Doxacurium Pharmacology


About Doxacurium
Peripherally long acting,non depolarizing,competitive neuromuscular blocker, Skeletal muscle relaxant.
Mechanism of Action of Doxacurium
Doxacurium is a long acting, non depolarizing, competitive neuromuscular blocker competes with acetylcholine for receptor sites at the motor end plate, thereby reducing the response of the end plate to acetylcholine. This results the skeletal muscle relaxation.
Pharmacokinets of Doxacurium
Absorption: It is rapidly absorbed after parenteral administration. Distribution: Only a very small amount is distributed in protein bound form. Metabolism: It does not undergo metabolism. Excretion: Drug is excreted mainly in urine and bile.
Onset of Action for Doxacurium
2 minute
Duration of Action for Doxacurium
Half Life of Doxacurium
Side Effects of Doxacurium
2.Respiratory depression
4.Muscle weakness
Contra-indications of Doxacurium
Hypersensitivity to Doxacurium
Special Precautions while taking Doxacurium
1.Metastatic cancer
2.Electrolyte disturbances
3.Neuromuscular diseases
4.Myasthenia gravis
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Below 2years:Contraindicated
Indications for Doxacurium
1.General anesthesia
2.To facilitate tracheal intubation
3.Skeletal muscle relaxation during surgery
Interactions for Doxacurium
Typical Dosage for Doxacurium
Dosage is highly individualized
Adult:0.05mg/kg body weight as rapid IV
Maintenance dose:0.005mg/kg and 0.01mg/kgprolong the neuromuscular blockade for 30minutes and 45 minutes respectively
Children:0.03mg/kg - 0.05mg/kg body weight
Schedule of Doxacurium
Storage Requirements for Doxacurium
Store at room temperature below 25 degree C in a well closed container. Protect from moisture. Keep out of reach of children
Effects of Missed Dosage of Doxacurium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Doxacurium
Provide symptomatic treatment and supportive measures..

Home Delivery for Doxacurium in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including doxacurium.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for doxacurium and other medicines and health products. Home delivery services for doxacurium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take doxacurium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for doxacurium before they complete the sale. You can get this information while placing the order for doxacurium with the pharmacy.

Doxacurium is a generic medicine name and there are several brands available for it. Some of the brands for doxacurium might be better known than doxacurium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have doxacurium in stock, you can ask for one of the branded alternatives for doxacurium.