Raloxifene Pharmacology


About Raloxifene
Selective estrogen-receptro modulator (SERM), Benzothiophene derivative, Osteoporosis in postmenopausal women.
Mechanism of Action of Raloxifene
Raloxifene is a selective estrogen-receptor modulator (SERM) that has been approved for use in the prevention and treatment of osteoporosis in postmenopausal women. A SERM interacts with estrogen receptors, functioning as an agonist in some tissues and an antagonist in other tissues. Raloxifene has estrogen agonist-like effects on bone and on cholesterol metabolism and antagonist-like effects on the endometrium and breasts; it produces some of the beneficial effects of estrogen without the possible adverse effects.
Pharmacokinets of Raloxifene
Absorption- Raloxifene is rapidly absorbed (about 60%) after oral administration and its bioavailability is about 2%.
Distribution-Drug and its metabolites are widely distributed in the body in protein bound form.
Metabolism: It undergoes hepatic glucuronidation.
Excretion- Excreted primarily in the faeces
Onset of Action for Raloxifene
Duration of Action for Raloxifene
24 hours
Half Life of Raloxifene
28 hours
Side Effects of Raloxifene
1. Hot flushes
2. Infection
3. Flu syndrome
4. Nausea
5. Vomiting
6. Leg cramps
7. Dyspepsia
8. Weight gain
9. Arthralgia
10. Myalgia
11. Sinusitis
12. Pharyngitis
13. Peripheral edema
Contra-indications of Raloxifene
1. Hypersensitivity to Raloxifene
2. Pulmonary embolism
3. Retinal vein thrombosis
4. Deep vein thrombosis
5. Premenopausal women

Special Precautions while taking Raloxifene
1. Severe hepatic impairment
2. Superficial thrombophlebitis
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Raloxifene
1. Osteoporosis in postmenopausal women
Interactions for Raloxifene
Do not coadminister HRT / oestrogens / cholestyramine / clofibrate / indomethacin / naproxen / ibuprofen / diazepam.
Typical Dosage for Raloxifene
Adult: 60 mg / day
Schedule of Raloxifene
Storage Requirements for Raloxifene
Store at 15 - 30 degree Celsius. Keep out of the reach of children
Effects of Missed Dosage of Raloxifene
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Raloxifene
Give supportive measures and symptomatic treatment.

Home Delivery for Raloxifene in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including raloxifene.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for raloxifene and other medicines and health products. Home delivery services for raloxifene may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take raloxifene only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for raloxifene before they complete the sale. You can get this information while placing the order for raloxifene with the pharmacy.

Raloxifene is a generic medicine name and there are several brands available for it. Some of the brands for raloxifene might be better known than raloxifene itself. If the pharmacy that's willing to deliver medicines to your home doesn't have raloxifene in stock, you can ask for one of the branded alternatives for raloxifene.