Mosapride Pharmacology


About Mosapride
A selective 5HT4 agonist, A gastroprokinetic agent.
Mechanism of Action of Mosapride
Mosapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Mosapride produces 5HT3 receptor antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.
Pharmacokinets of Mosapride
Absorption:It is absorbed after oral administration.Excretion: It is excreted mainly urine and faeces.

Onset of Action for Mosapride
Duration of Action for Mosapride
Half Life of Mosapride
2 - 3 hours
Side Effects of Mosapride
2.Abdominal cramps
4.Dry mouth
Contra-indications of Mosapride
1.Hypersensitivity to Mosapride
Special Precautions while taking Mosapride
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
NEONATES: contraindicated
Indications for Mosapride
1.Gastroesophageal reflux diseases
2.Functional dyspepsia
3.Diabetic gastropathy
4.Disorders associated with decreased gastric motility
Interactions for Mosapride
Mosapride`s major degradation system is the cytochrome P450 (3A4) system. However, electrophysiological studies show that coadministration of drugs that inhibit the CYP 3A4 enzymes (erythromycin, ketoconazole, fluconazole, etc.) have no effect on mosapride indicating that a satisfactory safety margin exists in relation to rhythm abnormalities, unlike that which occurs with cisapride.
Typical Dosage for Mosapride
Oral:2.5 - 10 mg every 6 - 8 hours in a day with meals
Children:not recommended
Schedule of Mosapride
Storage Requirements for Mosapride
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Mosapride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Mosapride
Give supportive measures and symptomatic treatment.

Home Delivery for Mosapride in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mosapride.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mosapride and other medicines and health products. Home delivery services for mosapride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mosapride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mosapride before they complete the sale. You can get this information while placing the order for mosapride with the pharmacy.

Mosapride is a generic medicine name and there are several brands available for it. Some of the brands for mosapride might be better known than mosapride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mosapride in stock, you can ask for one of the branded alternatives for mosapride.