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- Pharmacology For Amoxycillin + Clarithromycin + Omeprazole
Amoxycillin + Clarithromycin + Omeprazole Pharmacology
Amoxycillin + Clarithromycin + Omeprazole
About Amoxycillin + Clarithromycin + OmeprazoleN/AMechanism of Action of Amoxycillin + Clarithromycin + OmeprazoleN/APharmacokinets of Amoxycillin + Clarithromycin + OmeprazoleN/AOnset of Action for Amoxycillin + Clarithromycin + OmeprazoleN/ADuration of Action for Amoxycillin + Clarithromycin + OmeprazoleN/AHalf Life of Amoxycillin + Clarithromycin + OmeprazoleN/ASide Effects of Amoxycillin + Clarithromycin + OmeprazoleN/AContra-indications of Amoxycillin + Clarithromycin + OmeprazoleN/ASpecial Precautions while taking Amoxycillin + Clarithromycin + OmeprazoleN/APregnancy Related InformationContraindicated; Clarithromycin and Omeprazole are contraindicated in pregnancy so the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; Clarithromycin and Omeprazole are contraindicated in breast feeding so the combination generic cannot be used in lactating mother.Children Related InformationN/AIndications for Amoxycillin + Clarithromycin + OmeprazoleH. pylori infection.
The combination of these three drugs works better to kill the bacteria than the antibiotics alone. It is a very effective combination to eradicate H. pylori infection in ulcer patients.
Interactions for Amoxycillin + Clarithromycin + OmeprazoleN/ATypical Dosage for Amoxycillin + Clarithromycin + OmeprazoleAdult: 1 kit 2 times daily for 1 week
Each kit contains Amoxycillin 750 mg + Clarithromycin 250 mg + Omeprazole 20 mg
Schedule of Amoxycillin + Clarithromycin + OmeprazoleN/AStorage Requirements for Amoxycillin + Clarithromycin + OmeprazoleN/AEffects of Missed Dosage of Amoxycillin + Clarithromycin + OmeprazoleN/AEffects of Overdose of Amoxycillin + Clarithromycin + OmeprazoleN/AAmoxycillin
About AmoxycillinSemisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative.Mechanism of Action of AmoxycillinAmoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once.Pharmacokinets of AmoxycillinAbsorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted
in breast milk
Onset of Action for Amoxycillin60 -120 minutesDuration of Action for Amoxycillin6-8 hoursHalf Life of Amoxycillin60 minutesSide Effects of Amoxycillin1.Aaphylaxis
2. Vomiting
3.Diarrhoea
4 Nausea
5.Rash
6.Urticaria
7.Thrombocytopenia
8.Nephritis
9.Seizure
10.Super infections.
Contra-indications of AmoxycillinHypersensitivity to Amoxicillin and other Penicillins.Special Precautions while taking Amoxycillin1.Mononucleosis
2.Lymphatic leukaemia
3.HIV infections
4.Hepatic impairment
5.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Amoxycillin1Urinary tract infections
2.Gonorrhoea
3 Meningitis
4.SABE
5.Respiratory tract infections
6.Septicemia
7.Soft tissue infections
8.Otitis media
9.Sinusitis
10.Tetanus
11.Biliarytract infections
12.Bronchitis
13.Salmonellosis
14.Typhoid
15.Gastroenteritis
16.Chlamydia infection
17.Paratyphoid fever
18.Dental infections
Interactions for AmoxycillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Erythromycin, Tetracycline: Reduce efficacy.Typical Dosage for AmoxycillinADULT: 250 - 500 mg three to four times daily.
In severe infections dose can be increased to 3 - 6 g daily depending on the severity of infection.
CHILDREN:125 - 250 mg three to four times a day depending on the severity of infection.
Schedule of AmoxycillinHStorage Requirements for AmoxycillinIt should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of AmoxycillinTake the dose as soon as noticed and if it is the time to the next dose then skip the missed doseEffects of Overdose of AmoxycillinGive supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed.
Clarithromycin
About ClarithromycinIt is a new macrolide antimicrobial drug.It is the most effective macrolide against Haemophilus influenzae, chlamydia trachomaitis and chlamydia pneumoniae.Mechanism of Action of ClarithromycinClarithromycin is a member of macrolide antibiotic.It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie:they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl tRNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Pharmacokinets of ClarithromycinAbsorption: Clarithromycin is completely absorbed after oral administration. Distribution: It is widely distributed in the body .Metabolism: It is metabolized in to active and inactive compound .Excretion: It is excreted through urine.Onset of Action for Clarithromycin0.5 - 1 hourDuration of Action for Clarithromycin8 - 12 hourHalf Life of ClarithromycinN/ASide Effects of Clarithromycin1.Nausea
2.Vomiting
3.Diarrhoea
4.Epigastric pain
5.Abnormal taste
6.Headache
7.Dizziness
8.Elevated hepatic enzyme
9.Pseudomembranous colitisContra-indications of Clarithromycin1.Hypersensitivity to clarithromycin and other macrolide
2.Liver diseaseSpecial Precautions while taking Clarithromycin1.Renal impairment
2.Hepatic dysfunction
3.cardiac abnormalitiesPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Clarithromycin1.Tonsilitis
2.Pharyngitis
3.Pneumonia
4.Skin and soft tissue infections
5.Bronchitis
6.Otitis media
7.Prophylaxis of MAC
8.Leprosy
9.Acne
10.NocardiosisInteractions for ClarithromycinTerfenadine: Concomitant use may cause cardiac arrhythmia.
