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- Pharmacology For Ranitidine + Dicyclomine
Ranitidine + Dicyclomine Pharmacology
Ranitidine + Dicyclomine
About Ranitidine + DicyclomineN/AMechanism of Action of Ranitidine + DicyclomineN/APharmacokinets of Ranitidine + DicyclomineN/AOnset of Action for Ranitidine + DicyclomineN/ADuration of Action for Ranitidine + DicyclomineN/AHalf Life of Ranitidine + DicyclomineN/ASide Effects of Ranitidine + DicyclomineN/AContra-indications of Ranitidine + DicyclomineN/ASpecial Precautions while taking Ranitidine + DicyclomineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ranitidine + DicyclomineN/AInteractions for Ranitidine + DicyclomineN/ATypical Dosage for Ranitidine + DicyclomineN/ASchedule of Ranitidine + DicyclomineN/AStorage Requirements for Ranitidine + DicyclomineN/AEffects of Missed Dosage of Ranitidine + DicyclomineN/AEffects of Overdose of Ranitidine + DicyclomineN/ARanitidine
About RanitidineA histamine H2-receptor antagonist, Furan derivative, Anti-secretory G.I agent,Anti ulcer.Mechanism of Action of RanitidineRanitidine is a H2 (Histamine) receptor antagonist. Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP. This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane. Ranitidine reversibly competes with Histamine for binding to H2 receptors on the parietal cells and predominantly inhibits basal acid secretion.
Anaesthetic adjuncts: It is used in patients undergoing prolonged operations, caesarian section,obese patients those are at increased risk of gastric regurgitation and aspiration pneumonia. It raises pH of gastric juice and also reduces its volume and thus chances of regurgitation. It is now routinely used before prolonged surgery.
Pharmacokinets of RanitidineAbsorption: Ranitidine is 50 % absorbed after oral administration. Distribution: Distributed mainly to body tissues in unbound form. Metabolism: Ranitidine undergoes metabolism in the liver. Excretion: It is excreted mainly in urine and in the faeces.Onset of Action for Ranitidine60 minutesDuration of Action for Ranitidine13hoursHalf Life of Ranitidine1.6- 2.4 hoursSide Effects of Ranitidine1. Headache
2. Dizziness
3. Constipation
4. Vertigo
5. Confusion
6. Rash
7. Blurred vision
8. Thrombocytopenia
9. Leukopenia
Contra-indications of Ranitidine1. Hypersensitivity to RanitidineSpecial Precautions while taking Ranitidine1. Hepatic impairment
2. Renal impairment
3. Acute Porphyria
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Ranitidine1. Duodenal ulcer
2. Benign gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux
5. Acid indigestion
6. Heart burn
7. Sour stomach
8. Stress ulcers
9. Oesophagitis
10.Preanaesthetic medication
Interactions for RanitidineAntacids: Ranitidine absorption may be decreased.
Diazepam: Efficacy of diazepam decreased.
Procainamide: Renal clearance of procainamide decreased.
Sulfonylureas: Hypoglycemic effects of glipizide enhanced.
Theophyllines: Increased efficacy of theophyllines with possible toxicity.
Warfarin: Increased hypoprothrombinemic effects.
Lab tests: False positive tests for urine proteins with multistix may occur.Typical Dosage for RanitidineAdult: 300mg / day
Duodenal ulcer, benign gastric ulcer: 300 mg /day as single dose at bed time or in 2 divided dose (morning and bed time) for minimum of 4 weeks.
Maintenance dose: 150 mg / day at bed time.
Zollinger- Ellison syndrome: 300 - 450 mg / day in 2 - 3 divided doses; dose can be increased if necessary to a maximum up to 6g / day .
Gastroesophageal reflux: 300 mg / day as single dose at bed time or in 2 divided doses (morning and bed time) for maximum 2 months. In severe conditions dose can be increased to 600 mg / day in 4 divided doses for 3 months
Acid indigestion, Heart burn, Sour stomach: Dose: 75 mg once daily to a maximum up to 150 mg / day.
