Ebastine Pharmacology

Ebastine

About Ebastine
Second generation, long-acting and selective H1 antagonist, Non-sedative Antihistamine.
Mechanism of Action of Ebastine
Drug and its active metabolite is selective peripheral histamine H1 receptor antagonist. Thus it prevents the attachment of histamine on receptors and its activation (Activation of receptors of histamine on various tissues produce various allergic symptoms e.g. Runny nose).Ebastine also has a specific inhibitory effect on Th2-type cytokine production and inhibit T cell migration and pro-inflammatory cytokine production by T cells and macrophages
Pharmacokinets of Ebastine
Absorption - Rapidly absorbed after oral administration
Distribution- Widely distributed in the body. >95% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites by N-dealkylation and hydroxylation.Carebastine is its active metabolite.
Excretion- Excreted through urine

Onset of Action for Ebastine
N/A
Duration of Action for Ebastine
N/A
Half Life of Ebastine
Its plasma half life is 15-19 hrs
Side Effects of Ebastine
1. Headache
2. Dry mouth
3. Drowsiness
4. Pharyngitis
5. Abdominal pain
6. Dyspepsia
7. Asthenia
8. Epistaxis
9. Rhinitis
10. Sinusitis
11. Nausea
12. Insomnia
Contra-indications of Ebastine
1. Hypersensitivity to Ebastine or any of its ingredients
2. Cardiac arrhythmia
Special Precautions while taking Ebastine
1. Long QT syndrome
2. Hypokalemia
3. Hepatic impairment
4. Renal impairment


Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Ebastine
1. Seasonal and perennial allergic rhinitis
2. Idiopathic chronic urticaria
3. T cell-mediated allergic inflammatory disorders (asthma, atopic dermatitis)
4. Th2 -type autoimmune diseases

Interactions for Ebastine
Ketoconazole / Erythromycin: When ebastine is given concomitantly a pharmacokinetic and pharmacodynamic interaction has been observed; an 18-19 msec (4.7%-5%) increase in QT has been reported with either combination.
Typical Dosage for Ebastine
Oral-
Adult-10 mg once a day


Schedule of Ebastine
N/A
Storage Requirements for Ebastine
Store below 25?C.Protect from light. Keep out of reach of children
Effects of Missed Dosage of Ebastine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Ebastine
Give symptomatic and supportive treatment

Home Delivery for Ebastine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ebastine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ebastine and other medicines and health products. Home delivery services for ebastine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ebastine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ebastine before they complete the sale. You can get this information while placing the order for ebastine with the pharmacy.

Ebastine is a generic medicine name and there are several brands available for it. Some of the brands for ebastine might be better known than ebastine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ebastine in stock, you can ask for one of the branded alternatives for ebastine.