Misoprostol Pharmacology


About Misoprostol
A synthetic prostaglandin E1 (PGE1) analogue, Anti ulcer(antisecretory and protective),Abortifacient.
Mechanism of Action of Misoprostol
Misoprostol is a synthetic Prostaglandin E1 analog. It binds to the EP3 receptor on the basolateral membrane of the parietal cells and stimulates the inhibitory G protein (Gi) receptors. This will leads to decrease in intracellular cyclic AMP level and inhibits proton pump (H+K+ATPase) which exchange the extracellular K+ for intracellular H+ ion. By inhibiting the proton pump Misoprostol decreases gastric acid secretion. Misoprostol also binds to the EP3 receptor on the superficial epithelial cells of the lumen and stimulates the mucin and bicarbonate secretion and decreases nocturnal, basal and stimulated gastric acid secretion.
Pharmacokinets of Misoprostol
Absorption: Misoprostol is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: Misoprostol is rapidly undergoes de-esterification and form active metabolite Misoprostol acid. Excretion: Metabolite is excreted mainly in the urine and small amount in the faeces.
Onset of Action for Misoprostol
30 minutes
Duration of Action for Misoprostol
3 hours
Half Life of Misoprostol
20 - 40 minutes
Side Effects of Misoprostol
4.Abdominal pain
Contra-indications of Misoprostol
1.Hypersensitivity to Misoprostol and other Prostaglandins
Special Precautions while taking Misoprostol
1.Cardiovascular disease
2.Cerebrovascular disease
3.Renal impairment

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: contraindicated
Indications for Misoprostol
1.NSAID induced ulcer
2.Duodenal ulcer
3.Gastric ulcer
Interactions for Misoprostol
Analgesics: Increased risk of CNS toxicity with phenylbutazone.
Typical Dosage for Misoprostol
Adult: NSAID induced ulcer: 200mcg 4 times daily with meals and at bed time for atleast1 month and up to 2 month.
Duodenal ulcer, Gastric ulcer: 400 - 800 mcg/ day in 4 divided doses with meals and at bed time for 1 - 2 month.
Children: not recommended
Schedule of Misoprostol
Storage Requirements for Misoprostol
Store at 15 - 30 degree C in a tightly closed container. Protect from light.
Effects of Missed Dosage of Misoprostol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Misoprostol
Give supportive measures and symptomatic treatment.

Home Delivery for Misoprostol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including misoprostol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for misoprostol and other medicines and health products. Home delivery services for misoprostol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take misoprostol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for misoprostol before they complete the sale. You can get this information while placing the order for misoprostol with the pharmacy.

Misoprostol is a generic medicine name and there are several brands available for it. Some of the brands for misoprostol might be better known than misoprostol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have misoprostol in stock, you can ask for one of the branded alternatives for misoprostol.