Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide Pharmacology

Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide

About Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Mechanism of Action of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Pharmacokinets of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Onset of Action for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Duration of Action for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Half Life of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Side Effects of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Contra-indications of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Special Precautions while taking Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
Dimethicone is added to an antacid as an antifoaming agent to relieve flatulence. It is also useful for the relief of hiccup.
1.Hyperacidity
2.Peptic ulcer
Interactions for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
N/A
Typical Dosage for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
1 - 2 tablets to be chewed 30 - 60 minutes after meals 3 - 4 times daily.
Schedule of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Storage Requirements for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Effects of Missed Dosage of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Effects of Overdose of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
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Aluminium Hydroxide

About Aluminium Hydroxide
Antacid,Antidote,Protectant( Topical), In hyperacidity; hyperphosphatemia.
Mechanism of Action of Aluminium Hydroxide
It neutralizes and reduces stomach acid relieving heartburn (acid reflux, GERD) and indigestion. This results increased pH and reduce the pepsin activity. It also binds to the phosphate in the gut and form a nonsoluble nonabsorbable aluminium phosphate complex.
Pharmacokinets of Aluminium Hydroxide
Absorption- Poorly absorbed.Excretion- Excreted through feces and breast milk
Onset of Action for Aluminium Hydroxide
N/A
Duration of Action for Aluminium Hydroxide
20 to 180minutes
Half Life of Aluminium Hydroxide
N/A
Side Effects of Aluminium Hydroxide
1. Loss of appetite
2. Constipation
3. Hypophosphatemia
4. Osteomalacia
5. Confusion
6. Unusual tiredness or discomfort
7. Muscle weakness
8. Encephalopathy
Contra-indications of Aluminium Hydroxide
1. Hypersensitivity to the drug
2. Renal failure
3. Hypertension
4. Heart disease
5. Kidney disease
6. Gastrointestinal bleeding.
Special Precautions while taking Aluminium Hydroxide
1. Stomach problems
2. Allergies
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Aluminium Hydroxide
1. Gastric hyperacidity
2. Ulcers
3. Digestive disorders
4. Hyperphosphatemia
5. Oesophagitis
6. Hiatal hernia
7. Gastritis
Interactions for Aluminium Hydroxide
N/A
Typical Dosage for Aluminium Hydroxide
Oral-
Acidity and Hyperphosphatemia -
Adult-
500-1500mg tablet or capsule 1 hr after meals and at bed time
5 to 30 ml suspension1 hr after meals and at bed time as needed
Schedule of Aluminium Hydroxide
N/A
Storage Requirements for Aluminium Hydroxide
Store it at room temperature and away from excess heat and moisture. Refrigerate the suspension. Do not freeze.
Effects of Missed Dosage of Aluminium Hydroxide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Aluminium Hydroxide
Give symptomatic and supportive treatment

Calcium

About Calcium
Calcium is necessary for cardiac function, muscle contraction, nervous activity, coagulation of blood and for maintaining structural integrity of cell membranes.
Plasma concentration of calcium is kept in normal range by three endocrine factors which control metabolism of calcium. These are (a) Parathyroid hormone, (b) Calcitonin, (c) Vitamin D. Calcium in plasma is bound to albumin, is complexed with anions (e.g. phosphate) and as diffusible ionic calcium. The physiological effects are exerted by ionic calcium. The predominant source of calcium is dairy products and the daily intake varies from 200 - 2500 mg. Adequate calcium intake is particularly important during periods of bone growth in childhood and adolescence and during pregnancy and lactation.
Patients with advanced renal insufficiency exhibit phosphate retention and some degree of hyperphosphataemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy and soft tissue calcification. Calcium acetate, when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the faeces.
Deficiency signs and symptoms: Osteoporosis, pathological fractures, brittle nails and hair.
Mechanism of Action of Calcium
Calcium is essential for maintaining the functional integrity of nervous, muscular, and skeletal system. It controls excitability of nerves and muscles and regulates permeability of cell membrane. It also regulates cell adhesion and maintains integrity of cell membrane. Calcium acts as intracellular messenger for hormones, autacoids, and transmitters. It is required for excitation-contraction coupling in all types of muscle and excitation-secretion coupling in exocrine and endocrine glands. It is essential for release of transmitters from nerve endings and other release reactions. It is also essential for impulse generation in heart and determines level of automaticity and
A-V conduction. Calcium is also required for blood-coagulation.
Pharmacokinets of Calcium
Absorption: Actively absorbed from gastrointestinal tract in an ionized form; and vitamin D in it`s active form is required for calcium absorption, Distribution: Distributed mainly in to skeletal tissue (99%) and 1% is distributed equally between the intracellular and extra cellular fluid. CSF levels are about half of the serum calcium levels, Metabolism: Not significantly metabolized in the body, Excretion: Excreted mainly through faeces and a small amount is excreted through urine.
Onset of Action for Calcium
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Duration of Action for Calcium
N/A
Half Life of Calcium
N/A
Side Effects of Calcium
1.Constipation
2.Bloating
3.Excess gas
4.Anorexia
5.Nausea
6.Vomiting
7.Abdominal pain
8.Thirst
9.Hypercalcaemia
10.Polyuria
11.Dry mouth
12.Delirium
13.Confusion
Contra-indications of Calcium
1.Renal calculi
2.Hypophosphataemia
3.Hypercalcaemia
4.Ventricular fibrillation.
Special Precautions while taking Calcium
1.Renal impairment
2.Cardiac diseases
3.Sarcoidosis
4.Cor pulmonale
5.Respiratory acidosis
6.Respiratory failure
7.End stage renal failure
8.Hypoparathyroid patients
9.Digitalized patients
10.Prolonged use of therapeutic amounts.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
Indications for Calcium
1.Hypocalcaemia
2.Calcium and vitamin D deficiency
3.Calcium deficiency during pregnancy and lactation
4.Rickets
5.Prevention of osteoporosis in postmenopausal women
6.Chronic renal failure.
Interactions for Calcium
N/A
Typical Dosage for Calcium
Oral: 500mg to 2g daily in two to four divided doses.
Hypocalcaemia:
Adults: 1g daily. Increases to 2g daily if required.
Prevention of osteoporosis: 1 to 1.5g daily.
Children: 45 to 65mg/kg daily.
Neonates: 50 to 150mg/kg and should not exceed 1g.

