- Medicine India
- Generic Medicines
- Pharmacology For Paracetamol + Chlorpheniramine maleate + Phenylpropanolamine
Paracetamol + Chlorpheniramine maleate + Phenylpropanolamine Pharmacology
Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineAbout Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/AMechanism of Action of Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/APharmacokinets of Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/AOnset of Action for Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/ADuration of Action for Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/AHalf Life of Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/ASide Effects of Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/AContra-indications of Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/ASpecial Precautions while taking Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/AInteractions for Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/ATypical Dosage for Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/ASchedule of Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/AStorage Requirements for Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/AEffects of Missed Dosage of Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/AEffects of Overdose of Paracetamol + Chlorpheniramine maleate + PhenylpropanolamineN/A
ParacetamolAbout ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Chlorpheniramine MaleateAbout Chlorpheniramine MaleateN/AMechanism of Action of Chlorpheniramine MaleateN/APharmacokinets of Chlorpheniramine MaleateN/AOnset of Action for Chlorpheniramine MaleateN/ADuration of Action for Chlorpheniramine MaleateN/AHalf Life of Chlorpheniramine MaleateN/ASide Effects of Chlorpheniramine MaleateN/AContra-indications of Chlorpheniramine MaleateFirst Generation alkylamine H1 Antagonist, Antihistamine.Special Precautions while taking Chlorpheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Chlorpheniramine MaleateN/AInteractions for Chlorpheniramine MaleateN/ATypical Dosage for Chlorpheniramine MaleateN/ASchedule of Chlorpheniramine MaleateN/AStorage Requirements for Chlorpheniramine MaleateN/AEffects of Missed Dosage of Chlorpheniramine MaleateN/AEffects of Overdose of Chlorpheniramine MaleateN/A
PhenylpropanolamineAbout PhenylpropanolamineAlfa-and Beta-adrenergic agonist, Phenethylamine derivative, a stimulant, decongestant,anorectic.Mechanism of Action of PhenylpropanolamineIt is a mixed acting sympathomimetic amine with predominant alpha adrenergic agonistic action. It exerts nasal decongestant action by acting through alpha adrenergic receptors in the respiratory tract mucosa; and produces vasoconstriction. It temporarily reduces the swelling associated with inflammation of nasal mucosa.
Phenylpropanolamine also suppresses the appetite control center in the hypothalamus
Pharmacokinets of PhenylpropanolamineAbsorption: Well absorbed orally, Metabolism: Metabolized in to an active metabolite in liver, Excretion: Excreted mainly through urine.Onset of Action for Phenylpropanolamine15 to 30 minutesDuration of Action for Phenylpropanolamine3 hoursHalf Life of PhenylpropanolamineN/ASide Effects of Phenylpropanolamine1. Hypertension
4. Renal failure
6. Psychotic disturbances
8. SeizuresContra-indications of Phenylpropanolamine1. Hypersensitivity to Phenylpropanolamine or other sympathomimetics
2. Coronary artery disease
6. Angle-closure glaucoma
8. Renal impairment
10. During or within 14 days of use of MAO inhibitors
11. Use as an anorexiant for children less than 12 years of age
12. Sustained-release forms during lactation and in children less than 12 years of age
Special Precautions while taking Phenylpropanolamine1. Cardiovascular disorders
2. Mild Hypertension
3. Prostatic hypertrophy
4. Psychosis or other psychiatric disorders (Phenylpropanolamine may precipitate psychiatric disorders)
5. Not drinking large amounts of caffeine-containing beverages, such as coffee, tea, or colas
6. Do not engage in driving, using machines, or doing anything else that requires mental alertness while taking medication
7. Inform the physician if cold symptoms do not improve within 7 days or if fever is present
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Phenylpropanolamine1. Nasal congestion
Interactions for PhenylpropanolamineN/ATypical Dosage for PhenylpropanolamineOral:
As decongestant: 25mg every four hours or 50mg every 8 hours daily. Not to exceed 150mg/day
Anorexiant: 25mg thrice daily; 30minutes before meals.
Extended release tablets or capsules:As decongestant: 75mg twice daily
Anorexiant: 75mg once daily in the morning.
Children (6 to 12 years): 12.5mg up to every four hours. Not to exceed 75mg/day
Children (2 to 6years): 6.25mg up to every four hours. Not to exceed 37.5mg/day
Schedule of PhenylpropanolamineHStorage Requirements for PhenylpropanolamineStore at controlled room temperature at range of 15 to 30 degree C.; in a well closed container. Protect from light.Effects of Missed Dosage of PhenylpropanolamineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PhenylpropanolamineProvide symptomatic treatment and supportive measures.Remove drug from the body by induced emesis or gastric lavage. Barbiturate sedatives are sometimes used to control excessive CNS stimulation. Monitor Cardiovascular and respiratory functions. Administer intravenous fluids to control hypotension. Correct hypertension with Intravenous phentolamine or nitrates. Perform forced diuresis by acidification of urine.
Home Delivery for Paracetamol + Chlorpheniramine maleate + Phenylpropanolamine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including paracetamol + chlorpheniramine maleate + phenylpropanolamine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for paracetamol + chlorpheniramine maleate + phenylpropanolamine and other medicines and health products. Home delivery services for paracetamol + chlorpheniramine maleate + phenylpropanolamine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take paracetamol + chlorpheniramine maleate + phenylpropanolamine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for paracetamol + chlorpheniramine maleate + phenylpropanolamine before they complete the sale. You can get this information while placing the order for paracetamol + chlorpheniramine maleate + phenylpropanolamine with the pharmacy.
Paracetamol + Chlorpheniramine maleate + Phenylpropanolamine is a generic medicine name and there are several brands available for it. Some of the brands for paracetamol + chlorpheniramine maleate + phenylpropanolamine might be better known than paracetamol + chlorpheniramine maleate + phenylpropanolamine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have paracetamol + chlorpheniramine maleate + phenylpropanolamine in stock, you can ask for one of the branded alternatives for paracetamol + chlorpheniramine maleate + phenylpropanolamine.