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- Pharmacology For Diclofenac Sodium + Dextropropoxyphene + Chlorzoxazone
Diclofenac Sodium + Dextropropoxyphene + Chlorzoxazone Pharmacology
Diclofenac Sodium + Dextropropoxyphene + Chlorzoxazone
About Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/AMechanism of Action of Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/APharmacokinets of Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/AOnset of Action for Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/ADuration of Action for Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/AHalf Life of Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/ASide Effects of Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/AContra-indications of Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/ASpecial Precautions while taking Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/AInteractions for Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/ATypical Dosage for Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/ASchedule of Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/AStorage Requirements for Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/AEffects of Missed Dosage of Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/AEffects of Overdose of Diclofenac Sodium + Dextropropoxyphene + ChlorzoxazoneN/ADiclofenac Sodium
About Diclofenac SodiumN/AMechanism of Action of Diclofenac SodiumDiclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (PGs). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. .Pharmacokinets of Diclofenac SodiumAbsorption: Diclofenac sodium is rapidly absorbed after oral administration. It undergoes first pass metabolism and its bioavailability is 50 % only. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac sodium is metabolised in the liver. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.Onset of Action for Diclofenac Sodium1- 4.5 hoursDuration of Action for Diclofenac SodiumHoursHalf Life of Diclofenac Sodium2 hoursSide Effects of Diclofenac Sodium1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13. Rash
Contra-indications of Diclofenac Sodium1.Hypersensitivity to Indomethacin and other Non steroidal anti inflammatory drugs(NSAID)
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Sodium1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 14: contraindicatedIndications for Diclofenac Sodium1.Ankylosing spondylitis
2.Acute gout
3.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
4.Osteoarthritis
5.For the relief of pain and inflammation in dental minor surgery and orthopedic
6.Dysmenorrhoea
7.Juvenile chronic arthritis
8.Migraine
Interactions for Diclofenac SodiumLithium & Digoxin : Blood levels of lithium and digoxin increased leading to enhanced efficacy and posible toxicity.
Diuretics : Inhibits diuretics but efficacy of potassium sparing diuretics enhanced.
Methotrexate : Toxicity enhanced.
Salicylates : Efficacy of salicylates reduced.
Cyclosporine : Increases nephrotoxicity of both agents.
Hydantoins : Increases serum levels resulting in toxicity.
Typical Dosage for Diclofenac SodiumAdult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Ankylosing spondylitis: 25 mg 4 times daily give an extra dose of 25 mg at bed time if necessary.
Children Juvenile rheumatoid arthritis: 0.5 - 2 mg / kg body weight / day in divided doses.
Maximum dose: 3 mg / kg body weight / day in divided doses
Schedule of Diclofenac SodiumHStorage Requirements for Diclofenac SodiumStore Diclofenac sodium at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Diclofenac SodiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Diclofenac SodiumGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.Dextropropoxyphene
About DextropropoxypheneA synthetic morphine derivative,Opioid-like agonist,optical isomer of Levopropoxyphene, Narcotic Analgesic, anti-tussive and local anesthetic.Mechanism of Action of DextropropoxypheneIt acts on the CNS Opioid receptors. It has agonist action on mu Opioid receptors. It primarily binds to the mu Opioid receptors and produce analgesia. Its CNS effects are same as morphine. It gives in combination with other Non Steroidal Anti Inflammatory Drugs or other analgesics usually.
Pharmacokinets of DextropropoxypheneAbsorption-Orally absorbed; primarily to the upper small intestine.
Distribution-Widely distributed in the body. Enters the cerebrospinal fluid and cross the placenta.
Metabolism-In liver it is metabolized by N-demethylation. Norpropoxyphene is its active metabolite. It has more half life than parent drug. It causes toxicity at sometime due to its metabolites accumulation in the body.
Excretion-It is excreted through urine.
