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- Pharmacology For Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + Diazepam
Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + Diazepam Pharmacology
Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + Diazepam
About Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/AMechanism of Action of Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/APharmacokinets of Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/AOnset of Action for Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/ADuration of Action for Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/AHalf Life of Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/ASide Effects of Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/AContra-indications of Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/ASpecial Precautions while taking Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamMethyl Polysiloxane is added to an antacid as an antifoaming agent to relieve flatulence. It is also useful for the relief of hiccup. Antacids and antiflatulent takes care of hyperacidity and gas.Diazepam is used for sedation.
1.Hyperacdity
2.Flatulence
Interactions for Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/ATypical Dosage for Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + Diazepam1 - 2 tablet to be taken 3 - 4 times daily.Schedule of Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/AStorage Requirements for Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/AEffects of Missed Dosage of Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/AEffects of Overdose of Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + DiazepamN/AAluminium Hydroxide
About Aluminium HydroxideAntacid,Antidote,Protectant( Topical), In hyperacidity; hyperphosphatemia.Mechanism of Action of Aluminium HydroxideIt neutralizes and reduces stomach acid relieving heartburn (acid reflux, GERD) and indigestion. This results increased pH and reduce the pepsin activity. It also binds to the phosphate in the gut and form a nonsoluble nonabsorbable aluminium phosphate complex.Pharmacokinets of Aluminium HydroxideAbsorption- Poorly absorbed.Excretion- Excreted through feces and breast milkOnset of Action for Aluminium HydroxideN/ADuration of Action for Aluminium Hydroxide20 to 180minutesHalf Life of Aluminium HydroxideN/ASide Effects of Aluminium Hydroxide1. Loss of appetite
2. Constipation
3. Hypophosphatemia
4. Osteomalacia
5. Confusion
6. Unusual tiredness or discomfort
7. Muscle weakness
8. Encephalopathy
Contra-indications of Aluminium Hydroxide1. Hypersensitivity to the drug
2. Renal failure
3. Hypertension
4. Heart disease
5. Kidney disease
6. Gastrointestinal bleeding.
Special Precautions while taking Aluminium Hydroxide1. Stomach problems
2. Allergies
Pregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Aluminium Hydroxide1. Gastric hyperacidity
2. Ulcers
3. Digestive disorders
4. Hyperphosphatemia
5. Oesophagitis
6. Hiatal hernia
7. Gastritis
Interactions for Aluminium HydroxideN/ATypical Dosage for Aluminium HydroxideOral-
Acidity and Hyperphosphatemia -
Adult-
500-1500mg tablet or capsule 1 hr after meals and at bed time
5 to 30 ml suspension1 hr after meals and at bed time as needed
Schedule of Aluminium HydroxideN/AStorage Requirements for Aluminium HydroxideStore it at room temperature and away from excess heat and moisture. Refrigerate the suspension. Do not freeze.Effects of Missed Dosage of Aluminium HydroxideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Aluminium HydroxideGive symptomatic and supportive treatmentMagnesium Hydroxide
About Magnesium HydroxideMineral, Magnesium compound, Antacid and laxative.Mechanism of Action of Magnesium HydroxideIt neutralize the gastric acid (where the hydroxide ions from the Mg(OH)2 combine with acidic H+ ions produced in the form of hydrochloric acid by parietal cells in the stomach). This relieves the hyperacidity problems in the stomach.Pharmacokinets of Magnesium HydroxideN/AOnset of Action for Magnesium HydroxideN/ADuration of Action for Magnesium HydroxideN/AHalf Life of Magnesium HydroxideN/ASide Effects of Magnesium Hydroxide1. Stomach cramps
2. Upset stomach
3. Vomiting
4. Diarrhea
5. Black/tarry stools
6. Rectal bleeding.
7. Constipation
8. Loss of appetite
9. Unusual tiredness
10. Muscle weakness
11. Hypermagnesaemia
12. Renal failure
Contra-indications of Magnesium Hydroxide1. Hypersensitivity to the drug
2. Kidney disease
3. Stomach/abdominal pain
4. Nausea
5. Vomiting
Special Precautions while taking Magnesium Hydroxide1. Colostomy
2. Dehydration
3. Diarrhea
4. Intestinal problems like colitis
5.Do not take any other medication within 1 to 2 hours of taking this medication.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationLess than 6 Years : ContraindicatedIndications for Magnesium Hydroxide1. Constipation
2. Peptic ulcer
3. Hiatal herniaInteractions for Magnesium HydroxideN/ATypical Dosage for Magnesium HydroxideOral-
Adult-
Antacid:
Tab-500mg to 1.5g daily.
Liquid-5-15ml daily.
Laxative:
Tab-2.4-4.8g daily.
Liquid -30-60ml daily.
