Aceclofenac Topical Pharmacology
Aceclofenac Topical
1. It inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action).
2. It blocks degeneration and stimulates synthesis of extra cellular matrix of cartilages by inhibiting the action of different cytokines.
3. Drug and its metabolites inhibit IL-6 production by human chondrocytes. This leads to inhibition of increase of inflammatory cells in synovial tissue, inhibition of IL-1 amplification, inhibition of increased MMP synthesis and thus ensuring proteoglycan production.
4. It inhibits IL-1 and TNF production by human chondrocytes, inflammatory cells and synovial cells and therefore blocks suppression of GAG and collagen synthesis and stimulates growth factors mediated synthesis of GAG and collagen.
5. 4`-hydroxyaceclofenac a metabolite of aceclofenac inhibits pro MMP1 and pro MMP3 produced by synovial cells (Rheumatoid Synovial Cells) in serum and in synovial fluid and thus inhibits progressive joint destruction by MMPs.
6. Aceclofenac inhibits Neutrophil Adhesion & Accumulation at the inflammatory site in the early phase and thus blocks the pro-inflammatory actions of Neutrophils.
7. Aceclofenac is also an NSAID with greater COX-2 specificity
2. Local irritation.
3. Erythema.
4. Photosensitivity.
5. Pruritis
2. Hypothrombinemia
3. Liver disease
4. Before surgery
5. For external use only
6. NOT to be applied on wounds and broken skin
7. As the drugs in topical analgesics may produce irritation they should not be applied near eyes, on mucus membrane or on inflamed skin
2. Sprains.
3. Bruises.
4. Overexertion.
5. Adjunct in the management of minor stiffness or soreness associated with arthritis.
6. Rheumatism.
7. Lumbago.
8. Fibrositis.
9. Sciatica.
10. Stiffneck.
Home Delivery for Aceclofenac Topical in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including aceclofenac topical.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for aceclofenac topical and other medicines and health products. Home delivery services for aceclofenac topical may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take aceclofenac topical only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for aceclofenac topical before they complete the sale. You can get this information while placing the order for aceclofenac topical with the pharmacy.
Aceclofenac Topical is a generic medicine name and there are several brands available for it. Some of the brands for aceclofenac topical might be better known than aceclofenac topical itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aceclofenac topical in stock, you can ask for one of the branded alternatives for aceclofenac topical.
