Amoxycillin + Tinidazole + Lansoprazole Pharmacology

Amoxycillin + Tinidazole + Lansoprazole

About Amoxycillin + Tinidazole + Lansoprazole
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Mechanism of Action of Amoxycillin + Tinidazole + Lansoprazole
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Pharmacokinets of Amoxycillin + Tinidazole + Lansoprazole
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Onset of Action for Amoxycillin + Tinidazole + Lansoprazole
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Duration of Action for Amoxycillin + Tinidazole + Lansoprazole
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Half Life of Amoxycillin + Tinidazole + Lansoprazole
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Side Effects of Amoxycillin + Tinidazole + Lansoprazole
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Contra-indications of Amoxycillin + Tinidazole + Lansoprazole
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Special Precautions while taking Amoxycillin + Tinidazole + Lansoprazole
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Pregnancy Related Information
Contraindicated; Tinidazole is contraindicated in 1st trimester of pregnancy so the combination generic cannot be used in pregnancy.
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated; Tinidazole is contraindicated in breast feeding so the combination generic cannot be used in lactating mother
Children Related Information
N/A
Indications for Amoxycillin + Tinidazole + Lansoprazole
H. pylori infection
The combination of these three drugs works better to kill the bacteria than the antibiotics alone. It is a very effective combination to eradicate H. pylori infection in ulcer patients
Interactions for Amoxycillin + Tinidazole + Lansoprazole
N/A
Typical Dosage for Amoxycillin + Tinidazole + Lansoprazole
Adult: 1 kit 2 times daily for 7 - 10 days
Each kit contains Amoxycillin 750mg + Tinidazole 500mg + Lansoprazole 30mg
Schedule of Amoxycillin + Tinidazole + Lansoprazole
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Storage Requirements for Amoxycillin + Tinidazole + Lansoprazole
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Effects of Missed Dosage of Amoxycillin + Tinidazole + Lansoprazole
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Effects of Overdose of Amoxycillin + Tinidazole + Lansoprazole
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Amoxycillin

About Amoxycillin
Semisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative.
Mechanism of Action of Amoxycillin
Amoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once.
Pharmacokinets of Amoxycillin
Absorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted
in breast milk
Onset of Action for Amoxycillin
60 -120 minutes
Duration of Action for Amoxycillin
6-8 hours
Half Life of Amoxycillin
60 minutes
Side Effects of Amoxycillin
1.Aaphylaxis
2. Vomiting
3.Diarrhoea
4 Nausea
5.Rash
6.Urticaria
7.Thrombocytopenia
8.Nephritis
9.Seizure
10.Super infections.
Contra-indications of Amoxycillin
Hypersensitivity to Amoxicillin and other Penicillins.
Special Precautions while taking Amoxycillin
1.Mononucleosis
2.Lymphatic leukaemia
3.HIV infections
4.Hepatic impairment
5.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Amoxycillin
1Urinary tract infections
2.Gonorrhoea
3 Meningitis
4.SABE
5.Respiratory tract infections
6.Septicemia
7.Soft tissue infections
8.Otitis media
9.Sinusitis
10.Tetanus
11.Biliarytract infections
12.Bronchitis
13.Salmonellosis
14.Typhoid
15.Gastroenteritis
16.Chlamydia infection
17.Paratyphoid fever
18.Dental infections
Interactions for Amoxycillin
Oral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Erythromycin, Tetracycline: Reduce efficacy.
Typical Dosage for Amoxycillin
ADULT: 250 - 500 mg three to four times daily.
In severe infections dose can be increased to 3 - 6 g daily depending on the severity of infection.
CHILDREN:125 - 250 mg three to four times a day depending on the severity of infection.
Schedule of Amoxycillin
H
Storage Requirements for Amoxycillin
It should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Amoxycillin
Take the dose as soon as noticed and if it is the time to the next dose then skip the missed dose
Effects of Overdose of Amoxycillin
Give supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed.

