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- Pharmacology For Clarithromycin + Tinidazole + Omeprazole
Clarithromycin + Tinidazole + Omeprazole Pharmacology
Clarithromycin + Tinidazole + Omeprazole
About Clarithromycin + Tinidazole + OmeprazoleN/AMechanism of Action of Clarithromycin + Tinidazole + OmeprazoleN/APharmacokinets of Clarithromycin + Tinidazole + OmeprazoleN/AOnset of Action for Clarithromycin + Tinidazole + OmeprazoleN/ADuration of Action for Clarithromycin + Tinidazole + OmeprazoleN/AHalf Life of Clarithromycin + Tinidazole + OmeprazoleN/ASide Effects of Clarithromycin + Tinidazole + OmeprazoleN/AContra-indications of Clarithromycin + Tinidazole + OmeprazoleN/ASpecial Precautions while taking Clarithromycin + Tinidazole + OmeprazoleN/APregnancy Related InformationContraindicated;since Clarithromycin, Omeprazole and Tinidazole are contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated, since Clarithromycin, Omeprazole and Tinidazole are contraindicated in breast feeding, the combination generic cannot be used in breast feeding mother.Children Related InformationN/AIndications for Clarithromycin + Tinidazole + OmeprazoleIt is a combination of proton pump inhibitor Omeprazole, antimicrobial agent Tinidazole and Clarithromycin.
1.Helicobacter pylori
Interactions for Clarithromycin + Tinidazole + OmeprazoleN/ATypical Dosage for Clarithromycin + Tinidazole + OmeprazoleTake 1 tablet of Clarithromycin,Tinidazole and Omeprazole in the morning and evening for 1 week.Schedule of Clarithromycin + Tinidazole + OmeprazoleN/AStorage Requirements for Clarithromycin + Tinidazole + OmeprazoleN/AEffects of Missed Dosage of Clarithromycin + Tinidazole + OmeprazoleN/AEffects of Overdose of Clarithromycin + Tinidazole + OmeprazoleN/AClarithromycin
About ClarithromycinIt is a new macrolide antimicrobial drug.It is the most effective macrolide against Haemophilus influenzae, chlamydia trachomaitis and chlamydia pneumoniae.Mechanism of Action of ClarithromycinClarithromycin is a member of macrolide antibiotic.It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie:they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl tRNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Pharmacokinets of ClarithromycinAbsorption: Clarithromycin is completely absorbed after oral administration. Distribution: It is widely distributed in the body .Metabolism: It is metabolized in to active and inactive compound .Excretion: It is excreted through urine.Onset of Action for Clarithromycin0.5 - 1 hourDuration of Action for Clarithromycin8 - 12 hourHalf Life of ClarithromycinN/ASide Effects of Clarithromycin1.Nausea
2.Vomiting
3.Diarrhoea
4.Epigastric pain
5.Abnormal taste
6.Headache
7.Dizziness
8.Elevated hepatic enzyme
9.Pseudomembranous colitisContra-indications of Clarithromycin1.Hypersensitivity to clarithromycin and other macrolide
2.Liver diseaseSpecial Precautions while taking Clarithromycin1.Renal impairment
2.Hepatic dysfunction
3.cardiac abnormalitiesPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Clarithromycin1.Tonsilitis
2.Pharyngitis
3.Pneumonia
4.Skin and soft tissue infections
5.Bronchitis
6.Otitis media
7.Prophylaxis of MAC
8.Leprosy
9.Acne
10.NocardiosisInteractions for ClarithromycinTerfenadine: Concomitant use may cause cardiac arrhythmia.
Carbamazepine & Theophylline: Concurrent use causes increase in serum levels of these drugs.
Zidovudine: In HIV infected patients steady state Zidovudine levels decreased.
Increased efficacy of the following drugs which are metabolised by the cytochrome P450 system: Digoxin, Warfarin, Ergot alkaloids, Triazolam, Midazolam and Cyclosporine.Typical Dosage for ClarithromycinAdult: 250 - 500 mg twice daily for 1 - 2 week
Children: 7.5 mg/kg body weight two times daily for 1 - 2 week
Schedule of ClarithromycinHStorage Requirements for ClarithromycinStore in a cool dark place. Keep away from heat and moisture.Effects of Missed Dosage of ClarithromycinTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of ClarithromycinGive supportive measures and treatmentTinidazole
About TinidazoleNitroimidazole antibiotic, Antibacterial, antiprotozoal.Mechanism of Action of TinidazoleTinidazole is nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. .DNA helix destabilization &strand breakage has been observed.Pharmacokinets of TinidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by oxidation &glucuronide conjugation, Excretion: Excreted in urine.
