Paracetamol + Racemethionine Pharmacology

Paracetamol + Racemethionine

About Paracetamol + Racemethionine
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Mechanism of Action of Paracetamol + Racemethionine
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Pharmacokinets of Paracetamol + Racemethionine
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Onset of Action for Paracetamol + Racemethionine
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Duration of Action for Paracetamol + Racemethionine
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Half Life of Paracetamol + Racemethionine
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Side Effects of Paracetamol + Racemethionine
N/A
Contra-indications of Paracetamol + Racemethionine
N/A
Special Precautions while taking Paracetamol + Racemethionine
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Paracetamol + Racemethionine
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Interactions for Paracetamol + Racemethionine
N/A
Typical Dosage for Paracetamol + Racemethionine
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Schedule of Paracetamol + Racemethionine
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Storage Requirements for Paracetamol + Racemethionine
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Effects of Missed Dosage of Paracetamol + Racemethionine
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Effects of Overdose of Paracetamol + Racemethionine
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Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Racemethionine

About Racemethionine
A sulfur containing essential amino acid , Urinary Acidifier, paracetamol antidote.
Mechanism of Action of Racemethionine
Racemethionine is a urine acidifier. Racemethionine produces ammonia-free urine by lowering the urinary pH. Along with Paracetamol, Racemethionine provides a liver friendly analgesic and antipyretic Acidifier.
Racemethionine enhances the synthesis of glutathione and is used as an alternative to Acetylcysteine in the treatment of paracetamol poisoning to prevent hepatotoxicity.
It maintain hepatic concentrations of glutathione which is required to inactivate an hepatotoxic intermediate metabolite of acetaminophen.In acetaminophen overdose, excessive quantities of this metabolite are formed because the primary metabolic pathways (glucuronide and sulfate conjugation) become saturated. The excess metabolite binds irreversibly to essential hepatic proteins and enzymes, causing cell damage and death. Racemethionine serves as a precursor for the synthesis of glutathione and sulfate.

Pharmacokinets of Racemethionine
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Onset of Action for Racemethionine
N/A
Duration of Action for Racemethionine
N/A
Half Life of Racemethionine
N/A
Side Effects of Racemethionine
1.Drowsiness
2.Nausea
3.Vomiting
Contra-indications of Racemethionine
1.Acidosis
2.Severe liver disease
Special Precautions while taking Racemethionine
1.Acidosis
2.Hepatic impairment
3.Allergies
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Racemethionine
1. Urinary acidifier
2. Paracetamol poisoning
Interactions for Racemethionine
N/A
Typical Dosage for Racemethionine
As directed by the physician
As urinary acidifier:
Adults : 200 mg 3 or 4 times a day.
Children: Same as adult dose


Schedule of Racemethionine
N/A
Storage Requirements for Racemethionine
Store away from heat and direct light. Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.

Effects of Missed Dosage of Racemethionine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Do not double the dose. Continue the regular schedule
Effects of Overdose of Racemethionine
Give supportive measures and symptomatic treatment.

Home Delivery for Paracetamol + Racemethionine in Your City

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Paracetamol + Racemethionine is a generic medicine name and there are several brands available for it. Some of the brands for paracetamol + racemethionine might be better known than paracetamol + racemethionine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have paracetamol + racemethionine in stock, you can ask for one of the branded alternatives for paracetamol + racemethionine.