Ibuprofen Pharmacology


About Ibuprofen
NSAID, a propionic acid derivative, Analgesic and anti-inflammatory.
Mechanism of Action of Ibuprofen
Ibuprofen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Ibuprofen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits platelet aggregation and prolongs bleeding time.
Pharmacokinets of Ibuprofen
Absorption: Ibuprofen is rapidly absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Ibuprofen and its metabolites are excreted mainly in the urine and some amount in bile.
Onset of Action for Ibuprofen
? hours
Duration of Action for Ibuprofen
4-6 hours.
Half Life of Ibuprofen
2 hours
Side Effects of Ibuprofen
4.Gastrointestinal bleeding
5.Abdominal distress
7.Peptic ulcer
11.Blurring of vision

Contra-indications of Ibuprofen
1.Hypersensitivity to Ibuprofen and other NSAIDs
2.Peptic ulcer
Special Precautions while taking Ibuprofen
1.Hepatic impairment
2.Renal impairment
4.Gastrointestinal diseases
5.Pre existing asthma
6.Bleeding disorders
9.Heart failure
10.Myocardial infarction
Pregnancy Related Information
Use with caution
PREGNANCY in third trimester: contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
CHILDREN below 6 months: contraindicated
Indications for Ibuprofen
1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
6.For the relief of fever, pain and inflammation in dental, minor surgery and orthopedic
8.Juvenile arthritis
10.Patent ductus arteriosus(IV)
Interactions for Ibuprofen
Typical Dosage for Ibuprofen
Adult: 1.2 g / day in3 divided doses
Arthritis, gout and dental pain: 300 - 800 mg 3 times daily dose can be increased if needed.
Maximum dose: 3200 mg / day
Pain, Dysmenorrhoea: 1600 - 2400 mg / day in 4 - 6 divided doses
Fever: 600 mg / day in 3 divided doses.
Maximum dose: 1200 mg / day
For migraine: 400 -800 mg 3 times daily
Children: 15- 20 mg / kg body weight / day in 3 - 4 divided doses
Maximum dose: 40 mg / kg body weight / day

Schedule of Ibuprofen
Storage Requirements for Ibuprofen
Store Ibuprofen at 15-30 degree C in a tightly closed light resistant container.
Effects of Missed Dosage of Ibuprofen
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ibuprofen
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Excretion of the drug can be enhanced by administration of alkaline diuretics.

Home Delivery for Ibuprofen in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ibuprofen.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ibuprofen and other medicines and health products. Home delivery services for ibuprofen may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ibuprofen only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ibuprofen before they complete the sale. You can get this information while placing the order for ibuprofen with the pharmacy.

Ibuprofen is a generic medicine name and there are several brands available for it. Some of the brands for ibuprofen might be better known than ibuprofen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ibuprofen in stock, you can ask for one of the branded alternatives for ibuprofen.