Baclofen Pharmacology


About Baclofen
Derivative of GABA ,Chlorophenyl derivative, Skeletal muscle relaxant,antispastic agent and in trigeminal neuralgia.
Mechanism of Action of Baclofen
It inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABA-B receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Baclofen also exerts an antinoceptive effect
Pharmacokinets of Baclofen
Absorption- Rapidly and completely absorbed after oral administration
Distribution- 30% bound to the plasma proteins. Crosses the blood-brain barrier Metabolism- It is metabolized in the liver by deamination to ?- (p-chlorophenyl)-gamma-hydroxybutyric acid which is pharmacologically inactive.
Excretion- Excreted through urine and feces
Onset of Action for Baclofen
1 to 3 hour after administration
Duration of Action for Baclofen
8 hours
Half Life of Baclofen
The elimination half-life is 3 to4 hours in plasma and about 5 hours in CSF
Side Effects of Baclofen
1. Difficulty breathing.
2. Swelling of your lips, tongue, and face.
3. Hives
4. Seizures.
5. Irregular heartbeat.
6. Drowsiness.
7. Dizziness.
8. Weakness.
9. Unusual fatigue.
10. Headache.
11. Constipation.
12. Stuffy nose.
13. Blurred vision.
14. Rash.
15. Frequent urination.
Contra-indications of Baclofen
1. Hypersensitivity to baclofen.
2. Rheumatic disorders
Special Precautions while taking Baclofen
1. Type 2 diabetes mellitus.
2. Epilepsy.
3. Kidney disease.
4. Mental or emotional problems.
5. Stroke or other brain disease
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution
Indications for Baclofen
1. Spasticity in multiple sclerosis.
2. Spasticity in spinal cord diseases (degenerative, traumatic, infectious or of unknown origin like amyotrophic lateral sclerosis)
3. Transverse myelitis
4. Spastic spinal paralysis.
5. Muscle spasticity of cerebral origin e.g. cerebral palsy
Interactions for Baclofen
Typical Dosage for Baclofen
Initial dose-15 mg/day
Maintenance dose - 30-75 mg/day in divided doses.
0.75-2 mg/kg/day in divided doses
Schedule of Baclofen
Storage Requirements for Baclofen
Store below 30?C. Protect from heat, light, and moisture.
Effects of Missed Dosage of Baclofen
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Baclofen
Empty the stomach promptly by induced emesis followed by gastric lavage. Administer charcoal and if necessary saline laxatives to reduce the further absorption of drugs

Home Delivery for Baclofen in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including baclofen.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for baclofen and other medicines and health products. Home delivery services for baclofen may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take baclofen only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for baclofen before they complete the sale. You can get this information while placing the order for baclofen with the pharmacy.

Baclofen is a generic medicine name and there are several brands available for it. Some of the brands for baclofen might be better known than baclofen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have baclofen in stock, you can ask for one of the branded alternatives for baclofen.