Pantoprazole Pharmacology


About Pantoprazole
A proton pump inhibitor, Benzimidazole derivative, Anti ulcer.
Mechanism of Action of Pantoprazole
Pantoprazole is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Pantoprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Pantoprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Pantoprazole is more acid stable and its activity is lowered in higher pH. It is the only proton pump inhibitor which is available as parenteral form.

Pharmacokinets of Pantoprazole
Absorption: Pantoprazole is well absorbed after oral administration. Its bioavailability is about 77% since it`s undergoes first pass metabolism.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Pantoprazole is extensively metabolised in the liver.
Excretion: It is excreted mainly in the urine and small amount in faeces.
Onset of Action for Pantoprazole
2-4 hours
Duration of Action for Pantoprazole
1 day
Half Life of Pantoprazole
60 minutes
Side Effects of Pantoprazole
1. Diarrhoea
2. Nausea
3. Vomiting
4. Headache
5. Flatulence
6. Abdominal pain
7. Pruritis
8. Dizziness
9. Rash

Contra-indications of Pantoprazole
1. Hypersensitivity to Pantoprazole
Special Precautions while taking Pantoprazole
1. Hepatic impairment
2. Monitor liver function
3. Avoid prolonged use
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Below 12 years : Contraindicated
Indications for Pantoprazole
1. Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
Interactions for Pantoprazole
Phenazone (antipyrine), diazepam, digoxin, theophylline, carbamazepine, diclofenac, phenprocoumon, phenytoin, warfarin, nifedipine, caffeine, metoprolol or ethanol : No clinically relevant interaction at therapeutic doses.
Oral contraceptives : Does not appear to compromise hormonal contraceptive efficacy as no interaction with a low dose combined oral contraceptive has been seen.
Typical Dosage for Pantoprazole
Oral :
Adult: 20-40mg / day before breakfast.
Duodenal ulcer: 40mg / day to be taken before breakfast for 2 - 4 weeks.
Benign Gastric ulcer: 40mg / day to be taken before breakfast for 1 - 2months.
Zollinger- Ellison syndrome: 80 mg / day in 2 divided doses increase the dose to 240 mg/ day if needed.
Gastroesophageal reflux disease: 20 - 40 mg / day to be taken before breakfast for 1 month and continue the treatment for 1 more month if needed.
Parenteral: 40 mg once daily as IV injection over 15 minutes.
Children below 12 years : Not recommended
Schedule of Pantoprazole
Storage Requirements for Pantoprazole
Store at 15 - 30 degree C in a tightly closed container. Protect from light.
Effects of Missed Dosage of Pantoprazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Pantoprazole
Give supportive measures and symptomatic treatment.

Home Delivery for Pantoprazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pantoprazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pantoprazole and other medicines and health products. Home delivery services for pantoprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take pantoprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pantoprazole before they complete the sale. You can get this information while placing the order for pantoprazole with the pharmacy.

Pantoprazole is a generic medicine name and there are several brands available for it. Some of the brands for pantoprazole might be better known than pantoprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pantoprazole in stock, you can ask for one of the branded alternatives for pantoprazole.