Calcitriol Pharmacology


About Calcitriol
Mechanism of Action of Calcitriol
Calcitriol is a 1, 25-dihydroxycholecalciferol or a Vitamin D analogue. It increases the absorption of Calcium from intestine by forming a calcium binding protein. It reverses the signs of rickets and osteomalacia.
Pharmacokinets of Calcitriol
Absorption: It is readily absorbed after oral administration. Distribution: It is widely distributed in protein bound form. Metabolism: It undergoes metabolism in the liver and kidney. Excretion: It is excreted mainly in the faeces.
Onset of Action for Calcitriol
2 - 6 hours
Duration of Action for Calcitriol
3 - 5 days
Half Life of Calcitriol
3 - 8 hours
Side Effects of Calcitriol
1. Nausea
2. Vomiting
3. Constipation
4. Headache
5. Somnolence
6. Weakness
7. Hypertension
8. Bone and muscle pain
9. Pruritus
10. Weight loss
11. Polyuria
12. Metallic taste
13. Anorexia
14. Dry mouth
Contra-indications of Calcitriol
1. Hypercalcaemia
2. Metastatic calcification
3. Plasma phosphorus level greater than 6 mg/dl

Special Precautions while taking Calcitriol
1.Liver impairment
2.Renal impairment
3.Monitor plasma calcium and creatinine in patients receiving high doses
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Calcitriol
1.Management of Hypocalcaemia
2.Management of hypoparathyroidism and pseudohypoparathyroidism
Interactions for Calcitriol
Typical Dosage for Calcitriol
Management of hypocalcaemia:0.25mcg/day.Dosage can be increased by 0.25mcg/day at 1 - 2 month interval.Maintenance dose:0.25 - 1 mcg/ day.
Management of hypoparathyroidism and psedohypothyroidism:0.25mcg/day in the morning and dosage can be incresed at 2 - 4 week intervals.Maintenance dose: 0.5 - 2 mcg/day
Children:above 6 years:same as adult dose
Children 1 - 5 years: 0.25 - 0.75mcg/day
Schedule of Calcitriol
Storage Requirements for Calcitriol
Store in a well closed container.Protect from heat,light and moisture.Keep out of the reach of children.
Effects of Missed Dosage of Calcitriol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.
Effects of Overdose of Calcitriol
Give supportive mesures and symptomatic treatment.

Home Delivery for Calcitriol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including calcitriol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for calcitriol and other medicines and health products. Home delivery services for calcitriol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take calcitriol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for calcitriol before they complete the sale. You can get this information while placing the order for calcitriol with the pharmacy.

Calcitriol is a generic medicine name and there are several brands available for it. Some of the brands for calcitriol might be better known than calcitriol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have calcitriol in stock, you can ask for one of the branded alternatives for calcitriol.