Nimesulide + Paracetamol + Chlorzoxazone Pharmacology

Nimesulide + Paracetamol + Chlorzoxazone

About Nimesulide + Paracetamol + Chlorzoxazone
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Mechanism of Action of Nimesulide + Paracetamol + Chlorzoxazone
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Pharmacokinets of Nimesulide + Paracetamol + Chlorzoxazone
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Onset of Action for Nimesulide + Paracetamol + Chlorzoxazone
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Duration of Action for Nimesulide + Paracetamol + Chlorzoxazone
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Half Life of Nimesulide + Paracetamol + Chlorzoxazone
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Side Effects of Nimesulide + Paracetamol + Chlorzoxazone
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Contra-indications of Nimesulide + Paracetamol + Chlorzoxazone
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Special Precautions while taking Nimesulide + Paracetamol + Chlorzoxazone
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Nimesulide + Paracetamol + Chlorzoxazone
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Interactions for Nimesulide + Paracetamol + Chlorzoxazone
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Typical Dosage for Nimesulide + Paracetamol + Chlorzoxazone
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Schedule of Nimesulide + Paracetamol + Chlorzoxazone
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Storage Requirements for Nimesulide + Paracetamol + Chlorzoxazone
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Effects of Missed Dosage of Nimesulide + Paracetamol + Chlorzoxazone
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Effects of Overdose of Nimesulide + Paracetamol + Chlorzoxazone
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Nimesulide

About Nimesulide
COX-2 selective NSAID, Analgesic,antipyretic.
Mechanism of Action of Nimesulide
This Non Steroidal Anti Inflammatory Drug reduces prostaglandin synthesis by the inhibition of cyclo oxygenase enzyme2 selectively. This is a weaker inhibition .So it produces weaker analgesic property. Its potent anti-inflammatory activity is due to its action on various stages of inflammation. This leads to the inhibition of super oxide anion formation invitro by activated neutrophil, inhibition of histamine release from tissue mast cells and basophiles. Additionally it also prevents platelet activating factor synthesis and metalloproteinase synthesis thus prevents the breakdown of osteoarthritic human cartilage. It also prevent tumor necrosis factor alpha and thus reduce the formation of cytokines. This drug can activate glucocorticoid receptors in the body.
Pharmacokinets of Nimesulide
Absorption-Completely absorbed after oral administration.
Distribution-Widely distributed in the body and extensively bind to the plasma proteins i.e.99%.
Metabolism-It is metabolized in liver to its metabolites.4-hydroxyl derivative is its one active metabolite.
Excretion - Excreted via urine and bile.
Onset of Action for Nimesulide
30 to 60 minutes
Duration of Action for Nimesulide
8-10 hours
Half Life of Nimesulide
Its plasma half life is long-nearly 2days
Side Effects of Nimesulide
1. Nausea
2. Vomiting
3. Diarrhea
4. Heart burn
5. Epigastric pain
6. Pruritis
7. Skin rash
8. Headache
9. Dizziness
10.Somnolence
Contra-indications of Nimesulide
1. Hypersensitivity to this drug
2. Active peptic ulcer
3. Hepatic impairment
Special Precautions while taking Nimesulide
1. Renal impairment
2. Heart failure
3. Alcohol abuse
4. Colitis
5. Crohns disease
6. Diverticulitis
7. Gastric ulcer
8. Diabetis mellitus
9. Hemarrhoids
10. Hepatic failure
11. Rectal irritation or bleeding
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Nimesulide
1. Painful inflammatory conditions associated with -
Musculoskeletal system, Dysmenorrhea, Thrombophlebitis, Gout
2. Dental pain
3. ENT infection
4. Osteoarthritis
5. Rheumatoid arthritis
6. Gynecological disorder
7. Low back pain
8. Post operative pain
9. Fever


Interactions for Nimesulide
Fenofibrate, Salicyclic acid, Valproic acid and Tolbutamide: These drugs displace nimesulide from the plasma binding sites.
Methotrexate and Frusemide: These drugs may be displaced from plasma proteins by nimesulide.
Warfarin: Exercise caution since efficacy may be increased.
Theophylline: Efficacy of slow release theophylline preparations reduced.
Typical Dosage for Nimesulide
Oral-
Adults - 100 mg two times daily.
Children - 5mg/kg/day divided in 2 or 3 doses.
Schedule of Nimesulide
H
Storage Requirements for Nimesulide
Store in cool, dark, dry place
Effects of Missed Dosage of Nimesulide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose

Effects of Overdose of Nimesulide
Empty the stomach if necessary. Symptomatic treatment should be given

Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Chlorzoxazone

About Chlorzoxazone
A benzoxazolone derivative, Centrally acting Muscle relaxant and mild sedative.
Mechanism of Action of Chlorzoxazone
This muscle relaxant works by blocking nerve impulses (or pain sensations) that are sent to your brain. It inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. It may also reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium influx.
Pharmacokinets of Chlorzoxazone
Absorption- Rapidly and completely absorbed after oral administration.
Distribution- Widely distributed in the body.
Metabolism- It is metabolized in the liver to its metabolites by glucoronide conjugation.
Excretion- It is excreted through urine.
Onset of Action for Chlorzoxazone
1 hr after oral administration
Duration of Action for Chlorzoxazone
3 to 4 hrs
Half Life of Chlorzoxazone
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Side Effects of Chlorzoxazone
1. Difficulty breathing
2. Closing of your throat
3. Swelling of your lips, tongue, or face
4. Liver damage
5. Yellowing of the skin or eyes
5. Nausea
6. Abdominal pain or discomfort
7. Unusual bleeding or bruising
8. Severe fatigue
9. Stomach damage
10. Drowsiness
11. Dizziness
12. Lightheadedness
13. Discolored urine
14. Rash
Contra-indications of Chlorzoxazone
1. Hypersensitivity to the drug
Special Precautions while taking Chlorzoxazone
1. Liver problems
2. Stomach problems
3. Intestinal problems
4. Any drug allergies
5. Any work which require mental alertness such as driving and machines operating
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Chlorzoxazone
1. Painful skeletal muscle spasms
Interactions for Chlorzoxazone
Alcohol or other CNS depressants: Additive effect if used concomitantly.
Typical Dosage for Chlorzoxazone
Adults: 250 mg-750 mg 3-4 times daily.
Children: 125 mg -500 mg 3-4 times daily.
Schedule of Chlorzoxazone
H
Storage Requirements for Chlorzoxazone
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Chlorzoxazone
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.
Effects of Overdose of Chlorzoxazone
Give symptomatic and supportive treatment. Induce emesis or gastric lavage. Administer activated charcoal to avoid further absorption of drug.

Home Delivery for Nimesulide + Paracetamol + Chlorzoxazone in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nimesulide + paracetamol + chlorzoxazone and other medicines and health products. Home delivery services for nimesulide + paracetamol + chlorzoxazone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nimesulide + paracetamol + chlorzoxazone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nimesulide + paracetamol + chlorzoxazone before they complete the sale. You can get this information while placing the order for nimesulide + paracetamol + chlorzoxazone with the pharmacy.

Nimesulide + Paracetamol + Chlorzoxazone is a generic medicine name and there are several brands available for it. Some of the brands for nimesulide + paracetamol + chlorzoxazone might be better known than nimesulide + paracetamol + chlorzoxazone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nimesulide + paracetamol + chlorzoxazone in stock, you can ask for one of the branded alternatives for nimesulide + paracetamol + chlorzoxazone.