Peripheral action: It acts by inhibition of Prostaglandin (PGs) synthesis by blocking the activity of the precursor enzyme cyclo-oxygenase.
Anti-inflammatory action: It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Aspirin inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits other inflammatory mediators.
Antipyretic action: Aspirin lowers fever by affecting thermoregulation in the CNS and by inhibiting the action of prostaglandins peripherally. Aspirin inhibits the production of prostaglandin E1 which is the powerful pyretic agent.
Anticoagulant action: Aspirin inhibits the synthesis of Thromboxane A2 and Prostacyclin (PGI2). This leads to inhibition of platelet aggregation.
3.Bleeding disorders- Haemophilia, von Willebrand`s disease
4.Chicken pox and flu like syndrome in children
3.Cardiovascular diseases- hypertension
6.Pre existing asthma
7.Patient on anticoagulant therapy
3rd trimester: Contraindicated
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints,
6.For the relief of fever, pain and inflammation in dental, minor surgery and orthopedic
9. Juvenile arthritis
Activated charcoal: Decreases absorption of aspirin.
Antacids Urinary alkalizers and Cortiosteroids: Decrease efficacy of aspirin.
Drugs affected by aspirin:
Alcohol: Risk of G.I. ulceration increases; may also prolong bleeding time.
ACE inhibitors: Antihypertensive action decreased.
Oral Anticoagulants : May potentiate effect.
Methotrexate: Effect potentiated.
Tetracycline: Efficacy decreased.
Tricyclic Antidepressants - Effect potentiated.
Nitroglycerin: May result in unexpected hypotension.
Beta-adrenergic Blockers - Antihypertensive effect blunted.
NSAIDs: May decrease serum concentration.
Sulfonylureas and Exogenous Insulin: In high doses may potentiate these drugs.
Valproic Acid: Potentiates effect.
Spironolactone: May inhibit diuretic effect.
Probenecid & Sulfinpyrazone : Antagonise uricosuric effect (In doses > 3gm/day - uricosuric effect)
Thyroid Function Tests: Increase in PBI
Serum Uric Acid Levels: Increased by levels less than 10 mg/dl and decreased by levels> 10 mg/dl.
Urine Glucose: False negative by glucose oxidase method. False positive results by reduction method.
Urinary Ketones: Produce reddish colour.
Analgesic, antipyretic: 325 - 650mg 3 -4 times daily.
Anti-inflammatory, Arthritis: 3 g / day in divided doses increases the dose if needed.
Maintenance: 3.6 - 5.4 g / day in divided doses.
Rheumatic fever: 4.9 - 7.8 g / day in 3 - 4 divided doses for 1- 2 weeks
For prophylaxis of venous thromboembolism after total hip replacement: 650 mg twice a day started 1 day before surgery and continued for 2 weeks.
For other platelet aggregation inhibitory uses: 325 to 1300 mg daily according to individual needs.
For migraine: 300 - 600 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Arthritis: 60 - 130 mg / kg body weight /day in divided doses
Anti-inflammatory: 60 - 125 mg / kg daily in 4 - 6 hours
Analgesic and Antipyretic: Adults: 1 to 2 tablets (325 to 650 mg) orally every 4 hours.
Children under 12: 10 to 15 mg/kg every 6 hours, not to exceed total daily dose of 2.4 g.
Home Delivery for Aspirin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including aspirin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for aspirin and other medicines and health products. Home delivery services for aspirin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take aspirin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for aspirin before they complete the sale. You can get this information while placing the order for aspirin with the pharmacy.
Aspirin is a generic medicine name and there are several brands available for it. Some of the brands for aspirin might be better known than aspirin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aspirin in stock, you can ask for one of the branded alternatives for aspirin.