Paracetamol + Pheniramine Maleate Pharmacology

Paracetamol + Pheniramine Maleate

About Paracetamol + Pheniramine Maleate
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Mechanism of Action of Paracetamol + Pheniramine Maleate
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Pharmacokinets of Paracetamol + Pheniramine Maleate
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Onset of Action for Paracetamol + Pheniramine Maleate
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Duration of Action for Paracetamol + Pheniramine Maleate
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Half Life of Paracetamol + Pheniramine Maleate
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Side Effects of Paracetamol + Pheniramine Maleate
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Contra-indications of Paracetamol + Pheniramine Maleate
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Special Precautions while taking Paracetamol + Pheniramine Maleate
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Paracetamol + Pheniramine Maleate
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Interactions for Paracetamol + Pheniramine Maleate
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Typical Dosage for Paracetamol + Pheniramine Maleate
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Schedule of Paracetamol + Pheniramine Maleate
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Storage Requirements for Paracetamol + Pheniramine Maleate
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Effects of Missed Dosage of Paracetamol + Pheniramine Maleate
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Effects of Overdose of Paracetamol + Pheniramine Maleate
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Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Pheniramine Maleate

About Pheniramine Maleate
First generation HistamineH1 antagonist ,Alkylamine derivative, Anti histamine.
Mechanism of Action of Pheniramine Maleate
This alkyl amine derivative has peripheral H1 receptor antagonist action and compete with histamine for binding to the receptors present on bronchi, uterus etc. This inhibits the activation of receptors and corresponding allergic symptoms produced by it. Centrally the drug also has some antimuscarinic activity.
Pharmacokinets of Pheniramine Maleate
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Onset of Action for Pheniramine Maleate
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Duration of Action for Pheniramine Maleate
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Half Life of Pheniramine Maleate
19 hrs
Side Effects of Pheniramine Maleate
1. Drowsiness
2. Nervousness
3. Irritability
4. Incoordination
5. Lack of concentration
6. Dizziness
7. Tinnitus
8. Nausea
9. Vomiting
10. Difficulty in passing urine
11. Asthma
12. Wheezing
13. Swelling of the face lips or tongue
14. Hives
15. Itching
16. Skin rash
17. Fainting
Contra-indications of Pheniramine Maleate
1. Hypersensitivity to the drug or its ingredients
2. Porphyria
Special Precautions while taking Pheniramine Maleate
1. Heart disease
2. High blood pressure
3. Narrow angle glaucoma
4. Enlarged prostate gland
5. Any work which require mental alertness
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Pheniramine Maleate
1. Eczema
2. Dermatitis
3. Urticaria
4. Skin oedema
5. Itching due to insect bites
6. Photo-dermatitis
7. Rhinitis
8. Serum sickness
9. Paresis during pregnancy
10. Toxaemia and retention of placenta
11. Motion sickness
Interactions for Pheniramine Maleate
Alcohol and other CNS depressants (Hypnotics, Sedative, Tranquilizers, Antianxiety agents, Narcotic analgesics): Additive effect leading to profound CNS depression.
MAOIs: Prolong anticholinergic (drying) effects.
Anticholinergics (some) & Tricyclic Antidepressants: May have enhanced effect.
Aminoglycosides: Ototoxicity of aminoglycosides masked.
Typical Dosage for Pheniramine Maleate
Oral
Adult:15-30 mg 2 - 3 times daily.

Schedule of Pheniramine Maleate
G
Storage Requirements for Pheniramine Maleate
Stored at controlled room temperature. Protect from light and excessive heat. Keep out of reach of children.
Effects of Missed Dosage of Pheniramine Maleate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Pheniramine Maleate
Give symptomatic and supportive treatment

Home Delivery for Paracetamol + Pheniramine Maleate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for paracetamol + pheniramine maleate and other medicines and health products. Home delivery services for paracetamol + pheniramine maleate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take paracetamol + pheniramine maleate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for paracetamol + pheniramine maleate before they complete the sale. You can get this information while placing the order for paracetamol + pheniramine maleate with the pharmacy.

Paracetamol + Pheniramine Maleate is a generic medicine name and there are several brands available for it. Some of the brands for paracetamol + pheniramine maleate might be better known than paracetamol + pheniramine maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have paracetamol + pheniramine maleate in stock, you can ask for one of the branded alternatives for paracetamol + pheniramine maleate.