Onset of Action for TinidazoleWithin few hoursDuration of Action for Tinidazole16 hoursHalf Life of Tinidazole12 hoursSide Effects of Tinidazole1.Anorexia
2.Bitter taste
3.Nausea
4.Vomiting
5.Diarrhoea
6.Fatigue
7.Dry mouth
8.Abdominal distress
9.Headache
10.Dizziness
11.Vertigo
12.Rash
13.Urticaria
14.Angioedema
15.Peripheral neuropathy & CNS effects,
Contra-indications of Tinidazole1.Hypersensitivity to the drug
2.Blood dyscrasias
3.CNS disorders
Special Precautions while taking Tinidazole1.Hepatic impairment
2.Alcoholic cirrhosis
3.Obstructive liver diseases
4. Use cautiously along with other hepatotoxic drugs & In visual field changes
5. Avoid alcohol use during therapy
Pregnancy Related InformationUse with caution, but contra indicated in first trimesterOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Tinidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Prophylactic agent after colorectal surgery
6.H. pylori infections
Interactions for TinidazoleAlcohol: Disulfiram like reaction.
Ampicillin, Doxycycline and Cotrimoxaole: Synergism with these agents.Typical Dosage for TinidazoleAmoebiasis:
Adults: 2gm once daily for 3 days
Children: 30 to 50mg/kg/day or 600mg 12hourly for 5 to 10 days
Trichomoniasis & Giardiasis:
600mg once daily for a week or 2gm single dose
Anaerobic bacterial infections:
2 gm followed by 500mg 12 hourly for 5 days
Prophylaxis after colorectal surgery:
2gm single dose before surgery
H. pylori infections:
0.5gm 12hourly for 7 to14 days in triple combination
Schedule of TinidazoleHStorage Requirements for TinidazoleStore at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moisture.Effects of Missed Dosage of TinidazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TinidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. For controlling seizures diazepam & phenytoin may be used Omeprazole
About OmeprazoleProton Pump Inhibitor, Substituted Benzimidazole, Anti-secretory,antiulcer.Mechanism of Action of OmeprazoleOmeprazole is a proton pump inhibitor and it is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Omeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Omeprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion.
Pharmacokinets of OmeprazoleAbsorption: Omeprazole is well absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Omeprazole is extensively metabolised in the liver.
Excretion: It is excreted mainly in the faeces and small amount in urine.
Onset of Action for Omeprazole2- 5 hoursDuration of Action for Omeprazole1 dayHalf Life of Omeprazole30 - 90 minutesSide Effects of Omeprazole1. Diarrhoea
2. Nausea
3. Vomiting
4. Abdominal pain
5. Constipation
6. Flatulence
7. Headache
8. Dry mouth
9. Dizziness
10. Myalgia
11. Rash
.Contra-indications of Omeprazole1. Hypersensitivity to OmeprazoleSpecial Precautions while taking Omeprazole1. Hepatic impairment
2. Monitor gastric malignancy
3. Avoid prolonged use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: Contraindicated
Indications for Omeprazole1. Duodenal ulcer
2. Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
5. Oesophagitis
6. Acid related dyspepsia
7. NSAID associated ulceration
8. Prophylaxis of acid aspiration during anesthesia
Interactions for OmeprazoleDiazepam: Half life of diazepam is increased.
Phenytoin: Increased plasma concentration of phenytoin.
Oral Anticoagulants: May prolong the elimination of warfarin.
Cyclosporine, Disulfiram: Omeprazole interferes with the metabolism of these drugs.
Ketaconazole, Ampicillin esters, Iron Salts: Omeprazole may interfere with the absorption of these drugs where gastric pH is a determinant of their bio-availability.Typical Dosage for OmeprazoleOral :
Adult: 10 - 20 mg / day to be taken before meals.
Duodenal ulcer: 20 mg / day to be taken 30 minutes before meals for 1-2 months.
Gastric ulcer: 20 mg / day for 1-2 months.In severe cases dose can be increased to 40 mg / day. Maintenance dose: 10 - 20 mg / day.
Zollinger- Ellison syndrome: 60 mg / day increase the dose maximum up to 360 mg/ day in 3 divided doses if needed.
Gastroesophageal reflux disease, oesophagitis: 20 mg / day for 1-2 months.
Acid related dyspepsia: 10 - 20 mg / day for 1 month.
NSAID associated ulceration: 20mg / day for 1 month.
Prophylaxis of acid aspiration during anesthesia: 40 mg in the evening before the surgery and the same dose 2 - 6 hours before the procedure.
Children: Not recommended
Schedule of OmeprazoleHStorage Requirements for OmeprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of OmeprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OmeprazoleGive supportive measures and symptomatic treatment.Home Delivery for Clarithromycin + Tinidazole + Omeprazole in Your City
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Clarithromycin + Tinidazole + Omeprazole is a generic medicine name and there are several brands available for it. Some of the brands for clarithromycin + tinidazole + omeprazole might be better known than clarithromycin + tinidazole + omeprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clarithromycin + tinidazole + omeprazole in stock, you can ask for one of the branded alternatives for clarithromycin + tinidazole + omeprazole.
