Pipercuronium Pharmacology


About Pipercuronium
Mechanism of Action of Pipercuronium
This nondepolarizing neuromuscular blocker competes with acetylcholine for receptor sites at the motor end plate, thereby reducing the response of the end plate to acetylcholine. This results the skeletal muscle relaxation.
General anaesthesia: It is often administered during the induction of anaesthesia to relax muscles of the jaw, neck and airway and thereby facilitate laryngoscopy and endotracheal intubation. Following induction, continued muscle relaxation is required for many procedures to aid surgical exposure and to provide additional insurance of immobility.
Pharmacokinets of Pipercuronium
Distribution- Moderately distributed in the body.
Metabolism- 20% to 40% metabolized in the liver to its active metabolite 3-desacetyl pipecuronium.
Excretion- Unchanged and changed drugs are excreted through urine.
Onset of Action for Pipercuronium
1 to 2 minute.
Duration of Action for Pipercuronium
24 minute.
Half Life of Pipercuronium
Side Effects of Pipercuronium
1. Hypotension
2. Bradycardia
3. Hypertension
4. Myocardial ischemia
5. Thrombosis
6. Atrial filtration
7. Ventricular extrasystole
8. Anuria
9. Dyspnoea
10. Respiratory depression
11. Rash
12. Urticaria
13. Prolonged muscle weakness
Contra-indications of Pipercuronium
1.Hypersensitivity to the drug
Special Precautions while taking Pipercuronium
1. Myasthenia gravis
2. Renal function impairment
3. Severe obesity
4. Malignant hyperthermia
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Pipercuronium
1. Medium acting non-depolarizing muscle relaxation in surgical anaesthesia
Interactions for Pipercuronium
Inhalational anaesthetics: Volatile inhalational anaesthetics may enhance effect.
Antiarrhythmic: Quinidine may enhance effect.
Antibacterials: Aminoglycosides, lincosamide, polymyxins and rarely tetracyclines may enhance effect.
Typical Dosage for Pipercuronium
Adult and children: 0.07-0.085 mg/kg.
Initial dose after intubating with succinylcholine: 0.05mg/kg. Incremental dose: 0.01-0.015 mg/kg.
Schedule of Pipercuronium
Storage Requirements for Pipercuronium
Store at controlled room temperature (20 to 30 degree C).
Effects of Missed Dosage of Pipercuronium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Pipercuronium
Give symptomatic and supportive treatment. Monitor vital signs closely.

Home Delivery for Pipercuronium in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pipercuronium.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pipercuronium and other medicines and health products. Home delivery services for pipercuronium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take pipercuronium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pipercuronium before they complete the sale. You can get this information while placing the order for pipercuronium with the pharmacy.

Pipercuronium is a generic medicine name and there are several brands available for it. Some of the brands for pipercuronium might be better known than pipercuronium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pipercuronium in stock, you can ask for one of the branded alternatives for pipercuronium.