Diclofenac potassium + Serratiopeptidase + Tizanidine Pharmacology

Diclofenac potassium + Serratiopeptidase + Tizanidine

About Diclofenac potassium + Serratiopeptidase + Tizanidine
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Mechanism of Action of Diclofenac potassium + Serratiopeptidase + Tizanidine
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Pharmacokinets of Diclofenac potassium + Serratiopeptidase + Tizanidine
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Onset of Action for Diclofenac potassium + Serratiopeptidase + Tizanidine
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Duration of Action for Diclofenac potassium + Serratiopeptidase + Tizanidine
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Half Life of Diclofenac potassium + Serratiopeptidase + Tizanidine
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Side Effects of Diclofenac potassium + Serratiopeptidase + Tizanidine
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Contra-indications of Diclofenac potassium + Serratiopeptidase + Tizanidine
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Special Precautions while taking Diclofenac potassium + Serratiopeptidase + Tizanidine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Diclofenac potassium + Serratiopeptidase + Tizanidine
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Interactions for Diclofenac potassium + Serratiopeptidase + Tizanidine
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Typical Dosage for Diclofenac potassium + Serratiopeptidase + Tizanidine
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Schedule of Diclofenac potassium + Serratiopeptidase + Tizanidine
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Storage Requirements for Diclofenac potassium + Serratiopeptidase + Tizanidine
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Effects of Missed Dosage of Diclofenac potassium + Serratiopeptidase + Tizanidine
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Effects of Overdose of Diclofenac potassium + Serratiopeptidase + Tizanidine
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Diclofenac Potassium

About Diclofenac Potassium
NSAID, anti-inflammatory ,antipyretic and analgesic.
Mechanism of Action of Diclofenac Potassium
Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.
Pharmacokinets of Diclofenac Potassium
Absorption: Diclofenac potassium is rapidly absorbed after oral administration. It undergoes first pass metabolism. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac potassium is metabolised in the liver to mainly 4 hydroxy Diclofenac. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.
Onset of Action for Diclofenac Potassium
Analgesic action: with in 60 minutes and Antirheumatic action with in 2 weeks
Duration of Action for Diclofenac Potassium
12hours
Half Life of Diclofenac Potassium
1-2 hours
Side Effects of Diclofenac Potassium
1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13.Rash
Contra-indications of Diclofenac Potassium
1.Hypersensitivity to Diclofenac and other Non steroidal anti inflammatory drugs(((NSAID)))
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Potassium
1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
CHILDREN below 14: contraindicated
Indications for Diclofenac Potassium
1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of pain and inflammation in dental minor surgery and orthopedic
7.Dysmenorrhoea
8.Migraine
Interactions for Diclofenac Potassium
N/A
Typical Dosage for Diclofenac Potassium
Adult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Schedule of Diclofenac Potassium
H
Storage Requirements for Diclofenac Potassium
Store Diclofenac potassium at room temperature in a tightly closed light resistant container.
Effects of Missed Dosage of Diclofenac Potassium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Diclofenac Potassium
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Serratiopeptidase

About Serratiopeptidase
A proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.
Mechanism of Action of Serratiopeptidase
This anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.
Pharmacokinets of Serratiopeptidase
Orally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.
Onset of Action for Serratiopeptidase
N/A
Duration of Action for Serratiopeptidase
8 to 10 hrs
Half Life of Serratiopeptidase
N/A
Side Effects of Serratiopeptidase
1. Hypersensitivity
2. Anorexia
3. Gastric discomfort
4. Nausea
5. Vomiting
6. Epistaxis
7. Diarrhoea
8. Skin rash
Contra-indications of Serratiopeptidase
1. Hypersensitivity to this drug
2. Blood coagulation disorder
Special Precautions while taking Serratiopeptidase
1. In patients with renal failure or hepatic failure
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Serratiopeptidase
1. Antiinflammatory
2. Antiswelling
3. Anti- rheumatoid
4. To promote transfer of antibiotics to the site of action
5. To promote lysis and discharge of sputum and pus
6. Bronchitis
7. Fibrocystic breast swelling
8. Sinusitis
9. Cough
10. Laryngitis
11. Fibromyalgia
12. Emphysema
13. Gout
Interactions for Serratiopeptidase
N/A
Typical Dosage for Serratiopeptidase
Oral-
Adults-5 to 10mg tab every 3 times daily.
10- 30 mg tab /day.
Schedule of Serratiopeptidase
N/A
Storage Requirements for Serratiopeptidase
Store below 25 degree Celsius, protect from light and moisture.
Effects of Missed Dosage of Serratiopeptidase
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Serratiopeptidase
Give supportive measures and symptomatic treatment.

Tizanidine

About Tizanidine
A centrally acting a-2 adrenergic agonist, Centrally acting muscle relaxant (short-acting).
Mechanism of Action of Tizanidine
This drug is a centrally acting alpha2 agonist at alpha2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. This results the blocking of nerve impulses (or pain sensations) that are sent to your brain.
Pharmacokinets of Tizanidine
Absorption- Completely absorbed after oral administration.
Distribution- Widely distributed throughout the body. 30% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted through urine.
Onset of Action for Tizanidine
1 to 2 hrs after oral administration
Duration of Action for Tizanidine
N/A
Half Life of Tizanidine
N/A
Side Effects of Tizanidine
1. Dizziness
2. Upset stomach
3. Vomiting
4. Tingling sensation in the arms, legs, hands, and feet
5. Dry mouth
6. Increased muscle spasms
7. Yellowing of the skin or eyes
8. Unexplained flu-like symptoms
Contra-indications of Tizanidine
1. Contraindicated in patients with hypersensitivity to the drug or any ingredients of it
Special Precautions while taking Tizanidine
1. Kidney disease
2. Liver disease
3. Low blood pressure or are on medication to treat high blood pressure
4. Birth control pills use
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Tizanidine
1. Painful muscle spasm associated with static and functional disorders of the spine
2. Following surgery for disc prolapse/osteoarthritis of the hip
Interactions for Tizanidine
Alcohol & other CNS depressants : CNS effects of tizanidine potentiated.
Typical Dosage for Tizanidine
Oral-
Adult-
Muscle spasm - 2 mg thrice a day.
Spasticity- Initial dose 6 mg/day in 3 divided doses, then increase stepwise to 12-36 mg/day.
Schedule of Tizanidine
N/A
Storage Requirements for Tizanidine
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Tizanidine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tizanidine
Give symptomatic and supportive treatment.

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