Oesophagitis: 150 mg/ day.
Dyspepsia: 75 - 300 mg / day depending on the severity of disease.
PAM: 150mg given night and in the morning before surgical procedures.
Children:
Duodenal ulcer, benign gastric ulcer: 4 - 8 mg / kg body weight / day in 2 divided doses.
Maximum dose: 300 mg / day
Schedule of RanitidineHStorage Requirements for RanitidineStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of RanitidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RanitidineGive supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis and or by gastric lavage. Activated charcoal is given to reduce the absorption of the drug. Haemodialysis can be done if necessary.Dicyclomine
About DicyclomineAnticholinergic ,Antimuscarinic, Antispasmodic and in urinary incontinence.Mechanism of Action of DicyclomineDicyclomine is an anticholinergic drug. It exerts its action by inhibiting muscarinic (((cholinergic))) receptors on smooth muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles of gastrointestinal tract and genitourinary tract and reduces the painful spasm and cramp. It inhibits gastrointestinal propulsive motility and reduces gastric acid secretion. It also has a direct relaxant effect on smooth muscle. It readily crosses the blood brain barrier and produces CNS effects.Pharmacokinets of DicyclomineAbsorption: About 70 % of the drug is absorbed after oral administration.
Distribution: It is extensively distributed in tissue mainly in protein bound (((99%))) form. It readily crosses blood brain barrier.
Metabolism: Dicyclomine undergoes hepatic metabolism
Excretion: It is excreted mainly in the urine and small amount in the faeces.
Onset of Action for Dicyclomine1-2 hours.Duration of Action for Dicyclomine4-6 hours.Half Life of Dicyclomine1.8 hours (((initial phase))). 9 - 10 hours (((secondary phase)))Side Effects of Dicyclomine1.Constipation
2.Dry mouth
3.Nausea
4.Vomiting
5.Abdominal discomfort
6.Headache
7.Dizziness
8.Confusion
9.Palpitations
10.Tachycardia
11.Increased intraocular pressure
12.Mydriasis
13.Urine retention
14.Urinary hesitancy
15.Decreased sweating
Contra-indications of Dicyclomine1.Hypersensitivity to Dicyclomine and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
4.Obstructive uropathy
5.Reflux oesophagitis
6.Severe ulcerative colitis
7.Myasthenia gravis
8.Unstable cardiovascular status in acute haemorrhage
Special Precautions while taking Dicyclomine1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Prostatic hypertrophy
5.Hiatus hernia associated
6.Hyperthyroidism
7.Autonomic neuropathy
8.Ulcerative colitis
9.Arrhythmia
10.Hypertension
11.Coronary artery disease
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicatedChildren Related InformationUse with caution.
NEONATES: contraindicatedIndications for Dicyclomine1. Irritable bowel syndrome
2.Colicky pain
Interactions for DicyclomineN/ATypical Dosage for DicyclomineAdult:
Oral: 80 mg / day in 4 divided doses 30 - 60 minutes before meals. Depending on the patient`s response dose can be increased to 160 mg / day in 4 divided doses after 1 week.
Children:
Infant colic: 5 - 10 mg every 6 - 8 hours, 15 minutes before each feed; dose is depending on the patient`s response and age.
Schedule of DicyclomineHStorage Requirements for DicyclomineStore at 15 - 30 degree C in a tightly closed container. Protect from light.Keep out of the reach of children
Effects of Missed Dosage of DicyclomineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DicyclomineGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Physostigmine is given to block the overdose symptoms of Dicyclomine.Home Delivery for Ranitidine + Dicyclomine in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ranitidine + dicyclomine and other medicines and health products. Home delivery services for ranitidine + dicyclomine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Ranitidine + Dicyclomine is a generic medicine name and there are several brands available for it. Some of the brands for ranitidine + dicyclomine might be better known than ranitidine + dicyclomine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ranitidine + dicyclomine in stock, you can ask for one of the branded alternatives for ranitidine + dicyclomine.