Onset of Action for Dextropropoxyphene30 to 60 min. after oral administrationDuration of Action for Dextropropoxyphene4 to 6 hrsHalf Life of DextropropoxyphenePlasma half life is 6 to 12 hrsSide Effects of Dextropropoxyphene1. Nausea
2. Vomiting
3. Epigastric distress
4. Sedation
5. Dizziness
6. Urticaria
7. Visual disturbances
8. Physiological dependence
Contra-indications of Dextropropoxyphene1. Hypersensitivity to this drug
2. Respiratory depression
3. Children below 12 years
Special Precautions while taking Dextropropoxyphene1. In patients with hepatic failure or renal failure used cautiously
2. Patient can not drive or operate machinery after the drug administration. So the care should be taken
3. Use cautiously in patients with suicidal mentality
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Dextropropoxyphene1. Relieve moderate to severe pain in various conditions
2. Opioid withdrawal
Interactions for DextropropoxypheneBarbiturate anaesthetics: May increase respiratory and CNS depressive effects of propoxyphene.
Warfarin: Potentiation of hypoprothrombinemic effect.
Carbamazipine: May increase serum carbamzipine levels with resultant toxicity.Typical Dosage for DextropropoxypheneOral-
Adults - 65mg 3 to 4 times daily.
Schedule of DextropropoxypheneHStorage Requirements for DextropropoxypheneStore controlled room temperature i.e. between 15 and 30 degree CelsiusEffects of Missed Dosage of DextropropoxypheneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextropropoxypheneProvide supportive and symptomatic treatment. Establish artificial respiratory exchange. In the case of respiratory or cardiovascular depression administer a narcotic antagonist i.e. naloxone.Induce emesis or gastric lavage if the patient shows symptoms within 2hrs after drug administration. Avoid the risk of aspiration. For the further removal of drug, administer activated charcoal via nasogastric tube. Continue the supportive treatment and closely monitor the laboratory parameters, vital signs, neurological status closely. In some cases dialysis may be helpful for the treatment.Chlorzoxazone
About ChlorzoxazoneA benzoxazolone derivative, Centrally acting Muscle relaxant and mild sedative.Mechanism of Action of ChlorzoxazoneThis muscle relaxant works by blocking nerve impulses (or pain sensations) that are sent to your brain. It inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. It may also reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium influx.Pharmacokinets of ChlorzoxazoneAbsorption- Rapidly and completely absorbed after oral administration.
Distribution- Widely distributed in the body.
Metabolism- It is metabolized in the liver to its metabolites by glucoronide conjugation.
Excretion- It is excreted through urine.
Onset of Action for Chlorzoxazone1 hr after oral administrationDuration of Action for Chlorzoxazone3 to 4 hrsHalf Life of ChlorzoxazoneN/ASide Effects of Chlorzoxazone1. Difficulty breathing
2. Closing of your throat
3. Swelling of your lips, tongue, or face
4. Liver damage
5. Yellowing of the skin or eyes
5. Nausea
6. Abdominal pain or discomfort
7. Unusual bleeding or bruising
8. Severe fatigue
9. Stomach damage
10. Drowsiness
11. Dizziness
12. Lightheadedness
13. Discolored urine
14. Rash
Contra-indications of Chlorzoxazone1. Hypersensitivity to the drugSpecial Precautions while taking Chlorzoxazone1. Liver problems
2. Stomach problems
3. Intestinal problems
4. Any drug allergies
5. Any work which require mental alertness such as driving and machines operating
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Chlorzoxazone1. Painful skeletal muscle spasmsInteractions for ChlorzoxazoneAlcohol or other CNS depressants: Additive effect if used concomitantly.Typical Dosage for ChlorzoxazoneAdults: 250 mg-750 mg 3-4 times daily.
Children: 125 mg -500 mg 3-4 times daily.
Schedule of ChlorzoxazoneHStorage Requirements for ChlorzoxazoneStore at room temperature away from moisture and heat.Effects of Missed Dosage of ChlorzoxazoneTake the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.Effects of Overdose of ChlorzoxazoneGive symptomatic and supportive treatment. Induce emesis or gastric lavage. Administer activated charcoal to avoid further absorption of drug.Home Delivery for Diclofenac Sodium + Dextropropoxyphene + Chlorzoxazone in Your City
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Diclofenac Sodium + Dextropropoxyphene + Chlorzoxazone is a generic medicine name and there are several brands available for it. Some of the brands for diclofenac sodium + dextropropoxyphene + chlorzoxazone might be better known than diclofenac sodium + dextropropoxyphene + chlorzoxazone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have diclofenac sodium + dextropropoxyphene + chlorzoxazone in stock, you can ask for one of the branded alternatives for diclofenac sodium + dextropropoxyphene + chlorzoxazone.