Schedule of Calcium
N/A
Storage Requirements for Calcium
Store in a well closed container in a cool and dry place. Protect from light.


Effects of Missed Dosage of Calcium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Calcium
Remove calcium from stomach by induced emesis and gastric lavage. Provide symptomatic treatment and supportive measures.

Dimethicone

About Dimethicone
Oral anti -foaming agent, a flexible silicone polymer, Antiflatulent ,Antibloating agent.
Mechanism of Action of Dimethicone
Activated Dimethicone relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas. The most common antigas material is Dimethicone and when mixed with silicone dioxide becomes Simethicone. Simethicone is also referred to as activated Dimethicone. Simethicone is the most common antigas material and may be the only drug approved antiflatulent.
As the antacid chewing tablet is chewed, the active antacid and antiflatulent in the gum coating is released into the saliva and ingested to give relief from gastrointestinal disturbances in the gastro-intestinal tract.
Besides its antigas effect, Simethicone used in a gum coating can also improve the smoothness of the coating. Activated Dimethicone helps to relieve pain and bloating caused by trapped wind.
Pharmacokinets of Dimethicone
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Onset of Action for Dimethicone
N/A
Duration of Action for Dimethicone
N/A
Half Life of Dimethicone
N/A
Side Effects of Dimethicone
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Contra-indications of Dimethicone
Hypersensitivity to Dimethicone activated
Special Precautions while taking Dimethicone
Kidney failure
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Dimethicone
1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Dimethicone
N/A
Typical Dosage for Dimethicone
125 - 166 mg taken half an hour before food.
Dimethicone in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Dimethicone
Schedule of Dimethicone
N/A
Storage Requirements for Dimethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Dimethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dimethicone
Give symptomatic and supportive treatment.

Magnesium Hydroxide

About Magnesium Hydroxide
Mineral, Magnesium compound, Antacid and laxative.
Mechanism of Action of Magnesium Hydroxide
It neutralize the gastric acid (where the hydroxide ions from the Mg(OH)2 combine with acidic H+ ions produced in the form of hydrochloric acid by parietal cells in the stomach). This relieves the hyperacidity problems in the stomach.
Pharmacokinets of Magnesium Hydroxide
N/A
Onset of Action for Magnesium Hydroxide
N/A
Duration of Action for Magnesium Hydroxide
N/A
Half Life of Magnesium Hydroxide
N/A
Side Effects of Magnesium Hydroxide
1. Stomach cramps
2. Upset stomach
3. Vomiting
4. Diarrhea
5. Black/tarry stools
6. Rectal bleeding.
7. Constipation
8. Loss of appetite
9. Unusual tiredness
10. Muscle weakness
11. Hypermagnesaemia
12. Renal failure
Contra-indications of Magnesium Hydroxide
1. Hypersensitivity to the drug
2. Kidney disease
3. Stomach/abdominal pain
4. Nausea
5. Vomiting
Special Precautions while taking Magnesium Hydroxide
1. Colostomy
2. Dehydration
3. Diarrhea
4. Intestinal problems like colitis
5.Do not take any other medication within 1 to 2 hours of taking this medication.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Less than 6 Years : Contraindicated
Indications for Magnesium Hydroxide
1. Constipation
2. Peptic ulcer
3. Hiatal hernia
Interactions for Magnesium Hydroxide
N/A
Typical Dosage for Magnesium Hydroxide
Oral-
Adult-
Antacid:
Tab-500mg to 1.5g daily.
Liquid-5-15ml daily.
Laxative:
Tab-2.4-4.8g daily.
Liquid -30-60ml daily.
Schedule of Magnesium Hydroxide
N/A
Storage Requirements for Magnesium Hydroxide
Store it at room temperature (15-30 degree C) and away from excess heat and moisture.
Effects of Missed Dosage of Magnesium Hydroxide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Magnesium Hydroxide
Give symptomatic and supportive treatment.

Home Delivery for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide in Your City

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