Carbamazepine & Theophylline: Concurrent use causes increase in serum levels of these drugs.
Zidovudine: In HIV infected patients steady state Zidovudine levels decreased.
Increased efficacy of the following drugs which are metabolised by the cytochrome P450 system: Digoxin, Warfarin, Ergot alkaloids, Triazolam, Midazolam and Cyclosporine.Typical Dosage for ClarithromycinAdult: 250 - 500 mg twice daily for 1 - 2 week
Children: 7.5 mg/kg body weight two times daily for 1 - 2 week
Schedule of ClarithromycinHStorage Requirements for ClarithromycinStore in a cool dark place. Keep away from heat and moisture.Effects of Missed Dosage of ClarithromycinTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of ClarithromycinGive supportive measures and treatmentOmeprazole
About OmeprazoleProton Pump Inhibitor, Substituted Benzimidazole, Anti-secretory,antiulcer.Mechanism of Action of OmeprazoleOmeprazole is a proton pump inhibitor and it is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Omeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Omeprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion.
Pharmacokinets of OmeprazoleAbsorption: Omeprazole is well absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Omeprazole is extensively metabolised in the liver.
Excretion: It is excreted mainly in the faeces and small amount in urine.
Onset of Action for Omeprazole2- 5 hoursDuration of Action for Omeprazole1 dayHalf Life of Omeprazole30 - 90 minutesSide Effects of Omeprazole1. Diarrhoea
2. Nausea
3. Vomiting
4. Abdominal pain
5. Constipation
6. Flatulence
7. Headache
8. Dry mouth
9. Dizziness
10. Myalgia
11. Rash
.Contra-indications of Omeprazole1. Hypersensitivity to OmeprazoleSpecial Precautions while taking Omeprazole1. Hepatic impairment
2. Monitor gastric malignancy
3. Avoid prolonged use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: Contraindicated
Indications for Omeprazole1. Duodenal ulcer
2. Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
5. Oesophagitis
6. Acid related dyspepsia
7. NSAID associated ulceration
8. Prophylaxis of acid aspiration during anesthesia
Interactions for OmeprazoleDiazepam: Half life of diazepam is increased.
Phenytoin: Increased plasma concentration of phenytoin.
Oral Anticoagulants: May prolong the elimination of warfarin.
Cyclosporine, Disulfiram: Omeprazole interferes with the metabolism of these drugs.
Ketaconazole, Ampicillin esters, Iron Salts: Omeprazole may interfere with the absorption of these drugs where gastric pH is a determinant of their bio-availability.Typical Dosage for OmeprazoleOral :
Adult: 10 - 20 mg / day to be taken before meals.
Duodenal ulcer: 20 mg / day to be taken 30 minutes before meals for 1-2 months.
Gastric ulcer: 20 mg / day for 1-2 months.In severe cases dose can be increased to 40 mg / day. Maintenance dose: 10 - 20 mg / day.
Zollinger- Ellison syndrome: 60 mg / day increase the dose maximum up to 360 mg/ day in 3 divided doses if needed.
Gastroesophageal reflux disease, oesophagitis: 20 mg / day for 1-2 months.
Acid related dyspepsia: 10 - 20 mg / day for 1 month.
NSAID associated ulceration: 20mg / day for 1 month.
Prophylaxis of acid aspiration during anesthesia: 40 mg in the evening before the surgery and the same dose 2 - 6 hours before the procedure.
Children: Not recommended
Schedule of OmeprazoleHStorage Requirements for OmeprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of OmeprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OmeprazoleGive supportive measures and symptomatic treatment.Home Delivery for Amoxycillin + Clarithromycin + Omeprazole in Your City
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Amoxycillin + Clarithromycin + Omeprazole is a generic medicine name and there are several brands available for it. Some of the brands for amoxycillin + clarithromycin + omeprazole might be better known than amoxycillin + clarithromycin + omeprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amoxycillin + clarithromycin + omeprazole in stock, you can ask for one of the branded alternatives for amoxycillin + clarithromycin + omeprazole.
