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- Pharmacology For Vitamin C + Methyl sulfonyl methane
Vitamin C + Methyl sulfonyl methane Pharmacology
Vitamin C + Methyl sulfonyl methaneAbout Vitamin C + Methyl sulfonyl methaneN/AMechanism of Action of Vitamin C + Methyl sulfonyl methaneN/APharmacokinets of Vitamin C + Methyl sulfonyl methaneN/AOnset of Action for Vitamin C + Methyl sulfonyl methaneN/ADuration of Action for Vitamin C + Methyl sulfonyl methaneN/AHalf Life of Vitamin C + Methyl sulfonyl methaneN/ASide Effects of Vitamin C + Methyl sulfonyl methaneN/AContra-indications of Vitamin C + Methyl sulfonyl methaneN/ASpecial Precautions while taking Vitamin C + Methyl sulfonyl methaneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Vitamin C + Methyl sulfonyl methaneN/AInteractions for Vitamin C + Methyl sulfonyl methaneN/ATypical Dosage for Vitamin C + Methyl sulfonyl methaneN/ASchedule of Vitamin C + Methyl sulfonyl methaneN/AStorage Requirements for Vitamin C + Methyl sulfonyl methaneN/AEffects of Missed Dosage of Vitamin C + Methyl sulfonyl methaneN/AEffects of Overdose of Vitamin C + Methyl sulfonyl methaneN/A
Vitamin CAbout Vitamin CWater soluble vitamin, antioxidant.Mechanism of Action of Vitamin CVitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.Pharmacokinets of Vitamin CAbsorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.
Onset of Action for Vitamin CN/ADuration of Action for Vitamin CN/AHalf Life of Vitamin CN/ASide Effects of Vitamin C1. Discomfort at injection site
2. Acid urine
3. Renal calculi
Contra-indications of Vitamin CNo known contraindicationsSpecial Precautions while taking Vitamin C1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Vitamin C1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries
Interactions for Vitamin COral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.Typical Dosage for Vitamin COral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.
Schedule of Vitamin CC1 (Oral)
C (Parenteral)Storage Requirements for Vitamin CStore in a cool dry area in a well closed container. Protects from moisture, light and direct heat.Effects of Missed Dosage of Vitamin CTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin CDiscontinue the therapy and provide symptomatic and supportive measures.
Methyl sulfonyl methaneAbout Methyl sulfonyl methaneN/AMechanism of Action of Methyl sulfonyl methaneMSM has been proven to have anti-inflammatory and antioxidant mechanisms in an in vitro study6 in which human neutrophils were artificially stimulated to produce oxidative compounds, including hydrogen peroxide, superoxide, and hypochlorous acid. After cell lines were treated with either DMSO or DMSO2, these free radical by-products were decreased.Pharmacokinets of Methyl sulfonyl methaneN/AOnset of Action for Methyl sulfonyl methaneN/ADuration of Action for Methyl sulfonyl methaneN/AHalf Life of Methyl sulfonyl methaneN/ASide Effects of Methyl sulfonyl methane1.Nausea
7.Itching or worsening of allergy symptoms.
Contra-indications of Methyl sulfonyl methaneN/ASpecial Precautions while taking Methyl sulfonyl methaneN/APregnancy Related InformationNot recommendedOld Age Related InformationN/ABreast Feeding Related InformationNot recommendedChildren Related InformationN/AIndications for Methyl sulfonyl methane1.To reduce pain and swelling of the joints caused by osteoarthritis.
Interactions for Methyl sulfonyl methaneN/ATypical Dosage for Methyl sulfonyl methaneOral: For osteoarthritis: 500 mg three times daily up to 3 grams twice daily.Schedule of Methyl sulfonyl methaneN/AStorage Requirements for Methyl sulfonyl methaneN/AEffects of Missed Dosage of Methyl sulfonyl methaneIf a dose is missed, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.Effects of Overdose of Methyl sulfonyl methaneIf over dosage is suspected,contact immediate medical attention.
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