Dantrolene sodium Pharmacology

Dantrolene sodium

About Dantrolene sodium
Mechanism of Action of Dantrolene sodium
Dantrolene is s skeletal muscle relaxant which differs from the classical neuromuscular blocking drugs. It inhibits the release of Calcium from sarcoplasmic reticulam and suppresses excitation contraction coupling. It reduces the calcium level associated with malignant hyperthermia crises.
Pharmacokinets of Dantrolene sodium
Absorption: Bioavailability is only 35% after oral administration. Metabolism: It rapidly undergoes hydrolysis by pseudocholinesterase enzyme in the liver. Excretion: Metabolites are excreted mainly in urine and bile.
Onset of Action for Dantrolene sodium
Duration of Action for Dantrolene sodium
Half Life of Dantrolene sodium
Side Effects of Dantrolene sodium
3.Light headedness
14.Urinary frequency

Contra-indications of Dantrolene sodium
1.Hypersensitivity to Dantrolene
2.Spasms in Rheumatic disorder
3.Liver disease
Special Precautions while taking Dantrolene sodium
1.Cardiac disease
2.Impaired pulmonary function
3.Patient on Estrogen therapy
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
May be used
Below age 5 :Use with caution
Indications for Dantrolene sodium
1. Spasticity resulting from upper motor neuron lesions such as spinal cord injury, stroke, multiple sclerosis, cerebral palsy
Interactions for Dantrolene sodium
Typical Dosage for Dantrolene sodium
Adult: 25mg/day if needed dose can be increased by 25mg every 4 - 7 days up to 400mg/day in 4 divided doses.
Above 5 years: 0.5mg/kg 2 times daily, if needed dose can be gradually increased by 0.5mg/kg up to 3mg/kg 2 - 4 times daily. Maximum dose: 400 mg/day
Schedule of Dantrolene sodium
Storage Requirements for Dantrolene sodium
Store at room temperature below 25 degree C in a well closed container. Protect from moisture. Keep out of reach of children
Effects of Missed Dosage of Dantrolene sodium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dantrolene sodium
Provide symptomatic treatment and supportive measures. Gastric lavage can be done to remove the drugs.

Home Delivery for Dantrolene sodium in Your City

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Dantrolene sodium is a generic medicine name and there are several brands available for it. Some of the brands for dantrolene sodium might be better known than dantrolene sodium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dantrolene sodium in stock, you can ask for one of the branded alternatives for dantrolene sodium.