Alfacalcidol Pharmacology


About Alfacalcidol
Nutritional supplement,Vitamin D derivative, Antihypoparathyroid, Antihypocalcemic.
Mechanism of Action of Alfacalcidol
Alfacalcidol is a prodrug of Vitamin D and is rapidly hydroxylated in the liver in to calcitriol. Vitamin D exerts it`s action by influencing calcium homoeostasis. It increases the intestinal absorption of calcium and phosphate. It binds to the cytoplasmic Vitamin D receptor and translocates to the nucleus and thus increases the synthesis of specific m RNA and regulates protein synthesis. It increases the synthesis of a carrier protein for calcium called "calbindin" or calcium binding protein. Activation of Vitamin D receptor enhances endocytotic capture of calcium and it`s transport across duodenal mucosal cells in a vesicular form. Vitamin D promotes resorption of calcium and phosphate from bone by enhancing recruitment and differentiation of osteoclast precursors in the bone remodeling units. It helps in bone mineralization.
Pharmacokinets of Alfacalcidol
Absorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form. It is stored in adipose tissue and liver. Metabolism: It is hydroxylated in to calcitriol in liver. Excretion: Excreted mainly through bile.

Onset of Action for Alfacalcidol
Duration of Action for Alfacalcidol
Half Life of Alfacalcidol
Side Effects of Alfacalcidol
9.Calcification of soft tissues (blood vessels, parenchymal organs including heart)
10.Renal stones
11.Growh retardation in children
Contra-indications of Alfacalcidol
2.Hypervitaminosis D
3.Hyperphosphataemia (except when occurring with hypoparathyroidism
Special Precautions while taking Alfacalcidol
1 Renal impairment
3.Renal stones
4.Coronary diseases.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Alfacalcidol
1.Rickets and Osteomalacia
2.Hypoparathyroidism with bone disease
3.Renal osteodystrophy
Interactions for Alfacalcidol
Digitallis preparations: Cardiac arrhythmias precipitated.
Thiazide Diuretics: Hypercalcaemic response enhanced.
Barbiturates & other enzyme inducing anticonvulsants: Reduce efficacy.
Minteral Oil: Prolonged use reduces efficacy.
Cholestyramine, Cholestipol, Sucralfate, Aluminium based Antacids: Reduced efficacy by decreasing absorption of alfacalcidol.
Magnesium based Antacids or Laxatives: Hypermagnesaemia in those on chronic renal dialysis.
Typical Dosage for Alfacalcidol
Starts with 1mcg daily. Adjusted based on patients response to 2mcg daily if required.
Children over 20kg: Starts with 1mcg daily. Adjusted based on patient`s response.
Children under 20kg: 0.5mcg daily or 0.05mcg/kg/day
Schedule of Alfacalcidol
Storage Requirements for Alfacalcidol
Store in a well closed container in a cool place. Protect from light and excess heat. Keep out of reach of children.
Effects of Missed Dosage of Alfacalcidol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Alfacalcidol
Provide supportive and symptomatic treatment. Stops the treatment and starting a low calcium diet. Increases the fluid intake and administer Loop diuretics like furosemide may be given with saline I.V. infusion to increase calcium excretion. Calcitonin may decrease hypercalcaemia.

Home Delivery for Alfacalcidol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including alfacalcidol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for alfacalcidol and other medicines and health products. Home delivery services for alfacalcidol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take alfacalcidol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for alfacalcidol before they complete the sale. You can get this information while placing the order for alfacalcidol with the pharmacy.

Alfacalcidol is a generic medicine name and there are several brands available for it. Some of the brands for alfacalcidol might be better known than alfacalcidol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have alfacalcidol in stock, you can ask for one of the branded alternatives for alfacalcidol.