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- Pharmacology For Rabeprazole + Domperidone
Rabeprazole + Domperidone Pharmacology
Rabeprazole + DomperidoneAbout Rabeprazole + DomperidoneN/AMechanism of Action of Rabeprazole + DomperidoneN/APharmacokinets of Rabeprazole + DomperidoneN/AOnset of Action for Rabeprazole + DomperidoneN/ADuration of Action for Rabeprazole + DomperidoneN/AHalf Life of Rabeprazole + DomperidoneN/ASide Effects of Rabeprazole + DomperidoneN/AContra-indications of Rabeprazole + DomperidoneN/ASpecial Precautions while taking Rabeprazole + DomperidoneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Rabeprazole + DomperidoneN/AInteractions for Rabeprazole + DomperidoneN/ATypical Dosage for Rabeprazole + DomperidoneN/ASchedule of Rabeprazole + DomperidoneN/AStorage Requirements for Rabeprazole + DomperidoneN/AEffects of Missed Dosage of Rabeprazole + DomperidoneN/AEffects of Overdose of Rabeprazole + DomperidoneN/A
RabeprazoleAbout RabeprazoleBenzimidazole derivative, Proton Pump Inhibitor, Antiulcer.Mechanism of Action of RabeprazoleRabeprazole sodium is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Rabeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Rabeprazole sodium irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Rabeprazole produces fastest acid suppression and helps in mucin synthesis.Pharmacokinets of RabeprazoleAbsorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes first pass metabolism. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Rabeprazole sodium is extensively metabolised in the liver. Excretion: It is excreted mainly in the urine and small amount in faeces.Onset of Action for Rabeprazole1hourDuration of Action for Rabeprazole1 dayHalf Life of Rabeprazole1 - 2 hoursSide Effects of Rabeprazole1. Diarrhoea
5. Abdominal pain
10. Flu like syndrome
12. Back pain
Contra-indications of Rabeprazole1. Hypersensitivity to Rabeprazole sodiumSpecial Precautions while taking Rabeprazole1. Hepatic impairment
2. Monitor gastric malignancy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: ContraindicatedIndications for Rabeprazole1. Active Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Erosive Gastroesophageal reflux disease
Interactions for RabeprazoleKetoconazole : Coadministration of rabeprazole sodium results in a 33% decrease in ketoconazole levels.
Digoxin : Increase in trough digoxin levels in normal subjects.
Typical Dosage for RabeprazoleOral
Adult: 10 - 20 mg / day drug to be taken before breakfast.
Duodenal ulcer: 20 mg / day in the morning for 1 month if needed dose can be continuing for 1more month.
Benign Gastric ulcer: 20 mg / day in the morning for 6 weeks if needed dose can be continuing for 6 more weeks.
Zollinger- Ellison syndrome: Initial dose: 60 mg / day if needed increase the dose up to 120 mg / day in 2 divided doses.
Erosive Gastroesophageal reflux disease: 20mg / day for 1-2 months.
Gastroesophageal reflux disease long term management: 10-20 mg once daily before breakfast for 1 year
Children: not recommended
Schedule of RabeprazoleHStorage Requirements for RabeprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of RabeprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RabeprazoleGive supportive measures and symptomatic treatment.
DomperidoneAbout DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
Special Precautions while taking Domperidone1.Hepatic impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents.
Home Delivery for Rabeprazole + Domperidone in Your City
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Rabeprazole + Domperidone is a generic medicine name and there are several brands available for it. Some of the brands for rabeprazole + domperidone might be better known than rabeprazole + domperidone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rabeprazole + domperidone in stock, you can ask for one of the branded alternatives for rabeprazole + domperidone.