Schedule of Magnesium HydroxideN/AStorage Requirements for Magnesium HydroxideStore it at room temperature (15-30 degree C) and away from excess heat and moisture.Effects of Missed Dosage of Magnesium HydroxideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Magnesium HydroxideGive symptomatic and supportive treatment.Methyl Polysiloxane
About Methyl PolysiloxaneSiloxanes, Antiflatulent.Mechanism of Action of Methyl PolysiloxaneMethyl Polysiloxane relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas.Pharmacokinets of Methyl PolysiloxaneN/AOnset of Action for Methyl PolysiloxaneN/ADuration of Action for Methyl PolysiloxaneN/AHalf Life of Methyl PolysiloxaneN/ASide Effects of Methyl PolysiloxaneN/AContra-indications of Methyl PolysiloxaneHypersensitivity to Methyl PolysiloxaneSpecial Precautions while taking Methyl PolysiloxaneKidney failurePregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Methyl Polysiloxane1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Methyl PolysiloxaneN/ATypical Dosage for Methyl Polysiloxane125 - 166 mg taken half an hour before food.
Methyl Polysiloxane in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Methyl Polysiloxane
Schedule of Methyl PolysiloxaneN/AStorage Requirements for Methyl PolysiloxaneStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of Methyl PolysiloxaneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Methyl PolysiloxaneGive symptomatic and supportive treatment.Diazepam
About DiazepamA benzodiazepine derivative with CNS depressant, Anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant and amnestic.Mechanism of Action of DiazepamDiazepam mainly acts on Limbic system and ascending reticular formation in the CNS and binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will produce an increase in the concentration of the inhibitory neurotransmitter GABA and chloride ions and decreases firing rate of neuron. These in turn alters normal functions of the body.
Antivertigo action: Although intravenous diazepam has been used to abort acute attacks of vertigo of peripheral origin, it can prolong compensation and recovery from vestibular lesions
Pharmacokinets of DiazepamAbsorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised to active metabolite (((Desmethyl diazepam))) in the liver. Excretion: Most metabolites are excreted in urineOnset of Action for Diazepam0.5 - 2 hourDuration of Action for Diazepam1 dayHalf Life of Diazepam20 - 100 hourSide Effects of Diazepam1.Ataxia
2.Drowsiness
3.Lethargy
4.Hallucination
5.Nausea
6.Constipation
7.Amnesia
8.Dependence
9. Tremor
10.Confusion
11.Light headedness
12.Mood changes
13.Muscle cramp
14. Drug dependence
15.Respiratory depression
Contra-indications of Diazepam1.Hypersensitivity to Benzodiazepines
2.Acute narrow angle glaucoma.Special Precautions while taking Diazepam1.Renal impairment
2.Hepatic impairment
3.Open angle glaucoma
4.Depression
5.Pulmonary insufficiency
6.Epileptic patients
7.Driving vehicles, operating machines and other hazardous activities
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationUse with caution
NEONATES contraindicated:Indications for Diazepam1.Anxiety
2.Preanaesthetic medication
3.Insomnia
4.Treatment of Febrile seizure and Status epilepticus
5.Acute alcohol withdrawal syndrome,
6.Relief of muscle spasm
7.Tetanus
8.Eclampsia
9.General anaesthesia
10. Vertigo.Interactions for DiazepamAlcohol and other CNS depressants: Enhanced CNS effects.
Aminophylline: Antagonizes the sedative effect.
Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranalol, Valproic Acid: Elimination of diazepam decreased due to inhibition of hepatic metabolism leading to enhanced activity.
Digoxin, Imipiramine & Desipramine: Enhanced activity of these drugs.
Levodopa: Decrease in antiparkinsonism efficacy.
Ranitidine: Decreases GI absorption of Diazepam.
Rifampicin: Decreases efficacy.Typical Dosage for DiazepamAdult: 4 - 30 mg/day in 2 - 4 divided doses
Anxiety: 2 -10 mg 2 - 3 times a day; depending on the severity of the disease.
Muscle spasm: 2 -10 mg every 2 - 3 times a day; depending on the severity of the disease.
Acute alcohol withdrawal syndrome: Initial dose: 30 - 40 mg / day in 3 - 4 divided doses; if needed the dose can be reduced to 15 - 20 mg / day in divided doses.
Status epilepticus : 0.2 - 0.5 mg/ kg body weight as IV infusion followed by repeated doses.
PAM (((IM))): 5 - 10 mg before surgery
Children:
Anxiety: 3 - 10 mg / day in 3 - 4 divided dose. As needed dose can be increased gradually
Tetanus (((IM/IV infusion))): 1- 10 mg; repeated every 3 - 4 hour; dose is selected depending on the age and severity of the disease.
Status epilepticus :Above 7 years: 5 mg IV over 5 minutes; the dose may be repeated every 2 - 4 hour as needed; maximum dose: 10 mg
Status epilepticus 1 - 7 years: 2.5 mg IV over 5 minutes; the dose may be repeated every 2 - 4 hour as needed; maximum dose: 5mg
Schedule of DiazepamHStorage Requirements for DiazepamThe drug should be kept at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of DiazepamTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of DiazepamGive support and symptomatic treatment. Flumazenil can be given as antagonist. Hypotension can be treated with vasopressors.If the patient is conscious induce emesis followed by charcoal administrationHome Delivery for Aluminium hydroxide + Magnesium Hydroxide + Methyl Polysiloxane + Diazepam in Your City
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