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- Pharmacology For Domperidone + Magaldrate + Simethicone
Domperidone + Magaldrate + Simethicone Pharmacology
Domperidone + Magaldrate + SimethiconeAbout Domperidone + Magaldrate + SimethiconeN/AMechanism of Action of Domperidone + Magaldrate + SimethiconeN/APharmacokinets of Domperidone + Magaldrate + SimethiconeN/AOnset of Action for Domperidone + Magaldrate + SimethiconeN/ADuration of Action for Domperidone + Magaldrate + SimethiconeN/AHalf Life of Domperidone + Magaldrate + SimethiconeN/ASide Effects of Domperidone + Magaldrate + SimethiconeN/AContra-indications of Domperidone + Magaldrate + SimethiconeN/ASpecial Precautions while taking Domperidone + Magaldrate + SimethiconeN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Domperidone + Magaldrate + SimethiconeN/AInteractions for Domperidone + Magaldrate + SimethiconeN/ATypical Dosage for Domperidone + Magaldrate + SimethiconeN/ASchedule of Domperidone + Magaldrate + SimethiconeN/AStorage Requirements for Domperidone + Magaldrate + SimethiconeN/AEffects of Missed Dosage of Domperidone + Magaldrate + SimethiconeN/AEffects of Overdose of Domperidone + Magaldrate + SimethiconeN/A
DomperidoneAbout DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
Special Precautions while taking Domperidone1.Hepatic impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents.
MagaldrateAbout MagaldrateChemical complex of aluminum and magnesium hydroxides, Antacid.Mechanism of Action of MagaldrateThis neutralizes the gastric acid and increases the gastric pH. This reduces the direct acid irritant effect. It also enhances mucosal barrier integrity and improves gastroesophageal sphincter tone.Pharmacokinets of MagaldrateAbsorption- Moderately absorbed after oral administration. Distribution- It is distributed through locally. Excretion- Excreted through feces and a small amount through breast milk.Onset of Action for Magaldrate20minutesDuration of Action for Magaldrate20 to 180 minutesHalf Life of MagaldrateN/ASide Effects of Magaldrate1. Constipation
3. Increased urine pH
4. Decreased serum potassium levels
5. Increased serum calcium levels
Contra-indications of Magaldrate1. Hypersensitivity to the drug or any ingredients of it
2. Renal impairment or diseases
Special Precautions while taking Magaldrate1.Take this medicine between meals and at bedtime.
2.Shake the oral liquid well before each use.
3.Chew the chewable tablet before swallowing.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Magaldrate1. Peptic ulcer
3. Reflux oesophagitis
4. Gastric hyperacidity
Interactions for MagaldrateN/ATypical Dosage for MagaldrateOral-
Suspension: 5 to 10 ml between meals and at bedtime with water
Schedule of MagaldrateN/AStorage Requirements for MagaldrateStore at room temperature (15 - 25 degree C). Keep out of reach of children.Effects of Missed Dosage of MagaldrateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MagaldrateGive symptomatic and supportive treatment.
SimethiconeAbout SimethiconeOral anti-foaming agent, Silicones, Antiflatulent.Mechanism of Action of SimethiconeThis anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.Pharmacokinets of SimethiconeExcretion- Excreted through feces.Onset of Action for SimethiconeN/ADuration of Action for SimethiconeN/AHalf Life of SimethiconeN/ASide Effects of Simethicone1. Bloating
Contra-indications of Simethicone1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Simethicone1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for SimethiconeN/ATypical Dosage for SimethiconeOral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of SimethiconeN/AStorage Requirements for SimethiconeStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of SimethiconeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SimethiconeGive symptomatic and supportive treatment.
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