D-tubocurarine Pharmacology


About D-tubocurarine
Benzylisoquinoline type alkaloid,Anticholinergic(nicotinic antagonist ), long acting competitive nondepolarizing neuromuscular blocker, Skeletal muscle relaxants.
Mechanism of Action of D-tubocurarine
D-tubocurarine is a long acting; competitive neuromuscular blocker competes with acetylcholine for receptor sites at the motor end plate, thereby reducing the response of the end plate to acetylcholine. This results the skeletal muscle relaxation. It also has Histamine releasing and ganglionic blocking properties.
Pharmacokinets of D-tubocurarine
Absorption: It is completely absorbed after parenteral administration. Distribution: drug is rapidly reaches the site action. It is mainly distributed in extra cellular fluid.40 - 50 %is distributed in protein bound form. Metabolism: It undergoes metabolism in the liver.
Excretion: It is mainly excreted in urine.
Onset of Action for D-tubocurarine
IV: 1minute; IM: 10 - 25minute
Duration of Action for D-tubocurarine
25 - 90 minute
Half Life of D-tubocurarine
Side Effects of D-tubocurarine
4.Respiratory depression
6.Muscle pain
7.Increased saliva
Contra-indications of D-tubocurarine
Hypersensitivity to D-Tubocurarine
Special Precautions while taking D-tubocurarine
1.Kidney disease
2.Pulmonary dysfunction
4.Myasthenia gravis
5.Collagen disease
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for D-tubocurarine
1.General anesthesia
2.To facilitate tracheal intubation
3.Skeletal muscle relaxation during surgery
4.Diagnosis of Tubocurarine
Interactions for D-tubocurarine
Typical Dosage for D-tubocurarine
IM or IV
Dose is individualized
6 - 9 mg followed by 3 - 4.5 mg in 3 - 5minutes if needed 3mg may be given during prolonged anaesthesia.
Diagnosis of Myasthenia gravis:0.165 mg/kg

Schedule of D-tubocurarine
Storage Requirements for D-tubocurarine
Store at room temperature below 25 degree C in a well closed container. Protect from moisture. Keep out of reach of children
Effects of Missed Dosage of D-tubocurarine
The doctor should be informed immediately if a dose is missed
Effects of Overdose of D-tubocurarine
Provide symptomatic treatment and supportive measures.

Home Delivery for D-tubocurarine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including d-tubocurarine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for d-tubocurarine and other medicines and health products. Home delivery services for d-tubocurarine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take d-tubocurarine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for d-tubocurarine before they complete the sale. You can get this information while placing the order for d-tubocurarine with the pharmacy.

D-tubocurarine is a generic medicine name and there are several brands available for it. Some of the brands for d-tubocurarine might be better known than d-tubocurarine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have d-tubocurarine in stock, you can ask for one of the branded alternatives for d-tubocurarine.