Alendronate Sodium Pharmacology

Alendronate Sodium

About Alendronate Sodium
Bisphosphonate Derivative, Bone resorption inhibitor.

Mechanism of Action of Alendronate Sodium
It preferentially localized to the sites of action and inhibits prenylation of GTP-binding proteins involved in cytoskeletal organization, membrane ruffling and vesicle movement. This results by osteoclasts inactivation, impaired vesicle fusion and enhanced apoptosis (bone resorption inhibition).
Pharmacokinets of Alendronate Sodium
Absorption- Poorly absorbed after oral administration
Distribution- Widely distributed into soft tissues and then redistributed into bone.78% bound to the plasma proteins
Metabolism- Doesn`t metabolized
Excretion- Excreted through urine as unchanged form
Onset of Action for Alendronate Sodium
Duration of Action for Alendronate Sodium
Half Life of Alendronate Sodium
Side Effects of Alendronate Sodium
1. Nausea.
2. Dyspepsia.
3. Abdominal cramps.
4. Flatulence.
5. Diarrhea.
6. Gastric and Duodenal ulceration.
7. Osteonecrosis
8. Skin rash.
9. Stevens-Johnson syndrome.
10. Epidermal necrolysis.
11. Uveitis.
12. Scleritis.

Contra-indications of Alendronate Sodium
1. Hypersensitivity to the drug.
2. Dysphasia.
3. Symptomatic esophageal diseases.
4. Frequent heartburn.
5. Gastritis.
6. Gastro esophageal reflux disease
7. Hiatal hernia.
8. Ulcers.
9. Renal function.
10. Duodenitis.
Special Precautions while taking Alendronate Sodium
1. Digestion problems.
2. Esophagus problems.
3. Intestine problems.
4. Stomach problems.
5. Kidney problems

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Alendronate Sodium
1. Osteoporosis
2. Paget`s disease

Interactions for Alendronate Sodium
Asprin: Risks of upper GI adverse effects increased.
Calcium supplements antacids: Interfere with absorption of alendronate.
Typical Dosage for Alendronate Sodium
For osteoporosis:10-30mg daily
For corticosteroid-induced osteoporosis: 5 - 10 mg daily
Paget`s disease of bone: 40mg daily for 6 months
All doses are taken with water at least 30 minutes before first food, beverage, or medication of the day

Schedule of Alendronate Sodium
Storage Requirements for Alendronate Sodium
Store at controlled room temperature. Keep away from light and moisture.
Effects of Missed Dosage of Alendronate Sodium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Alendronate Sodium
Give symptomatic and supportive treatment. Administer antacids or milk to prevent the adverse effects

Home Delivery for Alendronate Sodium in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including alendronate sodium.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for alendronate sodium and other medicines and health products. Home delivery services for alendronate sodium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take alendronate sodium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for alendronate sodium before they complete the sale. You can get this information while placing the order for alendronate sodium with the pharmacy.

Alendronate Sodium is a generic medicine name and there are several brands available for it. Some of the brands for alendronate sodium might be better known than alendronate sodium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have alendronate sodium in stock, you can ask for one of the branded alternatives for alendronate sodium.