Lansoprazole Pharmacology


About Lansoprazole
A proton pump inhibitor, Benzimidazole derivative, Anti ulcer.
Mechanism of Action of Lansoprazole
Lansoprazole is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Lansoprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Lansoprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion.
Pharmacokinets of Lansoprazole
Absorption: Lansoprazole is well absorbed after oral administration.Distribution: It is widely distributed in the body in protein bound form.Metabolism: Lansoprazole is extensively metabolised in the liver.Excretion: It is excreted mainly in the faeces and small amount in urine.
Onset of Action for Lansoprazole
1- 2 hours
Duration of Action for Lansoprazole

1 day

Half Life of Lansoprazole
30- 90 minutes

Side Effects of Lansoprazole
4.Abdominal pain
10. Rash

Contra-indications of Lansoprazole
Hypersensitivity to Lansoprazole

Special Precautions while taking Lansoprazole
1.Hepatic impairment
2.Monitor gastric malignancy
3.Avoid prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution
Children Related Information

NEONATES: Contraindicated
Indications for Lansoprazole
1. Duodenal ulcer
2. Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
5. Oesophagitis
6. Acid related dyspepsia
7. NSAID associated ulceration

Interactions for Lansoprazole
Antacids: Bio-availability of lansoprazole reduced.
Oral contraceptives, Phenytoin, Theophylline and Warfarin: Caution should be exercised while using these drugs which are metabolised by the liver since lansoprazole is a weak inducer of P450 cytochrome.
Typical Dosage for Lansoprazole
Adult: 15 - 30 mg / day to be taken before meals.
Duodenal ulcer: 15 mg / day before meals for 1 month.
Gastric ulcer: 30 mg / day for 2 months.
Zollinger- Ellison syndrome: 60 mg / day increase the dose to 180 mg/ day in 2 divided doses if needed.
Gastroesophageal reflux disease: 15 mg / day for 2 months.
Oesophagitis: 30 mg / day before meals for 2 months continue the treatment for 2 more months if needed.
Acid related dyspepsia: 15 - 30 mg / day before breakfast for 1 month.
NSAID associated ulceration: 15 - 30 mg / day for 1 - 2 months.

Children: not recommended
Schedule of Lansoprazole
Storage Requirements for Lansoprazole
Store at 15 - 30 degree C in a tightly closed container. Protect from light.
Effects of Missed Dosage of Lansoprazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Lansoprazole
Give supportive measures and symptomatic treatment.

Home Delivery for Lansoprazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lansoprazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lansoprazole and other medicines and health products. Home delivery services for lansoprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lansoprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lansoprazole before they complete the sale. You can get this information while placing the order for lansoprazole with the pharmacy.

Lansoprazole is a generic medicine name and there are several brands available for it. Some of the brands for lansoprazole might be better known than lansoprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lansoprazole in stock, you can ask for one of the branded alternatives for lansoprazole.