fexofenadine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fexofenadine in stock, you can ask for one of the branded alternatives for fexofenadine.