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- Pharmacology For Mosapride
MosaprideAbout MosaprideA selective 5HT4 agonist, A gastroprokinetic agent.Mechanism of Action of MosaprideMosapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Mosapride produces 5HT3 receptor antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.Pharmacokinets of MosaprideAbsorption:It is absorbed after oral administration.Excretion: It is excreted mainly urine and faeces.
Onset of Action for MosaprideN/ADuration of Action for MosaprideN/AHalf Life of Mosapride2 - 3 hoursSide Effects of Mosapride1.Diarrhoea
Contra-indications of Mosapride1.Hypersensitivity to MosaprideSpecial Precautions while taking Mosapride1.Hepatic impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
Indications for Mosapride1.Gastroesophageal reflux diseases
4.Disorders associated with decreased gastric motility
Interactions for MosaprideMosapride`s major degradation system is the cytochrome P450 (3A4) system. However, electrophysiological studies show that coadministration of drugs that inhibit the CYP 3A4 enzymes (erythromycin, ketoconazole, fluconazole, etc.) have no effect on mosapride indicating that a satisfactory safety margin exists in relation to rhythm abnormalities, unlike that which occurs with cisapride. Typical Dosage for MosaprideAdult:
Oral:2.5 - 10 mg every 6 - 8 hours in a day with meals
Schedule of MosaprideN/AStorage Requirements for MosaprideStore at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of MosaprideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MosaprideGive supportive measures and symptomatic treatment.
Home Delivery for Mosapride in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mosapride.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mosapride and other medicines and health products. Home delivery services for mosapride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take mosapride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mosapride before they complete the sale. You can get this information while placing the order for mosapride with the pharmacy.
Mosapride is a generic medicine name and there are several brands available for it. Some of the brands for mosapride might be better known than mosapride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mosapride in stock, you can ask for one of the branded alternatives for mosapride.