Rabeprazole Pharmacology


About Rabeprazole
Benzimidazole derivative, Proton Pump Inhibitor, Antiulcer.
Mechanism of Action of Rabeprazole
Rabeprazole sodium is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Rabeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Rabeprazole sodium irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Rabeprazole produces fastest acid suppression and helps in mucin synthesis.
Pharmacokinets of Rabeprazole
Absorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes first pass metabolism. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Rabeprazole sodium is extensively metabolised in the liver. Excretion: It is excreted mainly in the urine and small amount in faeces.
Onset of Action for Rabeprazole
Duration of Action for Rabeprazole
1 day
Half Life of Rabeprazole
1 - 2 hours
Side Effects of Rabeprazole
1. Diarrhoea
2. Nausea
3. Headache
4. Vomiting
5. Abdominal pain
6. Dizziness
7. Flatulence
8. Constipation
9. Dyspepsia
10. Flu like syndrome
11. Insomnia
12. Back pain
13. Cough
14. Rhinitis
15. Pharyngitis
16. Rash

Contra-indications of Rabeprazole
1. Hypersensitivity to Rabeprazole sodium
Special Precautions while taking Rabeprazole
1. Hepatic impairment
2. Monitor gastric malignancy

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Rabeprazole
1. Active Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Erosive Gastroesophageal reflux disease
Interactions for Rabeprazole
Ketoconazole : Coadministration of rabeprazole sodium results in a 33% decrease in ketoconazole levels.
Digoxin : Increase in trough digoxin levels in normal subjects.
Typical Dosage for Rabeprazole
Adult: 10 - 20 mg / day drug to be taken before breakfast.
Duodenal ulcer: 20 mg / day in the morning for 1 month if needed dose can be continuing for 1more month.
Benign Gastric ulcer: 20 mg / day in the morning for 6 weeks if needed dose can be continuing for 6 more weeks.
Zollinger- Ellison syndrome: Initial dose: 60 mg / day if needed increase the dose up to 120 mg / day in 2 divided doses.
Erosive Gastroesophageal reflux disease: 20mg / day for 1-2 months.
Gastroesophageal reflux disease long term management: 10-20 mg once daily before breakfast for 1 year

Children: not recommended
Schedule of Rabeprazole
Storage Requirements for Rabeprazole
Store at 15 - 30 degree C in a tightly closed container. Protect from light.
Effects of Missed Dosage of Rabeprazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Rabeprazole
Give supportive measures and symptomatic treatment.

Home Delivery for Rabeprazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including rabeprazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rabeprazole and other medicines and health products. Home delivery services for rabeprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take rabeprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for rabeprazole before they complete the sale. You can get this information while placing the order for rabeprazole with the pharmacy.

Rabeprazole is a generic medicine name and there are several brands available for it. Some of the brands for rabeprazole might be better known than rabeprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rabeprazole in stock, you can ask for one of the branded alternatives for rabeprazole.