Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals Pharmacology

Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

About Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Mechanism of Action of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Pharmacokinets of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Onset of Action for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

N/A

Duration of Action for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

N/A

Half Life of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Side Effects of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Contra-indications of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Special Precautions while taking Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Interactions for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Typical Dosage for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Schedule of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Storage Requirements for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Effects of Missed Dosage of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Effects of Overdose of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals

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Glucosamine

About Glucosamine

Amino sugar,Monosaccharide derivative, Anti-inflammatory,Antiarthritic.

Mechanism of Action of Glucosamine

It stimulates cartilage cells to produce glucosaminoglycans and proteoglycans which are the building blocks of cartilage. This stops the progression of OA (osteoarthritis) and possibly reverses the process. It also has anti-inflammatory properties by its inhibition of proteolytic enzymes.

Pharmacokinets of Glucosamine

Absorption- Well absorbed after oral administration
Distribution- Widely distributed into joint tissues
Excretion - Excreted through urine

Onset of Action for Glucosamine

N/A

Duration of Action for Glucosamine

N/A

Half Life of Glucosamine

N/A

Side Effects of Glucosamine

1. Epigastric pain
2. Tenderness
3. Heartburn
4. Diarrhoea
5. Nausea
6. Drowsiness
7. Headache
8. Insomnia
9. Vomiting
10. Constipation
11. Anorexia
12. Erythema
13. Pruritis

Contra-indications of Glucosamine

Contraindicated in patients with hypersensitivity to the drug

Special Precautions while taking Glucosamine

1.Blood sugars carefully monitored because Glucosamine may increase insulin resistance
2.In normal and diabetic patients

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated

Indications for Glucosamine

1. Osteo arthritis.
2. Rheumatoid arthritis

Interactions for Glucosamine

N/A

Typical Dosage for Glucosamine

Oral-
Adult:1200mg /day

Schedule of Glucosamine

N/A

Storage Requirements for Glucosamine

Store in cool (<30 degree C) and dark place

Effects of Missed Dosage of Glucosamine

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Glucosamine

Give symptomatic and supportive treatment

Chondroitin Sulphate

About Chondroitin Sulphate

A sulfated glycosaminoglycan (mucopolysaccharides, Dietary supplement , anti-rheumatic and anti-inflammatory.

Mechanism of Action of Chondroitin Sulphate

Chondroitin sulfate is part of a large protein molecule (proteoglycan) that gives cartilage elasticity.
It stimulates cartilage cells to produce glucosaminoglycans and proteoglycans which are the building blocks of cartilage. This stops the progression of OA (osteoarthritis) and possibly reverses the process. It also has anti-inflammatory properties by its inhibition of proteolytic enzymes.

Pharmacokinets of Chondroitin Sulphate

Absorption- Well absorbed after oral administration
Distribution- Widely distributed into joint tissues
Excretion - Excreted through urine

Onset of Action for Chondroitin Sulphate

N/A

Duration of Action for Chondroitin Sulphate

N/A

Half Life of Chondroitin Sulphate

N/A

Side Effects of Chondroitin Sulphate

1. Epigastric pain
2. Tenderness
3. Heartburn
4. Diarrhoea
5. Nausea
6. Drowsiness
7. Headache
8. Insomnia
9. Vomiting
10. Constipation
11. Anorexia
12. Erythema
13. Pruritis

Contra-indications of Chondroitin Sulphate

Contraindicated in patients with hypersensitivity to the drug

Special Precautions while taking Chondroitin Sulphate

1.Blood sugars carefully monitored because Glucosamine may increase insulin resistance
2.In normal and diabetic patients

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated

Indications for Chondroitin Sulphate

N/A

Interactions for Chondroitin Sulphate

N/A

Typical Dosage for Chondroitin Sulphate

N/A

Schedule of Chondroitin Sulphate

N/A

Storage Requirements for Chondroitin Sulphate

Store in cool (<30 degree C) and dark place

Effects of Missed Dosage of Chondroitin Sulphate

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Chondroitin Sulphate

Give supportive measures and symptomatic treatment.

Vitamin C

About Vitamin C

Water soluble vitamin, antioxidant.

Mechanism of Action of Vitamin C

Vitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.

Pharmacokinets of Vitamin C

Absorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.

Onset of Action for Vitamin C

N/A

Duration of Action for Vitamin C

N/A

Half Life of Vitamin C

N/A

Side Effects of Vitamin C

1. Discomfort at injection site
2. Acid urine
3. Renal calculi
4. Oxaluria

Contra-indications of Vitamin C

No known contraindications

Special Precautions while taking Vitamin C

1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

May be used

Indications for Vitamin C

1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries

Interactions for Vitamin C

Oral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.

