Esomeprazole Pharmacology

Esomeprazole

About Esomeprazole

A proton pump inhibitor, Substituted Benzimidazole, Antiulcer, antisecretory drug.

Mechanism of Action of Esomeprazole

Esomeprazole is the S enantiomer of Omeprazole and is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Esomeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Esomeprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion. As compared to Omeprazole, Esomeprazole produces better control of intragastric acidity in Gastroesophageal reflux diseases. It is as effective as Omeprazole in other disease condition.

Pharmacokinets of Esomeprazole

Absorption: Esomeprazole is well absorbed after oral administration. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Esomeprazole is extensively metabolised in the liver. Excretion: It is excreted mainly in the urine and small amount in faeces.

Onset of Action for Esomeprazole

Rapid

Duration of Action for Esomeprazole

Prolonged

Half Life of Esomeprazole

60- 90 minutes

Side Effects of Esomeprazole

1.Diarrhoea
2.Nausea
3.Abdominal pain
4.Constipation
5.Headache
6.Flatulence
7.Dry mouth

Contra-indications of Esomeprazole

1.Gastric ulcer
2.Gastroesophageal reflux disease
3.Oesophagitis
4.NSAID associated ulceration
5.Duodenal ulcer related to H. pylori infection

Special Precautions while taking Esomeprazole

1.Hepatic impairment
2.Monitor gastric malignancy

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution
NEONATES: contraindicated

Indications for Esomeprazole

1.Gastric ulcer
2.Gastroesophageal reflux disease
3.Oesophagitis
4.NSAID associated ulceration
5.Duodenal ulcer related to H. pylori infection

Interactions for Esomeprazole

Esomeprazole may potentially interfere with CYP2Cl9, the major esomeprazole metabolizing enzyme.
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts and digoxin). Esomeprazole does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxycillin.

Typical Dosage for Esomeprazole

Gastro-oesophageal Reflux Disease (GORD): Healing of erosive oesophagitis: 20mg or 40mg once daily for 4 to 8 weeks.
Maintenance of healing of erosive esophagitis: 20mg once daily.
Symptomatic gastroesophageal reflux disease: 20mg once daily for 4 weeks.
H. pylori eradication to reduce the risk of duodenal ulcer recurrence
Esomeprazole: 40mg, once daily for 10 days along with Amoxycillin and Clarithromycin

Schedule of Esomeprazole

Storage Requirements for Esomeprazole

Store at 15 - 30 degree C in a tightly closed container. Protect from light.

Effects of Missed Dosage of Esomeprazole

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Esomeprazole

Give supportive measures and symptomatic treatment.

Home Delivery for Esomeprazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including esomeprazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for esomeprazole and other medicines and health products. Home delivery services for esomeprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take esomeprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for esomeprazole before they complete the sale. You can get this information while placing the order for esomeprazole with the pharmacy.

Esomeprazole is a generic medicine name and there are several brands available for it. Some of the brands for esomeprazole might be better known than esomeprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have esomeprazole in stock, you can ask for one of the branded alternatives for esomeprazole.