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- Pharmacology For Paracetamol + Chlorpheniramine Maleate
Paracetamol + Chlorpheniramine Maleate Pharmacology
Paracetamol + Chlorpheniramine MaleateAbout Paracetamol + Chlorpheniramine MaleateN/AMechanism of Action of Paracetamol + Chlorpheniramine MaleateN/APharmacokinets of Paracetamol + Chlorpheniramine MaleateN/AOnset of Action for Paracetamol + Chlorpheniramine MaleateN/ADuration of Action for Paracetamol + Chlorpheniramine MaleateN/AHalf Life of Paracetamol + Chlorpheniramine MaleateN/ASide Effects of Paracetamol + Chlorpheniramine MaleateN/AContra-indications of Paracetamol + Chlorpheniramine MaleateN/ASpecial Precautions while taking Paracetamol + Chlorpheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Paracetamol + Chlorpheniramine MaleateN/AInteractions for Paracetamol + Chlorpheniramine MaleateN/ATypical Dosage for Paracetamol + Chlorpheniramine MaleateN/ASchedule of Paracetamol + Chlorpheniramine MaleateN/AStorage Requirements for Paracetamol + Chlorpheniramine MaleateN/AEffects of Missed Dosage of Paracetamol + Chlorpheniramine MaleateN/AEffects of Overdose of Paracetamol + Chlorpheniramine MaleateN/A
ParacetamolAbout ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Chlorpheniramine MaleateAbout Chlorpheniramine MaleateN/AMechanism of Action of Chlorpheniramine MaleateN/APharmacokinets of Chlorpheniramine MaleateN/AOnset of Action for Chlorpheniramine MaleateN/ADuration of Action for Chlorpheniramine MaleateN/AHalf Life of Chlorpheniramine MaleateN/ASide Effects of Chlorpheniramine MaleateN/AContra-indications of Chlorpheniramine MaleateFirst Generation alkylamine H1 Antagonist, Antihistamine.Special Precautions while taking Chlorpheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Chlorpheniramine MaleateN/AInteractions for Chlorpheniramine MaleateN/ATypical Dosage for Chlorpheniramine MaleateN/ASchedule of Chlorpheniramine MaleateN/AStorage Requirements for Chlorpheniramine MaleateN/AEffects of Missed Dosage of Chlorpheniramine MaleateN/AEffects of Overdose of Chlorpheniramine MaleateN/A
Home Delivery for Paracetamol + Chlorpheniramine Maleate in Your City
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Paracetamol + Chlorpheniramine Maleate is a generic medicine name and there are several brands available for it. Some of the brands for paracetamol + chlorpheniramine maleate might be better known than paracetamol + chlorpheniramine maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have paracetamol + chlorpheniramine maleate in stock, you can ask for one of the branded alternatives for paracetamol + chlorpheniramine maleate.