Typical Dosage for Vitamin C

Oral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Scurvy:
Oral:
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.

Schedule of Vitamin C

C1 (Oral)
C (Parenteral)

Storage Requirements for Vitamin C

Store in a cool dry area in a well closed container. Protects from moisture, light and direct heat.

Effects of Missed Dosage of Vitamin C

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vitamin C

Discontinue the therapy and provide symptomatic and supportive measures.

Vitamin D3

About Vitamin D3

N/A

Mechanism of Action of Vitamin D3

Vitamin D3 is a form of vitamin D. It is also called as Cholecalciferol.7-Dehydrocholesterol is the precursor of vitamin D3 and only forms the vitamin after being exposed to UV radiation.After exposure to the sun, cholecalciferol is sent to the liver to be hydroxylated where it becomes 25-Hydroxyvitamin D3.Next, it is sent to the kidney and once again hydroxylated becoming 1,25-Hydroxyvitamin D3. 1,25-Hydroxyvitmain D3 is the active form of vitamin D3, for this reason vitamin D is often referred to as a prohormone.Vitamin D exerts it`s action by influencing calcium homoeostasis. It increases the intestinal absorption of calcium and phosphate. It binds to the cytoplasmic Vitamin D receptor and translocates to the nucleus and thus increases the synthesis of specific m RNA and regulates protein synthesis. It increases the synthesis of a carrier protein for calcium called "calbindin" or calcium binding protein. Activation of Vitamin D receptor enhances endocytotic capture of calcium and it`s transport across duodenal mucosal cells in a vesicular form. Vitamin D promotes resorption of calcium and phosphate from bone by enhancing recruitment and differentiation of osteoclast precursors in the bone remodeling units. It helps in bone mineralization.

Pharmacokinets of Vitamin D3

Absorption: Well absorbed orally in the presence of bile salts, Malabsorption and steatorrhoea interfere with it`s absorption.
Distribution: Widely distributed in a protein bound form. It is stored in adipose tissue and liver.
Metabolism: It is hydroxylated in to both active and inactive metabolites and also metabolized in kidney.
Excretion: Metabolites are excreted mainly through bile.

Onset of Action for Vitamin D3

N/A

Duration of Action for Vitamin D3

N/A

Half Life of Vitamin D3

N/A

Side Effects of Vitamin D3

1. Hypercalcaemia
2. Fatigue
3. Weakness
4. Diarrhoea
5. Vomiting
6. Sluggishness
7. Albuminuria
8. Polyuria
9. Calcification of soft tissues (blood vessels, parenchymal organs including heart)
10. Arrhythmias
11. Renal stones
12. Growh retardation in children
13. Hypertension
14. Anorexia
15. Nausea
16. Constipation
17. Elevated liver enzymes

Contra-indications of Vitamin D3

1. Hypercalcaemia
2. Hypervitaminosis D
3. Renal osteodystrophy with hyperphosphatemia
4. Renal impairment

Special Precautions while taking Vitamin D3

1. Renal diseases
2. Renal stones
3. Cardiac diseases
4. Arteriosclerosis
5. Coronary diseases

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution

Indications for Vitamin D3

1. Rickets and Osteomalacia
2. Hypoparathyroidism
3. Fanconi`s syndrome
4. Osteoporosis

Interactions for Vitamin D3

Antacids: Hypermagnesemia may develop in patients on renal dialysis who take magnesium containing antacids.
Digitalis glycosides: May precipitate cardiac arrhythmias due to hypercalcemia.
Verapamil: Atrial fibrillation may occur.
Cholestyramine: Intestinal absorption of Vitamin D may be reduced.
Mineral Oil: Prolonged use of mineral oil may result in reduced absoprtion of Vitamin D.
Phenytoin, Barbiturates: Half life of vitamin D may be reduced.
Thaizide diuretics: Hypoparathyroid patients on Vitamin D may develop hypercalcemia due to thiazide diuretics.

Typical Dosage for Vitamin D3

Oral:
Adults:
Nutritional Rickets and Osteomalacia: 25 to 125mcg daily in normal gastrointestinal absorption. In severe malabsorption; 250mcg to 7.5mg orally or 250mcg I.M.
Vitamin dependent Rickets: 250mcg to 1.5mg daily
Hypoparathyroidism: 625mcg to 5mg daily with calcium supplements
Fanconi`s syndrome: 1.25 to 5mg daily
Osteoporosis: 25 to 250mcg daily or 1.25mg once weekly with calcium and fluoride supplements.
Hypophosphatemia: 250mcg to 1.5mg along with phosphate supplements
Children:
Nutritional Rickets and Osteomalacia: 25 to 125mcg daily in normal gastrointestinal absorption. In severe malabsorption; 250mcg to 625mcg orally
Vitamin dependent Rickets: 75 to 125mcg daily.
Fanconi`s syndrome: 625mcg to 1.25mg daily
Hypophosphatemia: 1 to 2mg daily with phosphate supplements. Increase the dose in increments of 250 to 500mcg at intervals of 3 to 4months until desired therapeutic response is obtained.

