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- Pharmacology For Sodium Alginate + Sodium Bicarbonate
Sodium Alginate + Sodium Bicarbonate Pharmacology
Sodium Alginate + Sodium BicarbonateAbout Sodium Alginate + Sodium BicarbonateN/AMechanism of Action of Sodium Alginate + Sodium BicarbonateN/APharmacokinets of Sodium Alginate + Sodium BicarbonateN/AOnset of Action for Sodium Alginate + Sodium BicarbonateN/ADuration of Action for Sodium Alginate + Sodium BicarbonateN/AHalf Life of Sodium Alginate + Sodium BicarbonateN/ASide Effects of Sodium Alginate + Sodium BicarbonateN/AContra-indications of Sodium Alginate + Sodium BicarbonateN/ASpecial Precautions while taking Sodium Alginate + Sodium BicarbonateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Sodium Alginate + Sodium BicarbonateN/AInteractions for Sodium Alginate + Sodium BicarbonateN/ATypical Dosage for Sodium Alginate + Sodium BicarbonateN/ASchedule of Sodium Alginate + Sodium BicarbonateN/AStorage Requirements for Sodium Alginate + Sodium BicarbonateN/AEffects of Missed Dosage of Sodium Alginate + Sodium BicarbonateN/AEffects of Overdose of Sodium Alginate + Sodium BicarbonateN/A
Sodium AlginateAbout Sodium AlginateA hydrophilic colloidal polysaccharide, Added to an antacid as protective agent.Mechanism of Action of Sodium AlginateSodium alginate is the sodium salt of alginic acid.Alginic acid powder swells when wetted with water. This may prevent reflux of acid into the esophagus by keeping the gastric contents in place and reduce the likelihood of reflux irritating the lining of the esophagus. The sodium calcium alginate fibres in haemostatic wound dressings absorbed by body fluids, as the calcium in the fiber is exchanged for sodium from the body fluids mixed salts of sodium and calcium alginate, and processed into non-woven fabric that is used in wound dressings. It binds with heavy metals and radioactive substances to its own molecules. It cannot be broken down by bile or saliva to be absorbed and secreted from the body together with heavy metals and radioactive substances.Pharmacokinets of Sodium AlginateWhen ingested, Sodium alginate releases alginic acid and almost all of the alginic acid remains undigested and is excreted either unchanged or as an alginate.Onset of Action for Sodium AlginateN/ADuration of Action for Sodium Alginate30 to 60 minutesHalf Life of Sodium AlginateN/ASide Effects of Sodium Alginate1. Abdominal distension
3. Chalky taste in your mouth
Contra-indications of Sodium Alginate1. Hypersensitivity to the drug
2. Heart failure.
3. Renal failure.
Special Precautions while taking Sodium Alginate1.Allergies to medicines, foods, or other substances
9.Congestive heart failure
12.Rectal bleeding of unknown cause
13.Recently had stomach bleeding
14.Patient on low salt dietPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Sodium Alginate1. Heartburn (including heartburn of pregnancy)
3. Reflux oesophagitis
4. Hiatus hernia.
5. Protect inflamed areas near the entrance to the stomach (Sodium alginate)
Interactions for Sodium AlginateN/ATypical Dosage for Sodium AlginateTake the drug as directed by the physician.Schedule of Sodium AlginateN/AStorage Requirements for Sodium AlginateStore below 25?C in a tightly closed container.Effects of Missed Dosage of Sodium AlginateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Sodium AlginateGive symptomatic and supportive treatment.
Sodium BicarbonateAbout Sodium BicarbonateSodium compound, Systemic Antacid ,alkalinizer.Mechanism of Action of Sodium BicarbonateSodium bicarbonate in water dissociates to sodium (Na+) and bicarbonate (HCO3 -) ions. Sodium (Na+) is the principal cation of the extracellular fluid and it maintains fluid and electrolyte disturbances. Bicarbonate (HC03 -) is a normal constituent of body fluids. Plasma concentration is regulated by the kidney through acidification of the urine when there is a deficit or by alkalinization of the urine when there is an excess. Bicarbonate anion is considered ``labile`` since at a proper concentration of hydrogen ion (H+) it may be converted to carbonic acid (H2CO3) and hence to its volatile form, carbon dioxide (CO2) which is excreted by the lung.
Sodium bicarbonate can neutralize or reduce acids in the blood, or urine. It is also used in emergency medical situations (heart attacks, serious kidney or lung problems) to correct the normal acid-base balance in the blood or as an aid in treating overdoses with certain types of medications.Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.
Sodium bicarbonate is used in a serious condition called metabolic acidosis. This is when the acidity of blood and tissues is abnormally high. It arises when the body`s normal acid balancing mechanisms fail, for example, in cardiac arrest or severe kidney disease. Sodium bicarbonate neutralises the excess acid.
Pharmacokinets of Sodium BicarbonateAbsorption: Sodium bicarbonate is well absorbed and reabsorbed after parenteral administration in ionized forms.
Excretion: Less than 1% is excreted in urine.Onset of Action for Sodium BicarbonateN/ADuration of Action for Sodium BicarbonateN/AHalf Life of Sodium BicarbonateN/ASide Effects of Sodium Bicarbonate1. Gastric disturbances
6. Pain at the site of injection
7. Venous irritation
8. Chemical cellulites
10. Tissue necrosis at the site of infiltration confusion
11. Swelling of the feet and legs
Contra-indications of Sodium Bicarbonate1. Metabolic alkalosis
2. Respiratory alkalosis
3. Patients losing chlorides by vomiting or from continuous suction
4. Patient on diuretics which produces hypochloremic alkalosis
5. Hypocalcaemia in which alkalosis may produce tetany
8. Heart failure
Special Precautions while taking Sodium Bicarbonate1. Renal impairment
2. Edema with sodium retention
4. Cushing`s syndrome
6. Heart problems
8. Low blood levels of calcium or potassium
9. Ulcers in the esophagus
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Sodium Bicarbonate1. Metabolic acidosis
2. Severe diarrhoea
3. Urine alkalinization
Interactions for Sodium BicarbonateThe renal clearance of the following agents may be :
a) increased - Chlorpropamide, lithium, methotrexate, salicylate, tetracycline.
b) decreased - Anorexients, quinidine, sympathomimetics.
Incompatibility : Avoid adding sodium bicarbonate to parenteral solution containing calcium, precipitation may result. Norepinephrine and dobutamine are incompatible.Typical Dosage for Sodium BicarbonateAdult:
In cardiac arrest: 200 - 300 mEq of a 7.5 - 8.4 % solution as rapidly as possible and in emergency inject 300 - 500 ml of 5% solution.
Metabolic acidosis: 90 - 180 mEq/L as IV during first hour and then adjust the dose depending on patients response.
Urinary alkalization: 0.325 - 2 g in 3- 4 times daily for patients above 60 years maximum dose is 8g and in patients below 60 years is 17 g.
Children: 1 - 10 mEq/kg / day
Children up to two years of age: 1 mEq / kg IV bolus of 4.2% solution and dose may be repeated every 10 minutes. Maximum daily dose: 8 mEq/ kgSchedule of Sodium BicarbonateN/AStorage Requirements for Sodium BicarbonateStore at room temperature between 15 and 30 degrees C Do not freeze. Keep out of the reach of childrenEffects of Missed Dosage of Sodium BicarbonateDo not applyEffects of Overdose of Sodium BicarbonateGive supportive measures and symptomatic treatment. Correct the electrolyte balance. Ammonium chloride can be given in severe alkalosis.
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