Tinidazole

About Tinidazole
Nitroimidazole antibiotic, Antibacterial, antiprotozoal.
Mechanism of Action of Tinidazole
Tinidazole is nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. .DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of Tinidazole
Absorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by oxidation &glucuronide conjugation, Excretion: Excreted in urine.
Onset of Action for Tinidazole
Within few hours
Duration of Action for Tinidazole
16 hours
Half Life of Tinidazole
12 hours
Side Effects of Tinidazole
1.Anorexia
2.Bitter taste
3.Nausea
4.Vomiting
5.Diarrhoea
6.Fatigue
7.Dry mouth
8.Abdominal distress
9.Headache
10.Dizziness
11.Vertigo
12.Rash
13.Urticaria
14.Angioedema
15.Peripheral neuropathy & CNS effects,
Contra-indications of Tinidazole
1.Hypersensitivity to the drug
2.Blood dyscrasias
3.CNS disorders
Special Precautions while taking Tinidazole
1.Hepatic impairment
2.Alcoholic cirrhosis
3.Obstructive liver diseases
4. Use cautiously along with other hepatotoxic drugs & In visual field changes
5. Avoid alcohol use during therapy
Pregnancy Related Information
Use with caution, but contra indicated in first trimester
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Tinidazole
1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Prophylactic agent after colorectal surgery
6.H. pylori infections
Interactions for Tinidazole
Alcohol: Disulfiram like reaction.
Ampicillin, Doxycycline and Cotrimoxaole: Synergism with these agents.
Typical Dosage for Tinidazole
Amoebiasis:
Adults: 2gm once daily for 3 days
Children: 30 to 50mg/kg/day or 600mg 12hourly for 5 to 10 days
Trichomoniasis & Giardiasis:
600mg once daily for a week or 2gm single dose
Anaerobic bacterial infections:
2 gm followed by 500mg 12 hourly for 5 days
Prophylaxis after colorectal surgery:
2gm single dose before surgery
H. pylori infections:
0.5gm 12hourly for 7 to14 days in triple combination
Schedule of Tinidazole
H
Storage Requirements for Tinidazole
Store at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moisture.
Effects of Missed Dosage of Tinidazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tinidazole
Treatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. For controlling seizures diazepam & phenytoin may be used

Lansoprazole

About Lansoprazole
A proton pump inhibitor, Benzimidazole derivative, Anti ulcer.
Mechanism of Action of Lansoprazole
Lansoprazole is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Lansoprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Lansoprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion.
Pharmacokinets of Lansoprazole
Absorption: Lansoprazole is well absorbed after oral administration.Distribution: It is widely distributed in the body in protein bound form.Metabolism: Lansoprazole is extensively metabolised in the liver.Excretion: It is excreted mainly in the faeces and small amount in urine.
Onset of Action for Lansoprazole
1- 2 hours
Duration of Action for Lansoprazole

1 day

Half Life of Lansoprazole
30- 90 minutes

Side Effects of Lansoprazole
1.Diarrhoea
2.Nausea
3.Vomiting
4.Abdominal pain
5.Constipation
6.Stomatitis
7.Agitation
8.Dizziness
9.Myalgia
10. Rash


Contra-indications of Lansoprazole
Hypersensitivity to Lansoprazole

Special Precautions while taking Lansoprazole
1.Hepatic impairment
2.Monitor gastric malignancy
3.Avoid prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated

NEONATES: Contraindicated
Indications for Lansoprazole
1. Duodenal ulcer
2. Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
5. Oesophagitis
6. Acid related dyspepsia
7. NSAID associated ulceration



Interactions for Lansoprazole
Antacids: Bio-availability of lansoprazole reduced.
Oral contraceptives, Phenytoin, Theophylline and Warfarin: Caution should be exercised while using these drugs which are metabolised by the liver since lansoprazole is a weak inducer of P450 cytochrome.
Typical Dosage for Lansoprazole
Adult: 15 - 30 mg / day to be taken before meals.
Duodenal ulcer: 15 mg / day before meals for 1 month.
Gastric ulcer: 30 mg / day for 2 months.
Zollinger- Ellison syndrome: 60 mg / day increase the dose to 180 mg/ day in 2 divided doses if needed.
Gastroesophageal reflux disease: 15 mg / day for 2 months.
Oesophagitis: 30 mg / day before meals for 2 months continue the treatment for 2 more months if needed.
Acid related dyspepsia: 15 - 30 mg / day before breakfast for 1 month.
NSAID associated ulceration: 15 - 30 mg / day for 1 - 2 months.

Children: not recommended
Schedule of Lansoprazole
H
Storage Requirements for Lansoprazole
Store at 15 - 30 degree C in a tightly closed container. Protect from light.
Effects of Missed Dosage of Lansoprazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Lansoprazole
Give supportive measures and symptomatic treatment.

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