Tizanidine + Valdecoxib Pharmacology

Tizanidine + Valdecoxib

About Tizanidine + Valdecoxib
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Mechanism of Action of Tizanidine + Valdecoxib
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Pharmacokinets of Tizanidine + Valdecoxib
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Onset of Action for Tizanidine + Valdecoxib
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Duration of Action for Tizanidine + Valdecoxib
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Half Life of Tizanidine + Valdecoxib
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Side Effects of Tizanidine + Valdecoxib
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Contra-indications of Tizanidine + Valdecoxib
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Special Precautions while taking Tizanidine + Valdecoxib
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Tizanidine + Valdecoxib
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Interactions for Tizanidine + Valdecoxib
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Typical Dosage for Tizanidine + Valdecoxib
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Schedule of Tizanidine + Valdecoxib
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Storage Requirements for Tizanidine + Valdecoxib
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Effects of Missed Dosage of Tizanidine + Valdecoxib
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Effects of Overdose of Tizanidine + Valdecoxib
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Tizanidine

About Tizanidine
A centrally acting a-2 adrenergic agonist, Centrally acting muscle relaxant (short-acting).
Mechanism of Action of Tizanidine
This drug is a centrally acting alpha2 agonist at alpha2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. This results the blocking of nerve impulses (or pain sensations) that are sent to your brain.
Pharmacokinets of Tizanidine
Absorption- Completely absorbed after oral administration.
Distribution- Widely distributed throughout the body. 30% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted through urine.
Onset of Action for Tizanidine
1 to 2 hrs after oral administration
Duration of Action for Tizanidine
N/A
Half Life of Tizanidine
N/A
Side Effects of Tizanidine
1. Dizziness
2. Upset stomach
3. Vomiting
4. Tingling sensation in the arms, legs, hands, and feet
5. Dry mouth
6. Increased muscle spasms
7. Yellowing of the skin or eyes
8. Unexplained flu-like symptoms
Contra-indications of Tizanidine
1. Contraindicated in patients with hypersensitivity to the drug or any ingredients of it
Special Precautions while taking Tizanidine
1. Kidney disease
2. Liver disease
3. Low blood pressure or are on medication to treat high blood pressure
4. Birth control pills use
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Tizanidine
1. Painful muscle spasm associated with static and functional disorders of the spine
2. Following surgery for disc prolapse/osteoarthritis of the hip
Interactions for Tizanidine
Alcohol & other CNS depressants : CNS effects of tizanidine potentiated.
Typical Dosage for Tizanidine
Oral-
Adult-
Muscle spasm - 2 mg thrice a day.
Spasticity- Initial dose 6 mg/day in 3 divided doses, then increase stepwise to 12-36 mg/day.
Schedule of Tizanidine
N/A
Storage Requirements for Tizanidine
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Tizanidine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tizanidine
Give symptomatic and supportive treatment.

Valdecoxib

About Valdecoxib
NSAID,a COX-2 inhibitor, a diaryl substituted isoxazole, Analgesic,antiinflammatory,antiarthritic.
Mechanism of Action of Valdecoxib
This NSAID inhibit COX2 enzyme selectively (COX-2 is only produced in response to tissue injury and causes tissue inflammation, and thus pain. It works by converting arachidonic acid into a specific prostaglandin which communicates the need for inflammation to the surrounding tissue). This results the anti-inflammatory action.
Pharmacokinets of Valdecoxib
Absorption- Well absorbed after oral administration.
Distribution- Widely distributed in the body as its plasma protein bound form. 98% bound to the plasma proteins.
Metabolism-It is metabolized in the liver.
Excretion- Excreted through urine and faeces.
Onset of Action for Valdecoxib
N/A
Duration of Action for Valdecoxib
N/A
Half Life of Valdecoxib
N/A
Side Effects of Valdecoxib
1. Diarrhea
2. Constipation
3. Sore throat
4. Cough
5. Runny nose
6. Fever
7. Blisters
8. Hives
9. Itching
10. Swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs
11. Difficulty in breathing or swallowing
12. Hoarseness
13. Pale skin
14. Fast heartbeat
15. Weight gain
16. Upset stomach
17. Tiredness
18. Pain in the right upper part of the stomach
19. Flu-like symptoms
20. Cloudy, discolored, or bloody urine
21. Back pain
22. Difficult or painful urination
Contra-indications of Valdecoxib
1. Hypersensitivity to the drug
2. Hepatic insufficiency
3. Renal insufficiency
Special Precautions while taking Valdecoxib
1. Alcohol abuse
2. Bleeding problems
3. Stomach ulcer
4. Tobacco abuse
5. Anemia
6. Asthma
7. Dehydration
8. Fluid retention (swelling of feet or lower legs)
9. High blood pressure
10. Kidney disease
11. Liver disease
12. Coronary artery bypass graft (CABG) surgery
13. Heart disease
Pregnancy Related Information
Contraindicated

Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Valdecoxib
1. Dysmenorrhea (pain with your menstrual period)
2. Osteoarthritis
3. Rheumatoid arthritis
4. Acute gout
Interactions for Valdecoxib
Coadministration with fluconazole and ketoconazole : Enhances the total plasma exposure (AUC) of valdecoxib.
Coadministration with warfarin: Causes a significant increase in plasma exposure of warfarin.
Typical Dosage for Valdecoxib
Oral-
Adults-
Osteoarthritis & rheumatoid arthritis - 10mg once a day.
Dysmenorrhea- 20- 40mg daily.
Schedule of Valdecoxib
N/A
Storage Requirements for Valdecoxib
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Valdecoxib
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Valdecoxib
Give symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.

Home Delivery for Tizanidine + Valdecoxib in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tizanidine + valdecoxib and other medicines and health products. Home delivery services for tizanidine + valdecoxib may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tizanidine + valdecoxib only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tizanidine + valdecoxib before they complete the sale. You can get this information while placing the order for tizanidine + valdecoxib with the pharmacy.

Tizanidine + Valdecoxib is a generic medicine name and there are several brands available for it. Some of the brands for tizanidine + valdecoxib might be better known than tizanidine + valdecoxib itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tizanidine + valdecoxib in stock, you can ask for one of the branded alternatives for tizanidine + valdecoxib.