Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine Pharmacology

Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine

About Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Mechanism of Action of Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Pharmacokinets of Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Onset of Action for Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Duration of Action for Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Half Life of Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Side Effects of Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Contra-indications of Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Special Precautions while taking Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Pregnancy Related Information
Use with caution
Old Age Related Information
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Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
Oxethazaine is a local anaesthetic which provides prompt relief of pain. Oxethazaine is stable at the levels of acidity or alkalinity found in the upper gastrointestinal tract and has relatively prolonged action. Antacids and antiflatulent takes care of hyperacidity and gas.
1.Relief of pain and hyperacidity associated with gastritis, esophagitis of any cause
2.Peptic ulcer
3.Hiatal hernia
4.Flatulence
Interactions for Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
N/A
Typical Dosage for Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
Adult: 5 - 10ml to be taken 15minutes before each meal.
Schedule of Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Storage Requirements for Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Effects of Missed Dosage of Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Effects of Overdose of Aluminium Hydroxide + Dimethicone + Magnesium Hydroxide + Oxethazaine
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Aluminium Hydroxide

About Aluminium Hydroxide
Antacid,Antidote,Protectant( Topical), In hyperacidity; hyperphosphatemia.
Mechanism of Action of Aluminium Hydroxide
It neutralizes and reduces stomach acid relieving heartburn (acid reflux, GERD) and indigestion. This results increased pH and reduce the pepsin activity. It also binds to the phosphate in the gut and form a nonsoluble nonabsorbable aluminium phosphate complex.
Pharmacokinets of Aluminium Hydroxide
Absorption- Poorly absorbed.Excretion- Excreted through feces and breast milk
Onset of Action for Aluminium Hydroxide
N/A
Duration of Action for Aluminium Hydroxide
20 to 180minutes
Half Life of Aluminium Hydroxide
N/A
Side Effects of Aluminium Hydroxide
1. Loss of appetite
2. Constipation
3. Hypophosphatemia
4. Osteomalacia
5. Confusion
6. Unusual tiredness or discomfort
7. Muscle weakness
8. Encephalopathy
Contra-indications of Aluminium Hydroxide
1. Hypersensitivity to the drug
2. Renal failure
3. Hypertension
4. Heart disease
5. Kidney disease
6. Gastrointestinal bleeding.
Special Precautions while taking Aluminium Hydroxide
1. Stomach problems
2. Allergies
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Aluminium Hydroxide
1. Gastric hyperacidity
2. Ulcers
3. Digestive disorders
4. Hyperphosphatemia
5. Oesophagitis
6. Hiatal hernia
7. Gastritis
Interactions for Aluminium Hydroxide
N/A
Typical Dosage for Aluminium Hydroxide
Oral-
Acidity and Hyperphosphatemia -
Adult-
500-1500mg tablet or capsule 1 hr after meals and at bed time
5 to 30 ml suspension1 hr after meals and at bed time as needed
Schedule of Aluminium Hydroxide
N/A
Storage Requirements for Aluminium Hydroxide
Store it at room temperature and away from excess heat and moisture. Refrigerate the suspension. Do not freeze.
Effects of Missed Dosage of Aluminium Hydroxide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Aluminium Hydroxide
Give symptomatic and supportive treatment

Dimethicone

About Dimethicone
Oral anti -foaming agent, a flexible silicone polymer, Antiflatulent ,Antibloating agent.
Mechanism of Action of Dimethicone
Activated Dimethicone relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas. The most common antigas material is Dimethicone and when mixed with silicone dioxide becomes Simethicone. Simethicone is also referred to as activated Dimethicone. Simethicone is the most common antigas material and may be the only drug approved antiflatulent.
As the antacid chewing tablet is chewed, the active antacid and antiflatulent in the gum coating is released into the saliva and ingested to give relief from gastrointestinal disturbances in the gastro-intestinal tract.
Besides its antigas effect, Simethicone used in a gum coating can also improve the smoothness of the coating. Activated Dimethicone helps to relieve pain and bloating caused by trapped wind.
Pharmacokinets of Dimethicone
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Onset of Action for Dimethicone
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Duration of Action for Dimethicone
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Half Life of Dimethicone
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Side Effects of Dimethicone
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Contra-indications of Dimethicone
Hypersensitivity to Dimethicone activated
Special Precautions while taking Dimethicone
Kidney failure
Pregnancy Related Information
Use with caution
Old Age Related Information
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Breast Feeding Related Information
Use with caution
Children Related Information
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Indications for Dimethicone
1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Dimethicone
N/A
Typical Dosage for Dimethicone
125 - 166 mg taken half an hour before food.
Dimethicone in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Dimethicone
Schedule of Dimethicone
N/A
Storage Requirements for Dimethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Dimethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dimethicone
Give symptomatic and supportive treatment.

Magnesium Hydroxide

About Magnesium Hydroxide
Mineral, Magnesium compound, Antacid and laxative.
Mechanism of Action of Magnesium Hydroxide
It neutralize the gastric acid (where the hydroxide ions from the Mg(OH)2 combine with acidic H+ ions produced in the form of hydrochloric acid by parietal cells in the stomach). This relieves the hyperacidity problems in the stomach.
Pharmacokinets of Magnesium Hydroxide
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Onset of Action for Magnesium Hydroxide
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Duration of Action for Magnesium Hydroxide
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Half Life of Magnesium Hydroxide
N/A
Side Effects of Magnesium Hydroxide
1. Stomach cramps
2. Upset stomach
3. Vomiting
4. Diarrhea
5. Black/tarry stools
6. Rectal bleeding.
7. Constipation
8. Loss of appetite
9. Unusual tiredness
10. Muscle weakness
11. Hypermagnesaemia
12. Renal failure
Contra-indications of Magnesium Hydroxide
1. Hypersensitivity to the drug
2. Kidney disease
3. Stomach/abdominal pain
4. Nausea
5. Vomiting
Special Precautions while taking Magnesium Hydroxide
1. Colostomy
2. Dehydration
3. Diarrhea
4. Intestinal problems like colitis
5.Do not take any other medication within 1 to 2 hours of taking this medication.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Less than 6 Years : Contraindicated
Indications for Magnesium Hydroxide
1. Constipation
2. Peptic ulcer
3. Hiatal hernia
Interactions for Magnesium Hydroxide
N/A
Typical Dosage for Magnesium Hydroxide
Oral-
Adult-
Antacid:
Tab-500mg to 1.5g daily.
Liquid-5-15ml daily.
Laxative:
Tab-2.4-4.8g daily.
Liquid -30-60ml daily.
Schedule of Magnesium Hydroxide
N/A
Storage Requirements for Magnesium Hydroxide
Store it at room temperature (15-30 degree C) and away from excess heat and moisture.
Effects of Missed Dosage of Magnesium Hydroxide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Magnesium Hydroxide
Give symptomatic and supportive treatment.

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