Diclofenac Topical Pharmacology

Diclofenac Topical

About Diclofenac Topical
NSAID, Topical anti-inflammatory and analgesic.
Mechanism of Action of Diclofenac Topical
Its anti-inflammatory/antipyretic/analgesic action is due to the inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (((COX))).This also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid
Diclofenac may also inhibit the lipooxygenase pathways (((thus reducing formation of the leukotrienes))) and phospholipase A2.
Pharmacokinets of Diclofenac Topical
Absorption- Well absorbed systemically.
Distribution- Well distributed in the body as plasma protein bound (((99%))) form.
Metabolism -It is metabolized in the liver by conjugation or hydroxylation which leads to phenolic and glucoronide conjugates.
Excretion- It is excreted through the urine
Onset of Action for Diclofenac Topical
Duration of Action for Diclofenac Topical
Half Life of Diclofenac Topical
The plasma half life is 1-2 hours
Side Effects of Diclofenac Topical
1. Shortness of breath
2. Closing of your throat
3. Swelling of your lips, face, or tongue
4. Dry, itching, or burning eyes
5. Eye pain
6. Fever
7. Headaches, including migraines
8. High blood pressure
9. Increased sensitivity of eyes to light
10. Infection
11. Nasal congestion
12. Ulcers or sores on skin
13. Wheezing
14. Exfoliation
Contra-indications of Diclofenac Topical
Hypersensitivity to the drug
Special Precautions while taking Diclofenac Topical
1.Diclofenac topical is for external use only
2.Do not use diclofenac topical on skin that is irritated, peeling, or infected or on open wounds.
3.Avoid exposure to sunlight or artificial UV rays (((e.g. sunlamps))) during treatment with diclofenac topical.
4.Use a sunscreen (((minimum SPF 15))) and wear protective clothing when sun exposure is unavoidable.
5. Stomach or intestinal ulcers or bleeding
6. Kidney disease
7. Liver disease
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Diclofenac Topical
1. Warty overgrowths of skin (((actinic keratoses))) on sun-exposed areas of the body
2. Sprains
3. Strains
4. Bruises
5. Soft tissue rheumatism.
Interactions for Diclofenac Topical
Typical Dosage for Diclofenac Topical
Apply Diclofenac topical to the affected area, smoothing it gently onto the affected skin. Assure that enough gel is applied to adequately cover each lesion.
2 to 4g rubbed gently into affected area 3-4 times daily. Review after 14 days.
Children- Not recommended.
Schedule of Diclofenac Topical
Storage Requirements for Diclofenac Topical
Store diclofenac topical at room temperature away from moisture and heat
Effects of Missed Dosage of Diclofenac Topical
Apply the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and apply only the next regularly scheduled dose. Do not apply a double dose of this medication.
Effects of Overdose of Diclofenac Topical
Give symptomatic and supportive treatment

Home Delivery for Diclofenac Topical in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including diclofenac topical.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for diclofenac topical and other medicines and health products. Home delivery services for diclofenac topical may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take diclofenac topical only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for diclofenac topical before they complete the sale. You can get this information while placing the order for diclofenac topical with the pharmacy.

Diclofenac Topical is a generic medicine name and there are several brands available for it. Some of the brands for diclofenac topical might be better known than diclofenac topical itself. If the pharmacy that's willing to deliver medicines to your home doesn't have diclofenac topical in stock, you can ask for one of the branded alternatives for diclofenac topical.