Tizanidine + Mefenamic acid Pharmacology

Tizanidine + Mefenamic acid

About Tizanidine + Mefenamic acid
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Mechanism of Action of Tizanidine + Mefenamic acid
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Pharmacokinets of Tizanidine + Mefenamic acid
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Onset of Action for Tizanidine + Mefenamic acid
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Duration of Action for Tizanidine + Mefenamic acid
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Half Life of Tizanidine + Mefenamic acid
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Side Effects of Tizanidine + Mefenamic acid
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Contra-indications of Tizanidine + Mefenamic acid
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Special Precautions while taking Tizanidine + Mefenamic acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Tizanidine + Mefenamic acid
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Interactions for Tizanidine + Mefenamic acid
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Typical Dosage for Tizanidine + Mefenamic acid
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Schedule of Tizanidine + Mefenamic acid
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Storage Requirements for Tizanidine + Mefenamic acid
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Effects of Missed Dosage of Tizanidine + Mefenamic acid
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Effects of Overdose of Tizanidine + Mefenamic acid
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Tizanidine

About Tizanidine
A centrally acting a-2 adrenergic agonist, Centrally acting muscle relaxant (short-acting).
Mechanism of Action of Tizanidine
This drug is a centrally acting alpha2 agonist at alpha2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. This results the blocking of nerve impulses (or pain sensations) that are sent to your brain.
Pharmacokinets of Tizanidine
Absorption- Completely absorbed after oral administration.
Distribution- Widely distributed throughout the body. 30% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted through urine.
Onset of Action for Tizanidine
1 to 2 hrs after oral administration
Duration of Action for Tizanidine
N/A
Half Life of Tizanidine
N/A
Side Effects of Tizanidine
1. Dizziness
2. Upset stomach
3. Vomiting
4. Tingling sensation in the arms, legs, hands, and feet
5. Dry mouth
6. Increased muscle spasms
7. Yellowing of the skin or eyes
8. Unexplained flu-like symptoms
Contra-indications of Tizanidine
1. Contraindicated in patients with hypersensitivity to the drug or any ingredients of it
Special Precautions while taking Tizanidine
1. Kidney disease
2. Liver disease
3. Low blood pressure or are on medication to treat high blood pressure
4. Birth control pills use
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Tizanidine
1. Painful muscle spasm associated with static and functional disorders of the spine
2. Following surgery for disc prolapse/osteoarthritis of the hip
Interactions for Tizanidine
Alcohol & other CNS depressants : CNS effects of tizanidine potentiated.
Typical Dosage for Tizanidine
Oral-
Adult-
Muscle spasm - 2 mg thrice a day.
Spasticity- Initial dose 6 mg/day in 3 divided doses, then increase stepwise to 12-36 mg/day.
Schedule of Tizanidine
N/A
Storage Requirements for Tizanidine
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Tizanidine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tizanidine
Give symptomatic and supportive treatment.

Mefenamic Acid

About Mefenamic Acid
NSAID, Analgesic,antiinflammatory.
Mechanism of Action of Mefenamic Acid
Mefenamic acid has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other analgesics. Mefenamic acid inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.
Pharmacokinets of Mefenamic Acid
Absorption: Mefenamic acid is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Mefenamic acid and its metabolites are excreted mainly in the urine.
Onset of Action for Mefenamic Acid
1-2 hours.
Duration of Action for Mefenamic Acid
6 hours.
Half Life of Mefenamic Acid
2-4 hours.
Side Effects of Mefenamic Acid
1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Peptic ulcer
9.Dyspepsia
10.Headache
11.Flatulence
12.Drowsiness
13.Insomnia
14.Agranulocytosis
15.Aplastic anaemia
16.Thrombocytopenia
17.Dizziness
18.Rash
Contra-indications of Mefenamic Acid
1.Hypersensitivity to Mefenamic acid and other NSAIDs
2.Inflammatory bowel disease
3.Peptic ulcer
Special Precautions while taking Mefenamic Acid
1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Patient on anticoagulant therapy
7.Heart failure
8.Myocardial infarction
9.Stroke
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Below 14 years: contraindicated
NEONATES: used only to close the patent ductus arteriosus as IV form only
Indications for Mefenamic Acid
1.Muscular aches
2.Primary Dysmenorrhoea
3.Headaches
4.Acute gout
5.Dental pain
6.Patent ductus arteriosus
Interactions for Mefenamic Acid
N/A
Typical Dosage for Mefenamic Acid
Adult: initial dose: 500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children above 14 years:
500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children below 14 years: not recommended.


Schedule of Mefenamic Acid
H
Storage Requirements for Mefenamic Acid
Store Mefenamic acid at room temperature in a tightly closed light resistant container.
Effects of Missed Dosage of Mefenamic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mefenamic Acid
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

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Tizanidine + Mefenamic acid is a generic medicine name and there are several brands available for it. Some of the brands for tizanidine + mefenamic acid might be better known than tizanidine + mefenamic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tizanidine + mefenamic acid in stock, you can ask for one of the branded alternatives for tizanidine + mefenamic acid.