Omeprazole Pharmacology


About Omeprazole
Proton Pump Inhibitor, Substituted Benzimidazole, Anti-secretory,antiulcer.
Mechanism of Action of Omeprazole
Omeprazole is a proton pump inhibitor and it is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Omeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Omeprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion.
Pharmacokinets of Omeprazole
Absorption: Omeprazole is well absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Omeprazole is extensively metabolised in the liver.
Excretion: It is excreted mainly in the faeces and small amount in urine.
Onset of Action for Omeprazole
2- 5 hours
Duration of Action for Omeprazole
1 day
Half Life of Omeprazole
30 - 90 minutes
Side Effects of Omeprazole
1. Diarrhoea
2. Nausea
3. Vomiting
4. Abdominal pain
5. Constipation
6. Flatulence
7. Headache
8. Dry mouth
9. Dizziness
10. Myalgia
11. Rash
Contra-indications of Omeprazole
1. Hypersensitivity to Omeprazole
Special Precautions while taking Omeprazole
1. Hepatic impairment
2. Monitor gastric malignancy
3. Avoid prolonged use
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Omeprazole
1. Duodenal ulcer
2. Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
5. Oesophagitis
6. Acid related dyspepsia
7. NSAID associated ulceration
8. Prophylaxis of acid aspiration during anesthesia
Interactions for Omeprazole
Diazepam: Half life of diazepam is increased.
Phenytoin: Increased plasma concentration of phenytoin.
Oral Anticoagulants: May prolong the elimination of warfarin.
Cyclosporine, Disulfiram: Omeprazole interferes with the metabolism of these drugs.
Ketaconazole, Ampicillin esters, Iron Salts: Omeprazole may interfere with the absorption of these drugs where gastric pH is a determinant of their bio-availability.
Typical Dosage for Omeprazole
Oral :
Adult: 10 - 20 mg / day to be taken before meals.
Duodenal ulcer: 20 mg / day to be taken 30 minutes before meals for 1-2 months.
Gastric ulcer: 20 mg / day for 1-2 months.In severe cases dose can be increased to 40 mg / day. Maintenance dose: 10 - 20 mg / day.
Zollinger- Ellison syndrome: 60 mg / day increase the dose maximum up to 360 mg/ day in 3 divided doses if needed.
Gastroesophageal reflux disease, oesophagitis: 20 mg / day for 1-2 months.
Acid related dyspepsia: 10 - 20 mg / day for 1 month.
NSAID associated ulceration: 20mg / day for 1 month.
Prophylaxis of acid aspiration during anesthesia: 40 mg in the evening before the surgery and the same dose 2 - 6 hours before the procedure.
Children: Not recommended
Schedule of Omeprazole
Storage Requirements for Omeprazole
Store at 15 - 30 degree C in a tightly closed container. Protect from light.
Effects of Missed Dosage of Omeprazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Omeprazole
Give supportive measures and symptomatic treatment.

Home Delivery for Omeprazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including omeprazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for omeprazole and other medicines and health products. Home delivery services for omeprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take omeprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for omeprazole before they complete the sale. You can get this information while placing the order for omeprazole with the pharmacy.

Omeprazole is a generic medicine name and there are several brands available for it. Some of the brands for omeprazole might be better known than omeprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have omeprazole in stock, you can ask for one of the branded alternatives for omeprazole.