Schedule of Vitamin D3

N/A

Storage Requirements for Vitamin D3

Store in a well closed container in a cool place. Protect from light and excess heat. Keep out of reach of children.

Effects of Missed Dosage of Vitamin D3

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vitamin D3

Provide supportive and symptomatic treatment. Stops the treatment and starting a low calcium diet. Increases the fluid intake and administer Loop diuretics like furosemide may be given with saline I.V. infusion to increase calcium excretion. Calcitonin may decrease hypercalcaemia.

Vitamin E

About Vitamin E

N/A

Mechanism of Action of Vitamin E

Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.

Pharmacokinets of Vitamin E

Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.

Onset of Action for Vitamin E

N/A

Duration of Action for Vitamin E

N/A

Half Life of Vitamin E

N/A

Side Effects of Vitamin E

1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence

Contra-indications of Vitamin E

1. Hypersensitivity to the drug
2. Should not administer intravenously

Special Precautions while taking Vitamin E

1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens

Pregnancy Related Information

May be used

Old Age Related Information

N/A

Breast Feeding Related Information

May be used

Children Related Information

N/A

Indications for Vitamin E

1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant

Interactions for Vitamin E

Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.

Typical Dosage for Vitamin E

Oral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.

Schedule of Vitamin E

Storage Requirements for Vitamin E

Store in a well closed container in a cool dry place. Protect from light.

Effects of Missed Dosage of Vitamin E

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vitamin E

Provide supportive measures and symptomatic treatment.

Methyl sulfonyl methane

About Methyl sulfonyl methane

N/A

Mechanism of Action of Methyl sulfonyl methane

MSM has been proven to have anti-inflammatory and antioxidant mechanisms in an in vitro study6 in which human neutrophils were artificially stimulated to produce oxidative compounds, including hydrogen peroxide, superoxide, and hypochlorous acid. After cell lines were treated with either DMSO or DMSO2, these free radical by-products were decreased.

Pharmacokinets of Methyl sulfonyl methane

N/A

Onset of Action for Methyl sulfonyl methane

N/A

Duration of Action for Methyl sulfonyl methane

N/A

Half Life of Methyl sulfonyl methane

N/A

Side Effects of Methyl sulfonyl methane

1.Nausea
2.Diarrhea
3.Bloating
4.Fatigue
5.Headache
6.Insomnia
7.Itching or worsening of allergy symptoms.

Contra-indications of Methyl sulfonyl methane

N/A

Special Precautions while taking Methyl sulfonyl methane

N/A

Pregnancy Related Information

Not recommended

Old Age Related Information

N/A

Breast Feeding Related Information

Not recommended

Children Related Information

N/A

Indications for Methyl sulfonyl methane

1.To reduce pain and swelling of the joints caused by osteoarthritis.
2.Interstitial cystitis

Interactions for Methyl sulfonyl methane

N/A

Typical Dosage for Methyl sulfonyl methane

Oral: For osteoarthritis: 500 mg three times daily up to 3 grams twice daily.

Schedule of Methyl sulfonyl methane

N/A

Storage Requirements for Methyl sulfonyl methane

N/A

Effects of Missed Dosage of Methyl sulfonyl methane

If a dose is missed, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Effects of Overdose of Methyl sulfonyl methane

If over dosage is suspected,contact immediate medical attention.

Minerals

About Minerals

Dietary mineral supplement, Nutritional supplement.

Mechanism of Action of Minerals

N/A

Pharmacokinets of Minerals

N/A

Onset of Action for Minerals

N/A

Duration of Action for Minerals

N/A

Half Life of Minerals

N/A

Side Effects of Minerals

N/A

Contra-indications of Minerals

N/A

Special Precautions while taking Minerals

N/A

Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Minerals

N/A

Interactions for Minerals

N/A

Typical Dosage for Minerals

N/A

Schedule of Minerals

N/A

Storage Requirements for Minerals

N/A

Effects of Missed Dosage of Minerals

N/A

Effects of Overdose of Minerals

N/A

Home Delivery for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals and other medicines and health products. Home delivery services for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals before they complete the sale. You can get this information while placing the order for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals with the pharmacy.

Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals is a generic medicine name and there are several brands available for it. Some of the brands for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals might be better known than glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals itself. If the pharmacy that's willing to deliver medicines to your home doesn't have glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals in stock, you can ask for one of the branded alternatives for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals.