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- Pharmacology For Lansoprazole + Domperidone
Lansoprazole + Domperidone Pharmacology
Lansoprazole + DomperidoneAbout Lansoprazole + DomperidoneN/AMechanism of Action of Lansoprazole + DomperidoneN/APharmacokinets of Lansoprazole + DomperidoneN/AOnset of Action for Lansoprazole + DomperidoneN/ADuration of Action for Lansoprazole + DomperidoneN/AHalf Life of Lansoprazole + DomperidoneN/ASide Effects of Lansoprazole + DomperidoneN/AContra-indications of Lansoprazole + DomperidoneN/ASpecial Precautions while taking Lansoprazole + DomperidoneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Lansoprazole + DomperidoneN/AInteractions for Lansoprazole + DomperidoneN/ATypical Dosage for Lansoprazole + DomperidoneN/ASchedule of Lansoprazole + DomperidoneN/AStorage Requirements for Lansoprazole + DomperidoneN/AEffects of Missed Dosage of Lansoprazole + DomperidoneN/AEffects of Overdose of Lansoprazole + DomperidoneN/A
LansoprazoleAbout LansoprazoleA proton pump inhibitor, Benzimidazole derivative, Anti ulcer.Mechanism of Action of LansoprazoleLansoprazole is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Lansoprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Lansoprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion.
Pharmacokinets of LansoprazoleAbsorption: Lansoprazole is well absorbed after oral administration.Distribution: It is widely distributed in the body in protein bound form.Metabolism: Lansoprazole is extensively metabolised in the liver.Excretion: It is excreted mainly in the faeces and small amount in urine.
Onset of Action for Lansoprazole1- 2 hoursDuration of Action for Lansoprazole
Half Life of Lansoprazole30- 90 minutes
Side Effects of Lansoprazole1.Diarrhoea
Contra-indications of LansoprazoleHypersensitivity to Lansoprazole
Special Precautions while taking Lansoprazole1.Hepatic impairment
2.Monitor gastric malignancy
3.Avoid prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with caution.Breast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
Indications for Lansoprazole1. Duodenal ulcer
2. Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
6. Acid related dyspepsia
7. NSAID associated ulceration
Interactions for LansoprazoleAntacids: Bio-availability of lansoprazole reduced.
Oral contraceptives, Phenytoin, Theophylline and Warfarin: Caution should be exercised while using these drugs which are metabolised by the liver since lansoprazole is a weak inducer of P450 cytochrome.Typical Dosage for LansoprazoleAdult: 15 - 30 mg / day to be taken before meals.
Duodenal ulcer: 15 mg / day before meals for 1 month.
Gastric ulcer: 30 mg / day for 2 months.
Zollinger- Ellison syndrome: 60 mg / day increase the dose to 180 mg/ day in 2 divided doses if needed.
Gastroesophageal reflux disease: 15 mg / day for 2 months.
Oesophagitis: 30 mg / day before meals for 2 months continue the treatment for 2 more months if needed.
Acid related dyspepsia: 15 - 30 mg / day before breakfast for 1 month.
NSAID associated ulceration: 15 - 30 mg / day for 1 - 2 months.
Children: not recommended
Schedule of LansoprazoleHStorage Requirements for LansoprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of LansoprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of LansoprazoleGive supportive measures and symptomatic treatment.
DomperidoneAbout DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
Special Precautions while taking Domperidone1.Hepatic impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents.
Home Delivery for Lansoprazole + Domperidone in Your City
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Lansoprazole + Domperidone is a generic medicine name and there are several brands available for it. Some of the brands for lansoprazole + domperidone might be better known than lansoprazole + domperidone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lansoprazole + domperidone in stock, you can ask for one of the branded alternatives for lansoprazole + domperidone.